Patents by Inventor Martin Gawlitzek

Martin Gawlitzek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CELL CULTURE COMPOSITIONS AND METHODS FOR POLYPEPTIDE PRODUCTION
    Publication number: 20240093143
    Abstract: Cell culture media, such as chemically defined cell culture media, are provided, as are methods of using the media for cell growth (i.e., cell culture) and polypeptide (e.g., antibody) production. Compositions comprising polypeptides produced by the methods are also provided.
    Type: Application
    Filed: October 30, 2023
    Publication date: March 21, 2024
    Applicant: GENENTECH, INC.
    Inventors: Natarajan Vijayasankaran, Steven J. Meier, Melissa S. Mun, Sharat Varma, Yi Yang, Boyan Zhang, Silvana R. Arevalo, Martin Gawlitzek, Veronica Carvalhal
  • CELL CULTURE COMPOSITIONS AND METHODS FOR POLYPEPTIDE PRODUCTION
    Publication number: 20240052392
    Abstract: Cell culture media, such as chemically defined cell culture media, are provided, as are methods of using the media for cell growth (i.e., cell culture) and polypeptide (e.g., antibody) production. Compositions comprising polypeptides produced by the methods are also provided.
    Type: Application
    Filed: October 20, 2023
    Publication date: February 15, 2024
    Applicant: GENENTECH, INC.
    Inventors: Steven J. Meier, Melissa S. Mun, Natarajan Vijayasankaran, Sharat Varma, Yi Yang, Boyan Zhang, Silvana R. Arevalo, Martin Gawlitzek, Veronica Carvalhal
  • PRODUCTION OF PROTEINS IN GLUTAMINE-FREE CELL CULTURE MEDIA
    Publication number: 20210324098
    Abstract: The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture.
    Type: Application
    Filed: March 30, 2021
    Publication date: October 21, 2021
    Applicant: Genentech, Inc.
    Inventors: Martin GAWLITZEK, Shun LUO, Christina Teresa BEVILACQUA
  • Production of proteins in glutamine-free cell culture media
    Patent number: 10982003
    Abstract: The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: April 20, 2021
    Assignee: Genentech, Inc.
    Inventors: Martin Gawlitzek, Shun Luo, Christina Teresa Bevilacqua
  • PRODUCTION OF PROTEINS IN GLUTAMINE-FREE CELL CULTURE MEDIA
    Publication number: 20190263921
    Abstract: The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture.
    Type: Application
    Filed: May 15, 2019
    Publication date: August 29, 2019
    Applicant: Genentech, Inc.
    Inventors: Martin GAWLITZEK, Shun LUO, Christina Teresa BEVILACQUA
  • METHODS OF DECREASING TRISULFIDE BONDS DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES
    Publication number: 20190169667
    Abstract: Provided herein are cell culture media and methods culturing host cells expressing polypeptides to reduce the level of trisulfide bonds in polypeptides produced by the host cells.
    Type: Application
    Filed: November 9, 2018
    Publication date: June 6, 2019
    Applicant: GENENTECH, INC.
    Inventors: Martin GAWLITZEK, Sven MARKERT, Oliver POPP, Masaru Ken SHIRATORI, Thomas TROEBS, Jessica WUU
  • PRODUCTION OF PROTEINS IN GLUTAMINE-FREE CELL CULTURE MEDIA
    Publication number: 20190023800
    Abstract: The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture.
    Type: Application
    Filed: September 21, 2018
    Publication date: January 24, 2019
    Applicant: Genentech, Inc.
    Inventors: Martin GAWLITZEK, Shun LUO, Christina Teresa BEVILACQUA
  • PRODUCTION OF PROTEINS IN GLUTAMINE-FREE CELL CULTURE MEDIA
    Publication number: 20180148510
    Abstract: The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture.
    Type: Application
    Filed: January 26, 2018
    Publication date: May 31, 2018
    Applicant: Genentech, Inc.
    Inventors: Martin GAWLITZEK, Shun LUO, Christina Teresa BEVILACQUA
  • PRODUCTION OF PROTEINS IN GLUTAMINE-FREE CELL CULTURE MEDIA
    Publication number: 20170283505
    Abstract: The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture.
    Type: Application
    Filed: June 14, 2017
    Publication date: October 5, 2017
    Applicant: Genentech, Inc.
    Inventors: Martin GAWLITZEK, Shun LUO, Christina Teresa BEVILACQUA
  • Production of proteins in glutamine-free cell culture media
    Patent number: 9714293
    Abstract: The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: July 25, 2017
    Assignee: GENENTECH, INC.
