Abstract: Provided herein are methods of classifying lesions in medical image of subjects in certain embodiments. Related systems and computer program products are also provided.

Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.

Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.

Abstract: Systems and methods provide modern storage networks, such as those utilizing a non-volatile memory express over Fabric (NVMe-oF) system, with connectivity options that meet low-latency and high-throughput demands. In certain embodiments, this is accomplished by enabling network entities to acquire and utilize network information, including discovery information, to dynamically manage routing tables and build routes, e.g., to allow a host to send out frames through desired interfaces to reach target destinations. An automated IP routing update service allows for dynamically creating, reading, updating, and deleting functions of otherwise static IP routing table entries to streamline functions in the storage fabric.

Abstract: Systems and methods provide zero-configuration provisioning for modern storage networks such as those utilizing a non-volatile memory express over Fabric (NVMe-oF) system. In various embodiments, this is accomplished by leveraging discovery information, such as multicast Domain Name System (mDNS) information, to locate subsystems in a network and to explicitly and dynamically specify target destinations without a Centralized Discovery Controller (CDC) client having to modify its routing table.

Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.

Abstract: Provided herein are methods of generating medical images that include the use of a generative adversarial network (GAN) in certain embodiments. Related methods, systems, and computer program products are also provided.

Abstract: The presently disclosed subject matter provides compositions, kits, and methods comprising imaging agents that can detect Programmed Cell Death Ligand 1 (PD-L1). The presently disclosed imaging agents can be used to detect diseases and disorders, such as cancer, infection, and inflammation, in a subject.

Abstract: The present disclosure relates to prostate specific membrane antigen (PSMA) ligands. In particular, the disclosure relates to PSMA ligands having a glutamate-urea-lysine (GUL) moiety and a chelating agent that can comprise a radiometal. The disclosure also relates to the use of these compounds in imaging and in the treatment of prostate cancer.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for machine learning image reconstruction. In some implementations, first input data representing the image of the one or more internal structures generated using a first imaging device is provided as input to a first machine learning model having one or more fully-connected layers. First output data generated by the first machine learning model is obtained and the first output data together with second input data representing a second image of the one or more internal structures generated using a second imaging device is provided to a second machine learning model having one or more convolutional layers. Second output data generated by the second machine learning model is obtained and used to generate rendering data that, when processed by a computing device, causes the computing device to output a reconstructed image.

Abstract: A major hurdle in the treatment of cancer is chemoresistance induced under hypoxia that is characteristic of tumor microenvironment. Triptolide, a potent inhibitor of eukaryotic transcription, possesses potent antitumor activity. However, its clinical potential has been limited by toxicity and water solubility. To address those limitations of triptolide, the present disclosure designed and synthesized glucose-triptolide conjugates (glutriptolides) and demonstrated their antitumor activity in vitro and in vivo. The glutriptolides disclosed herein possess improved stability in human serum, greater selectivity towards cancer over normal cells and increased potency against cancer cells. Importantly, the glutriptolides are more potent against cancer cells under hypoxic conditions in contrast to existing cytotoxic drugs. These glutriptolides also exhibit sustained antitumor activity, prolonging survival in a prostate cancer metastasis animal model.

Abstract: The presently disclosed subject matter provides a kinetically controlled mixing process, referred to herein as “flash nanocomplexation” or “(FNC),” to accelerate the mixing of a polyanion solution, for example, a plasmid DNA solution, with a polycation solution to match the polyelectrolyte complex (PEC) assembly kinetics through turbulent mixing in a microchamber, thus achieving explicit control of the kinetic conditions for nanoparticle assembly as demonstrated by the tunability of nanoparticle size, composition, hydrodynamic size, hydrodynamic density, surface charge, and polyanion payload.

Abstract: Systems and methods provide modern storage networks, such as those utilizing a non-volatile memory express over Fabric (NVMe-oF) system, with connectivity options that meet low-latency and high-throughput demands. In certain embodiments, this is accomplished by enabling network entities to acquire and utilize network information, including discovery information, to dynamically manage routing tables and build routes, e.g., to allow a host to send out frames through desired interfaces to reach target destinations. An automated IP routing update service allows for dynamically creating, reading, updating, and deleting functions of otherwise static IP routing table entries to streamline functions in the storage fabric.

