Abstract: The present disclosure relates to antisense oligonucleotides, which target Alpha-synuclein (SNCA) transcript in a cell, leading to reduced expression of SNCA protein. Reduction of SNCA protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder such as a synucleinopathy.

Abstract: A method and system for providing quality click pricing is presented. An example system comprises a click monitor configured to monitor clicks originated from a web site of an affiliate, a post click activity monitor to monitor post click indicators of those users that originated any of the monitored clicks, a click value generator, an earnings per click module, and a compensation calculator. The click value generator may be configured to determine a click value for the affiliate, based on post click indicators. The determined click value may be provided to the earnings per click module configured to translate a click value into a per click earnings value for an affiliate. The compensation calculator may be configured to determine compensation of the affiliate based on the click value and a number of clicks originated from the web site of the affiliate during a certain period of time.

Abstract: An apparatus comprising a base defining a recess shaped to accommodate a bottom of a tank, a pair of side walls extending upwardly from the base, and a pair of end walls extending upwardly from the base. Each side wall defines an indentation on the inner surface thereof shaped to conform to an outer surface of the tank when the bottom of the tank in the recess. One of the end walls defines a notch shaped to accommodate a neck of a bottle lying on a side thereof between the side walls. The apparatus may be used to transport one of the tank and the bottle at a time.

Abstract: An apparatus comprising a base defining a recess shaped to accommodate a bottom of a tank, a pair of side walls extending upwardly from the base, and a pair of end walls extending upwardly from the base. Each side wall defines an indentation on the inner surface thereof shaped to conform to an outer surface of the tank when the bottom of the tank in the recess. One of the end walls defines a notch shaped to accommodate a neck of a bottle lying on a side thereof between the side walls. The apparatus may be used to transport one of the tank and the bottle at a time.