    Inventors: Martin Gawlitzek, Shun Luo, Christina Teresa Bevilacqua
  • PRODUCTION OF PROTEINS IN GLUTAMINE-FREE CELL CULTURE MEDIA
    Publication number: 20160024217
    Abstract: The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture.
    Type: Application
    Filed: March 26, 2015
    Publication date: January 28, 2016
    Applicant: GENENTECH, INC.
    Inventors: Martin GAWLITZEK, Shun LUO, Christina Teresa PETRAGLIA
  • CELL CULTURE COMPOSITIONS AND METHODS FOR POLYPEPTIDE PRODUCTION
    Publication number: 20150267237
    Abstract: Cell culture media, such as chemically defined cell culture media, are provided, as are methods of using the media for cell growth (i.e., cell culture) and polypeptide (e.g., antibody) production. Compositions comprising polypeptides produced by the methods are also provided.
    Type: Application
    Filed: April 24, 2013
    Publication date: September 24, 2015
    Inventors: Steven J. Meier, Melissa S. Mun, Natarajan Vijayasankaran, Sharat Varma, Yi Yang, Boyan Zhang, Silvana R. Arevalo, Martin Gawlitzek, Veronica Carvalhal
  • PRODUCTION OF PROTEINS IN GLUTAMINE-FREE CELL CULTURE MEDIA
    Publication number: 20140024078
    Abstract: The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture.
    Type: Application
    Filed: July 18, 2013
    Publication date: January 23, 2014
    Applicant: GENENTECH, INC.
    Inventors: Martin Gawlitzek, Shun Luo, Christina Teresa Petraglia
  • CELL CULTURE COMPOSITIONS AND METHODS FOR POLYPEPTIDE PRODUCTION
    Publication number: 20130281355
    Abstract: Cell culture media, such as chemically defined cell culture media, are provided, as are methods of using the media for cell growth (i.e., cell culture) and polypeptide (e.g., antibody) production. Compositions comprising polypeptides produced by the methods are also provided.
    Type: Application
    Filed: March 15, 2013
    Publication date: October 24, 2013
    Inventors: Natarajan VIJAYASANKARAN, Steven J. MEIER, Melissa S. MUN, Sharat VARMA, Yi YANG, Boyan ZHANG, Silvana R. AREVALO, Martin GAWLITZEK, Veronica CARVALHAL
  • Production of proteins in glutamine-free cell culture media
    Patent number: 8512983
    Abstract: The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: August 20, 2013
    Inventors: Martin Gawlitzek, Shun Luo, Christina Teresa Petraglia
  • PRODUCTION OF PROTEINS IN GLUTAMINE-FREE CELL CULTURE MEDIA
    Publication number: 20110091936
    Abstract: The present invention relates generally to glutamine-free cell culture media supplemented with arginine. The invention further concerns the production of recombinant proteins, such as antibodies, in arginine-supplemented glutamine-free mammalian cell culture.
    Type: Application
    Filed: August 6, 2010
    Publication date: April 21, 2011
    Inventors: Martin GAWLITZEK, Shun Luo, Christina Teresa Petraglia
  • Cell culture process
    Patent number: 6610516
    Abstract: A glycoprotein is produced by a process comprising culturing mammalian host cells expressing nucleic acid encoding a glycoprotein in the presence of (a) a factor that modifies growth state in a cell culture, (b) a divalent metal cation that can adopt and prefers an octahedral coordination geometry, and/or (c) a plasma component. In this process, the occupancy of an N-linked glycosylation site occupied only in a fraction of a glycoprotein is enhanced. Such culturing is preferably carried out at a temperature of between about 30° C. and 35° C. and/or in the presence of up to about 2 mM of a butyrate salt and/or in the presence of a cell-cycle inhibitor.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: August 26, 2003
    Assignee: Genentech, Inc.
    Inventors: Dana C. Andersen, Tiffany M. Bridges, Martin Gawlitzek, Cynthia A. Hoy
  • Cell culture process
    Patent number: 6506598
    Abstract: A glycoprotein is produced by a process comprising culturing mammalian host cells expressing nucleic acid encoding said glycoprotein in the presence of (a) a factor that modifies growth state in a cell culture, (b) a divalent metal cation that can adopt and prefers an octahedral coordination geometry, and/or (c) a plasma component. In this process, the occupancy of an N-linked glycosylation site occupied only in a fraction of a glycoprotein is enhanced. Such culturing is preferably carried out at a temperature of between about 30° C. and 35° C. and/or in the presence of up to about 2 mM of a butyrate salt and/or in the presence of a cell-cycle inhibitor.
    Type: Grant
    Filed: April 21, 2000
    Date of Patent: January 14, 2003
    Assignee: Genentech, Inc.
    Inventors: Dana C. Andersen, Tiffany M. Bridges, Martin Gawlitzek, Cynthia A. Hoy