Abstract: Systems and methods provide zero-configuration provisioning for modern storage networks such as those utilizing a non-volatile memory express over Fabric (NVMe-oF) system. In various embodiments, this is accomplished by leveraging discovery information, such as multicast Domain Name System (mDNS) information, to locate subsystems in a network and to explicitly and dynamically specify target destinations without a Centralized Discovery Controller (CDC) client having to modify its routing table.

Abstract: The methods of the present invention exploit unique biochemical pathways present within infectious organisms to develop small molecule metabolic tracers. Labeled substrates created using these inventive methods were created. The labeled substrates can be used to determine whether a subject is infected with an infectious organism by imaging means, and with use of two or more such labeled substrates, methods of differentiating gram negative infection from gram positive infection, and methods of localizing and quantifying infectious disease burden are provided. The methods of the present invention can assist in the clinical decision to begin empiric antibiotic therapy, determine its efficacy, as well as the choice of antibacterial agents.

Abstract: Genetic constructs comprising reporter genes operably linked to cancer specific or cancer selective promoters (such as the progression elevated gene-3 (PEG-3) promoter and astrocyte elevated gene 1 (AEG-1) promoter) are provided, as are methods for their use in cancer imaging, cancer treatment, and combined imaging and treatment protocols, e.g. for imaging and/or treating spontaneous metastasis. Transgenic animals in which a reporter gene is linked to a cancer specific or cancer selective promoter, and which may be further genetically engineered, bred or selected to have a predisposition to develop cancer, are also provided.

Abstract: A pulse width modulation signaling system includes a first control channel that is configured to receive a hardware Boolean command input from a first hardware status monitor, receive a software multi-bit command input from a first software system, and generate a first pulse width modulated signal that is representative of the Boolean command input and the software multi-bit command input. The hardware Boolean command input is a binary value of either a first state or a second state, the software multi-bit command input includes a binary value of either a first state or a second state, and the first pulse width modulated signal defines a duty cycle.

Abstract: A guide tube pitch adjustment apparatus for aligning distal ends of lance guide tubes in registry with tube openings in a heat exchanger tube sheet is disclosed. A guide tube pitch clamp assembly carried within and supported from a housing. The pitch clamp assembly has at least two V-blocks fastened to a threaded rod. One V-block is fastened to a portion of the threaded rod having right hand threads, and another V-block is fastened to another portion of the threaded rod having left hand threads. Each of the V-blocks supports a portion of one of the guide tubes, and a cross bar clamp within the housing is oriented to span across the V-blocks and adjustably hold the portions of the guide tubes in a spaced relationship such that spacing between the distal ends of adjacent guide tubes may be adjusted by rotation of the threaded rod.

Abstract: A guide tube pitch adjustment apparatus for aligning distal ends of lance guide tubes in registry with tube openings in a heat exchanger tube sheet is disclosed. A guide tube pitch clamp assembly carried within and supported from a housing. The pitch clamp assembly has at least two V-blocks fastened to a threaded rod. One V-block is fastened to a portion of the threaded rod having right hand threads, and another V-block is fastened to another portion of the threaded rod having left hand threads. Each of the V-blocks supports a portion of one of the guide tubes, and a cross bar clamp within the housing is oriented to span across the V-blocks and adjustably hold the portions of the guide tubes in a spaced relationship such that spacing between the distal ends of adjacent guide tubes may be adjusted by rotation of the threaded rod.

Abstract: A guide tube pitch adjustment apparatus for aligning distal ends of lance guide tubes in registry with tube openings in a heat exchanger tube sheet is disclosed. A guide tube pitch clamp assembly carried within and supported from a housing. The pitch clamp assembly has at least two V-blocks fastened to a threaded rod. One V-block is fastened to a portion of the threaded rod having right hand threads, and another V-block is fastened to another portion of the threaded rod having left hand threads. Each of the V-blocks supports a portion of one of the guide tubes, and a cross bar clamp within the housing is oriented to span across the V-blocks and adjustably hold the portions of the guide tubes in a spaced relationship such that spacing between the distal ends of adjacent guide tubes may be adjusted by rotation of the threaded rod.