Patents by Inventor Martin Geiser

Martin Geiser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • X-Ray Structure of Human Fpps and Use For Selecting Fpps Binding Compounds
    Publication number: 20080139449
    Abstract: The present invention relates to crystalline human farnesyl diphosphate synthase (FPPS), to the three-dimensional structure of free FPPS as well as the three-dimensional structures of FPPS in complex with substrates such as IPP (isopentenyl diphosphate) and/or with inhibitors such as Zometa® or Aredia®. Further, methods for preparing crystals of human FPPS are described. According to the invention the crystals can be used to determine the structures of FPPS homologs mutants, complexes with ligands, FPPS crystal forms and similar molecules of unknown structure. The invention further relates to the use of FPPS crystals to select new FPPS ligands, e.g. by X-ray screening and to design and/or identify inhibitors against FPPS. Furthermore, the invention relates to NMR methods for selecting and/or identifying new low molecular weight binders to FPPS, which represent new therapeutic agents.
    Type: Application
    Filed: January 2, 2006
    Publication date: June 12, 2008
    Inventors: Wolfgang Jahnke, Jean-Michel Rondeau, Martin Geiser, Paul Ramage, Andre Strauss
  • Atomic structure of the catalytic domain for use in designing and identifying inhibitors of zap-70 kinase
    Publication number: 20070026512
    Abstract: The present invention relates to the three dimensional structure of ZAP-70 protein tyrosine kinase and describes methods of making a crystal of ZAP-70 and purification of the catalytic domain of ZAP-70 for use in crystallization. The invention also relates to the use of the three dimensional structure of the catalytic domain of ZAP-70 for identifying and designing ligands which inhibit the biological function of ZAP-70.
    Type: Application
    Filed: September 25, 2003
    Publication date: February 1, 2007
    Inventor: Martin Geiser
  • Antibodies directed to the binding proteins of Bacillus thuringiensis and their use
    Patent number: 5804393
    Abstract: The present invention relates to an antibody which reacts specifically with the binding proteins for Bacillus thuringiensis .delta.-endotoxins and their derivatives. The invention further relates to an anti-idiotype antibody which reacts specifically with the binding proteins for Bacillus thuringiensis .delta.-endotoxins and their derivatives. The invention also provides a test kit which contains a novel antibody. The invention further relates to a method of isolating a novel B. thuringiensis .delta.-endotoxin, to said novel B. thuringiensis .delta.-endotoxin, to a method of identifying a novel B. thuringiensis .delta.-endotoxin which recognises a novel binding protein, to the novel B. thuringiensis .delta.-endotoxin, to a method of determining the amount of binding protein present, and to a method of reducing the resistance development potential in pest control.
    Type: Grant
    Filed: September 2, 1997
    Date of Patent: September 8, 1998
    Assignee: Thermo Trilogy Corporation
    Inventors: Martin Geiser, Pascale Oddou Stock, Herbert Hartman
  • Cleaning, disinfecting and drying machines
    Patent number: D683503
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: May 28, 2013
    Assignee: Belimed AG
    Inventors: Thorsten Helm, Daniel Fichte, Roman Rieder, Martin Geiser, Markus Felder, Werner Wirz
  • Cleaning, disinfecting and drying machine
    Patent number: D688839
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: August 27, 2013
    Assignee: Belimed AG
    Inventors: Thorsten Helm, Daniel Fichte, Roman Rieder, Martin Geiser, Markus Felder, Werner Wirz