Abstract: The present disclosure relates to antisense oligonucleotides, which target Alpha-synuclein (SNCA) transcript in a cell, leading to reduced expression of SNCA protein. Reduction of SNCA protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder such as a synucleinopathy.

Abstract: A computer-based method for selecting an actionable item displayed in a graphical user interface on a mobile computer system is provided. The method includes detecting a first gesture, ending at a first position, on a lower portion of a touchscreen; in response to detecting the first gesture, activating a single-handed operation mode; determining a sequence of actionable items for a foreground application executing on a processor; detecting a second gesture on the touchscreen, the second gesture beginning at the first position and ending at a second position; in response to detecting the second gesture, highlighting one of the actionable items of the sequence based on the second position; detecting a third gesture on the touchscreen; and, in response to detecting a release at the second position as the third gesture, selecting the highlighted actionable item for processing by the foreground application and de-activating the single-handed operation mode.

Abstract: In a metering unit (10) having at least one outlet (20) for dispensing an aerosol with a defined concentration, with at least one inlet (180) for a carrier gas, at least one inlet for a liquid, preferably for a hydrogen peroxide solution, and a buffer container (30) for the liquid, it is provided that the metering unit (10) has at least one liquid flow controller (90) on the outflow side.

Abstract: A computer-based method for selecting an actionable item displayed in a graphical user interface on a mobile computer system is provided. The method includes detecting a first gesture, ending at a first position, on a lower portion of a touchscreen; in response to detecting the first gesture, activating a single-handed operation mode; determining a sequence of actionable items for a foreground application executing on a processor; detecting a second gesture on the touchscreen, the second gesture beginning at the first position and ending at a second position; in response to detecting the second gesture, highlighting one of the actionable items of the sequence based on the second position; detecting a third gesture on the touchscreen; and, in response to detecting a release at the second position as the third gesture, selecting the highlighted actionable item for processing by the foreground application and de-activating the single-handed operation mode.

Abstract: A method and system for providing quality click pricing is presented. An example system comprises a click monitor configured to monitor clicks originated from a web site of an affiliate, a post click activity monitor to monitor post click indicators of those users that originated any of the monitored clicks, a click value generator, an earnings per click module, and a compensation calculator. The click value generator may be configured to determine a click value for the affiliate, based on post click indicators. The determined click value may be provided to the earnings per click module configured to translate a click value into a per click earnings value for an affiliate. The compensation calculator may be configured to determine compensation of the affiliate based on the click value and a number of clicks originated from the web site of the affiliate during a certain period of time.

Abstract: An apparatus comprising a base defining a recess shaped to accommodate a bottom of a tank, a pair of side walls extending upwardly from the base, and a pair of end walls extending upwardly from the base. Each side wall defines an indentation on the inner surface thereof shaped to conform to an outer surface of the tank when the bottom of the tank in the recess. One of the end walls defines a notch shaped to accommodate a neck of a bottle lying on a side thereof between the side walls. The apparatus may be used to transport one of the tank and the bottle at a time.

Abstract: An apparatus comprising a base defining a recess shaped to accommodate a bottom of a tank, a pair of side walls extending upwardly from the base, and a pair of end walls extending upwardly from the base. Each side wall defines an indentation on the inner surface thereof shaped to conform to an outer surface of the tank when the bottom of the tank in the recess. One of the end walls defines a notch shaped to accommodate a neck of a bottle lying on a side thereof between the side walls. The apparatus may be used to transport one of the tank and the bottle at a time.