Abstract: The present invention relates to novel therapeutic uses of niclosamide for the treatment of cancer. In particular, a combination of niclosamide or one of its derivatives with an alkylating agent is provided for the treatment of solid tumors. Moreover, niclosamide or one of its derivatives can be used for the treatment of solid tumors characterized by underexpression of NFKBIA. Finally, the invention relates to diagnostic methods for determining whether treatment with niclosamide alone or in combination with an alkylating agent is suitable for a cancer patient.

Abstract: The present invention relates to glioblastoma inhibiting compounds, in particular gambogic acid amid and derivatives thereof for the treatment of glioblastoma. Moreover, methods for determining whether a treatment with the compounds of the invention is suitable for a patient are disclosed.

Abstract: The present invention relates to a tumor cell of the peripheral zone of a tumor and methods of providing such a tumor cell. Further provided is a method for identifying a molecular marker diagnostic for an infiltrative cancer, an antibody, which specifically binds to such molecular marker, a method for identifying a therapeutic compound effective against a metastatic/infiltrative cancer disease and the use of a tumor cell according to the invention.

Abstract: The present invention relates to novel therapeutic uses of niclosamide for the treatment of cancer. In particular, a combination of niclosamide or one of its derivatives with an alkylating agent is provided for the treatment of solid tumors. Moreover, niclosamide or one of its derivatives can be used for the treatment of solid tumors characterized by underexpression of NFKBIA. Finally, the invention relates to diagnostic methods for determining whether treatment with niclosamide alone or in combination with an alkylating agent is suitable for a cancer patient.

Abstract: The present invention relates to glioblastoma inhibiting compounds, in particular gambogic acid amid and derivatives thereof for the treatment of glioblastoma. Moreover, methods for determining whether a treatment with the compounds of the invention is suitable for a patient are disclosed.

Abstract: Microglial precursor cells for use in the treatment of malignant neoplasms of the central nervous system. A method of treating malignant neoplasms of the central nervous system comprising administering a pharmaceutically effective amount of microglial precursor cells to a subject in need thereof.

Abstract: The present invention relates to a tumor cell of the peripheral zone of a tumor and methods of providing such a tumor cell. Further provided is a method for identifying a molecular marker diagnostic for an infiltrative cancer, an antibody, which specifically binds to such molecular marker, a method for identifying a therapeutic compound effective against a metastatic/infiltrative cancer disease and the use of a tumor cell according to the invention.

Abstract: An integrated circuit includes at least one input and output circuit including: a signal terminal that provides an external contact; a protective circuit coupled to the signal terminal; an input driver and/or an output driver coupled to the signal terminal via the protective circuit; and an additional circuit including a first input coupled to the signal terminal via the protective circuit, and an output that provides a test value for operation of the input and output circuit.

Abstract: An integrated circuit includes at least one input and output circuit including: a signal terminal that provides an external contact; a protective circuit coupled to the signal terminal; an input driver and/or an output driver coupled to the signal terminal via the protective circuit; and an additional circuit including a first input coupled to the signal terminal via the protective circuit, and an output that provides a test value for operation of the input and output circuit.

Abstract: The invention relates to a driver circuit with a circuit node (10), at least two first transistors (P1, P2), the load sections of which are switched in series and connect the circuit node (10) with a first voltage (U10), at least two second transistors (N1, N2), the load sections of which are switched in series and connect the circuit node (10) with a reference potential, and a control circuit (P3–P6, N3, D1–D4, R1, 16), which is formed in order to regulate at least a first control voltage (Up2) on at least one transistor (P2) of the at least two first transistors (P1, P2) and at least a second control voltage (UN2) on at least one transistor (N2) of the at least two second transistors (N1, N2) dependent on a voltage at the circuit node (10).

Abstract: The invention relates to a driver circuit with