Abstract: Certain embodiments include a computer mouse including a housing having a bottom surface and a trackball disposed in the housing, where the bottom surface of the housing includes a first planar region, a second planar region, and a spine both common to and dividing the first and second planar regions. The first and second planar regions can be on different planes, where, when in operation, the computer mouse is configured to rest on a work surface, when the computer mouse is configured such that the first planar region of the bottom surface is parallel to the work surface, the computer mouse is tilted at a first angle relative to the work surface, and when the computer mouse is configured such that the second planar region of the bottom surface is parallel to the work surface, the computer mouse is tilted at a second angle relative to the work surface.

Abstract: Certain embodiments include a computer mouse including a housing having a bottom surface and a trackball disposed in the housing, where the bottom surface of the housing includes a first planar region, a second planar region, and a spine both common to and dividing the first and second planar regions. The first and second planar regions can be on different planes, where, when in operation, the computer mouse is configured to rest on a work surface, when the computer mouse is configured such that the first planar region of the bottom surface is parallel to the work surface, the computer mouse is tilted at a first angle relative to the work surface, and when the computer mouse is configured such that the second planar region of the bottom surface is parallel to the work surface, the computer mouse is tilted at a second angle relative to the work surface.

Abstract: The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are inserted into distinct sites in a vector. The invention also generally provides for linking or joining through recombination a number of molecules and/or compounds (e.g., chemical compounds, drugs, proteins or peptides, lipids, nucleic acids, carbohydrates, etc.) which may be the same or different.

Abstract: The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are inserted into distinct sites in a vector. The invention also generally provides for linking or joining through recombination a number of molecules and/or compounds (e.g., chemical compounds, drugs, proteins or peptides, lipids, nucleic acids, carbohydrates, etc.) which may be the same or different.

Abstract: The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are inserted into distinct sites in a vector. The invention also generally provides for linking or joining through recombination a number of molecules and/or compounds (e.g., chemical compounds, drugs, proteins or peptides, lipids, nucleic acids, carbohydrates, etc.) which may be the same or different.

Abstract: The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination .sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are inserted into distinct sites in a vector. The invention also generally provides for linking or joining through recombination a .number of molecules and/or compounds (e.g., chemical compounds, drugs, proteins or peptides, lipids, nucleic acids, carbohydrates, etc.) which may be the same or different.

Abstract: An input device for inputting commands to a host computer includes a base. An upper housing defines a plurality of control buttons for inputting commands to the computer. The base and upper housing are movably coupled to each other to enable the mouse to be placed in a collapsed position and a raised position. A release button is configured to actuate and facilitate raising of the mouse from the collapsed position to the raised position, the raised position placing the mouse a suitable state for inputting commands to the computer using the control buttons.

Abstract: A method of generating a double stranded (ds) recombinant nucleic acid molecule covalently linked in both strands by contacting two or more ds nucleotide sequences with a topoisomerase under conditions such that both termini of at least one end of a first ds nucleotide sequence are covalently linked by the topoisomerase to both termini of at least one end of a second ds nucleotide sequence is provided. Also provided is a method for generating a ds recombinant nucleic acid molecule covalently linked in one strand, by contacting two or more ds nucleotide sequences with a type IA topoisomerase under conditions such that one strand, but not both strands, of one or both ends of a first ds nucleotide sequence are covalently linked by the topoisomerase. Compositions for performing such methods, and compositions generated from such methods also are provided, as are kits containing components useful for conveniently practicing the methods.

Abstract: A system and method for controlling friction between a mouse and the surface upon which it is placed. Reduction of friction can be accomplished in several ways, including: making the feet of the mouse from various different materials, creating layers of air between the mouse and the surface, creating beveled edges for the feet of mouse, etc. In one embodiment, the feet of the mouse are made of a piezo-electric layer bonded to another layer made of a different material. Exciting the piezo-electric layer at certain frequencies makes the two layers shrink and expand differently, thus creating oscillations of the feet. In yet another embodiment, portions of the mouse feet are made of different materials with different coefficients of friction. These different portions of the feet can be pressed down onto the surface with varying amounts of pressure, thus altering the friction.

Abstract: The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are inserted into distinct sites in a vector. The invention also generally provides for linking or joining through recombination a number of molecules and/or compounds (e.g., chemical compounds, drugs, proteins or peptides, lipids, nucleic acids, carbohydrates, etc.) which may be the same or different.

Abstract: A control device for use on a working surface includes a bottom housing configured to be placed on the working surface; a top housing coupled with the bottom housing, the top housing including at least one key; an actuator disposed between the bottom housing and the top housing and coupled with the key; a switch disposed between the bottom housing and the top housing, wherein the switch is activated via application of an actuation force to the key; and an adjustment means configured to enable a user to adjust the actuation force required to activate the key.

Abstract: A method of generating a double stranded (ds) recombinant nucleic acid molecule covalently linked in both strands by contacting two or more ds nucleotide sequences with a topoisomerase under conditions such that both termini of at least one end of a first ds nucleotide sequence are covalently linked by the topoisomerase to both termini of at least one end of a second ds nucleotide sequence is provided. Also provided is a method for generating a ds recombinant nucleic acid molecule covalently linked in one strand, by contacting two or more ds nucleotide sequences with a type IA topoisomerase under conditions such that one strand, but not both strands, of one or both ends of a first ds nucleotide sequence are covalently linked by the topoisomerase. Compositions for performing such methods, and compositions generated from such methods also are provided, as are kits containing components useful for conveniently practicing the methods.

Abstract: An input device for inputting commands to a host computer includes a base. An upper housing defines a plurality of control buttons for inputting commands to the computer. The base and upper housing are movably coupled to each other to enable the mouse to be placed in a collapsed position and a raised position. A release button is configured to actuate and facilitate raising of the mouse from the collapsed position to the raised position, the raised position placing the mouse a suitable state for inputting commands to the computer using the control buttons.

Abstract: An input device for inputting commands to a host computer includes a base. An upper housing defines a plurality of control buttons for inputting commands to the computer. The base and upper housing are movably coupled to each other to enable the mouse to be placed in a collapsed position and a raised position. A release button is configured to actuate and facilitate raising of the mouse from the collapsed position to the raised position, the raised position placing the mouse a suitable state for inputting commands to the computer using the control buttons.

Abstract: The present invention provides an input device such as a mouse which has a unique construction with integrated key plates and integrated side grips. In one embodiment, the input device comprises a housing, which includes a bottom case and an upper member disposed above the bottom case. The upper member includes a palm rest configured to support a user's palm and at least one key plate extending continuously from the palm rest to form a hinge between the at least one key plate and the palm rest without a gap. The key plate is movable in bending relative to the palm rest at the hinge to activate a key switch. The left side grip and the right side grip are formed on a single piece top case connected between the upper member and the bottom case. The left side grip and right side grip typically have concave surfaces.

Abstract: A control device for use on a working surface includes a bottom housing configured to be placed on the working surface; a top housing coupled with the bottom housing, the top housing including at least one key; an actuator disposed between the bottom housing and the top housing and coupled with the key; a switch disposed between the bottom housing and the top housing, wherein the switch is activated via application of an actuation force to the key; and an adjustment means configured to enable a user to adjust the actuation force required to activate the key.