Abstract: Provided are compounds of Formula (I): including compounds of Formulas (II), (III) and (IV), wherein X, R1, R2, R3 and n are as defined herein, and pharmaceutically acceptable salts thereof, and methods for their use and production. These compounds can be useful, e.g., in the treatment of disorders responsive to the inhibition of apoptosis signal-regulating kinase 1 (ASK1).

Abstract: Provided are compounds of Formula (I?): or pharmaceutically acceptable salts thereof, wherein the variables in the formula are as defined herein; and methods for their use and production.

Abstract: CRISPNA, a new tool for genome editing and diagnosis. The present invention relates to methods and systems for genome editing and diagnosis, and specifically relates to use of Peptide Nucleic Acids (PNAs) to direct the Cas proteins to their DNA or RNA targets.

Abstract: A circuit enabling precharge, active discharge and battery balancing operations in a single subcircuit is described. According to one or more embodiments, a circuit is provided comprising a first battery comprising a positive terminal coupled to a positive transmission line and a negative terminal coupled to a common node, wherein the positive transmission line comprises a first contactor, a second battery comprising a positive terminal coupled to the common node and a negative terminal coupled to a negative transmission line, wherein the negative transmission line comprises a second contactor, and a subcircuit coupled to the common node, to the positive transmission line, and to the negative transmission line.

Abstract: A slip ring unit for an electric generator is provided. The slip ring unit includes a slip ring attachable to a rotor shaft of the electric generator, a plurality of sliding contacts arranged along a circumference of the slip ring, to provide an electrical connection with the slip ring, at least one temperature sensor for measuring a temperature inside the slip ring unit, a fan for providing a cooling flow in the slip ring unit, and a controller connected to the fan for controlling the cooling flow rate generated by the fan, the controller being connected to the at least one temperature sensor. The at least one temperature sensor is attached to at least a holder for supporting the sliding contacts. The controller is configured in such a way that the cooling flow rate is generated depending on the temperature measured by the at least one temperature sensor.

Abstract: Examples of methods of hot forming structural components are provided. The methods include heating a blank made from an Ultra High Strength Steel with an aluminum coating and forming the heated blank in a multi-step apparatus.

Abstract: Examples of methods of hot forming structural components are provided. The methods include heating a blank made from an Ultra High Strength Steel with an aluminum coating and forming the heated blank in a multi-step apparatus.

Abstract: An energy monitoring system for discharging energy in an energy transfer device of a vehicle, including an isolation monitoring unit, a capacitor unit, a voltage terminal unit and a control unit. The voltage terminal unit is connectable to an energy storage system and transfers energy from the energy storage system to a vehicle subsystem. The isolation monitoring unit includes a first isolation resistor element and switch element. The resistor element is connectable to the voltage terminal unit via the switch element. The capacitor unit is connected to the voltage terminal unit and filters electromagnetic interference by storing energy during energy transfer to the subsystem. The control unit closes the first isolation switch element in case of a disconnection of the energy transfer to form a discharge circuit connecting the isolation monitoring unit and the capacitor unit. The discharge circuit discharges energy stored in the capacitor unit.

Abstract: A rapid cooling system for processing food is disclosed which includes a heat exchanger adapted to receive a first coolant (Coolant-I) at a first temperature and eject Coolant-I at a second temperature, a cooling chamber disposed within the heat exchanger in thermal communication with the heat exchanger, the cooling chamber includes a first inlet adapted to receive a product at an elevated temperature (T1), a second inlet adapted to receive a second coolant (Coolant-II) at a low temperature (T2), and an outlet adapted to release a combination of the product and Coolant-II at a low temperature (Tout) and pressure (Pout), wherein cooling of the product from T1 to Tout does not cause a phase change in the product.

Abstract: Examples of methods of hot forming structural components are provided. The methods include heating a blank made from an Ultra High Strength Steel with an aluminum coating and forming the heated blank in a multi-step apparatus.

Abstract: Press systems for manufacturing hot formed structural components may be provided. The systems comprise a fixed lower body (2), a mobile upper body (3) and a mechanism configured to provide upwards and downwards press progression of the mobile upper body (3) with respect to the fixed lower body (2). The system further comprises a cooling/heating tool (10) configured to cool down and/or heat a previously heated blank having locally different microstructures and mechanical properties which comprises: upper (11) and lower (12) mating dies, and the upper (11) and lower (12) dies comprising two or more die blocks adapted to operate at different temperatures corresponding to zones of the blank having locally different microstructures and mechanical properties, and a press tool (20) configured to draw the blank, wherein the press tool (20) is arranged downstream the cooling/heating tool (10). Moreover, methods for hot forming structural components are also provided.

Abstract: A rapid cooling system for processing food is disclosed which includes a heat exchanger adapted to receive a first coolant (Coolant-I) at a first temperature and eject Coolant-I at a second temperature, a cooling chamber disposed within the heat exchanger in thermal communication with the heat exchanger, the cooling chamber includes a first inlet adapted to receive a product at an elevated temperature (T1), a second inlet adapted to receive a second coolant (Coolant-II) at a low temperature (T2), and an outlet adapted to release a combination of the product and Coolant-II at a low temperature (Tout) and pressure (Pout), wherein cooling of the product from T1 to Tout does not cause a phase change in the product.

Abstract: A resistance welding device, comprising a frame for supporting a tool configured like a clamp with two arms arranged facing one another and having respective welding electrodes, of which a first arm is integral to the clamp and the second arm is assembled with the capacity of being moved with respect to the clamp by means of a first actuator, such that respective movements along a straight trajectory can be imparted to the arms of the clamp for moving their electrodes closer to or away from one another. One of the arms has a hollow head housing the corresponding electrode in a guided manner the tip of which is suitable for receiving the support of a component to be welded on the workpiece, the head and the electrode being able to adopt at least one standby position (A) in which the electrode is inside the mentioned head; and a working position (B), in which the tip of the electrode is arranged in or exceeds the inlet of the head, accordingly placing the component to be welded outside the head.

Abstract: Open filtering equipment for a water treatment station, for open filters with a filter bed such as sand, coal, etc., comprising a plurality of support legs (10), a plurality of frames (20) supported on said support legs (10), each having at least one opening (22), said plurality of frames (20) being suitable to cover the bottom of a filter, and a plurality of filtering assemblies with a flat upper surface, each of them attachable on a frame (20) covering an opening (22) thereof, and each filter assembly comprising a filtering grid (32) for filtering the water from the filter bed by filtering.

Abstract: Press systems for manufacturing hot formed structural components may be provided. The systems comprise a fixed lower body (2), a mobile upper body (3) and a mechanism configured to provide upwards and downwards press progression of the mobile upper body (3) with respect to the fixed lower body (2). The system further comprises a cooling/heating tool (10) configured to cool down and/or heat a previously heated blank having locally different microstructures and mechanical properties which comprises: upper (11) and lower (12) mating dies, and the upper (11) and lower (12) dies comprising two or more die blocks adapted to operate at different temperatures corresponding to zones of the blank having locally different microstructures and mechanical properties, and a press tool (20) configured to draw the blank, wherein the press tool (20) is arranged downstream the cooling/heating tool (10). Moreover, methods for hot forming structural components are also provided.

Abstract: The present invention provides a method for concentrating a protein, in particular a method for concentrating a plasma product, in particular IgG, using glycine in a two-stage ultrafiltration/diafiltration approach.

Abstract: The present document provides details of a nanostructured material defined by an anodized alumina having a nanostructure with transverse pores that pass through and connect longitudinal pores grown on an aluminum substrate. This document also describes the process for producing said nanostructured material and the possible use thereof as a template or mould for obtaining nanostructures formed by nanowires, which are generated in the cavities or pores of the aforementioned nanostructure of the nanomaterial of the invention. Likewise, this document details the use of the nanostructured anodized alumina material as a mould for producing nanostructures.

Abstract: Described are emulsion compositions comprising oil, water and partially hydrolyzed soy beta-conglycinin, as well as materials and methods for their preparation and use. The soy beta-conglycinin can be enzyme-hydrolyzed material, such as trypsinized material. The degree of hydrolysis of the soy beta-conglycinin can be light, for example up to 2.5%. The hydrolyzed soy beta-conglycinin can be effective to form fibril sheets adsorbed to oil droplets at the interface between the droplets and a continuous aqueous phase in an emulsion composition. The soy beta-conglycinin can be hydrolyzed to such an extent that it provides improved oxidative stability to the oil in the emulsion composition while also providing physical stability equal to and/or greater than that obtained using a corresponding nonhydrolyzed soy beta-conglycinin composition.

Abstract: Press systems for manufacturing hot formed structural components are provided. The systems comprise a fixed lower body, a mobile upper body and a mechanism configured to provide upwards and downwards press progression of the mobile upper body with respect to the fixed lower body. The system further includes a cooling tool configured to cool down a previously heated blank. The cooling tool includes upper and lower mating dies, the lower die connected to the lower body with one or more lower biasing elements and/or the upper die connected to the upper body with one or more upper biasing elements. The system further includes a press tool configured to draw the blank, wherein the press tool is arranged downstream from the cooling tool. Moreover, methods for hot forming structural components are also provided.

Abstract: Press systems for manufacturing hot formed structural components are provided. The systems comprise a fixed lower body, a mobile upper body and a mechanism configured to provide upwards and downwards press progression of the mobile upper body with respect to the fixed lower body. The system further includes a cooling tool configured to cool down a previously heated blank. The cooling tool includes upper and lower mating dies, the lower die connected to the lower body with one or more lower biasing elements and/or the upper die connected to the upper body with one or more upper biasing elements. The system further includes a press tool configured to draw the blank, wherein the press tool is arranged downstream from the cooling tool. Moreover, methods for hot forming structural components are also provided.