Patents by Inventor Martin GRAPOW

Martin GRAPOW has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11648103
    Abstract: The invention relates to an artificial vascular graft comprising a primary scaffold structure encompassing an inner space of the artificial vascular graft, said primary scaffold structure having an inner surface facing towards said inner space and an outer surface facing away from said inner space, a coating on said inner surface, wherein a plurality of grooves is comprised in said coating of said inner surface. The primary scaffold structure comprises further a coating on said outer surface. The primary scaffold structure and the coating on said inner surface and on said outer surface are d designed in such a way that cells, in particular progenitor cells, can migrate from the periphery of said artificial vascular graft through said outer surface of said coating, said primary scaffold structure and said inner surface to said inner space, if the artificial vascular graft is used as intended. The invention relates further to a method for providing said graft.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: May 16, 2023
    Assignee: UNIVERSITÄTSSPITAL BASEL
    Inventors: Bernhard Winkler, Martin Grapow, Friedrich Eckstein, Aldo Ferrari, Dimos Poulikakos, Simone Bottan, Maximilian Fischer, Tobias Lendenmann
  • Publication number: 20190159880
    Abstract: The invention relates to an artificial vascular graft comprising a primary scaffold structure encompassing an inner space of the artificial vascular graft, said primary scaffold structure having an inner surface facing towards said inner space and an outer surface facing away from said inner space, a coating on said inner surface, wherein a plurality of grooves is comprised in said coating of said inner surface. The primary scaffold structure comprises further a coating on said outer surface. The primary scaffold structure and the coating on said inner surface and on said outer surface are d designed in such a way that cells, in particular progenitor cells, can migrate from the periphery of said artificial vascular graft through said outer surface of said coating, said primary scaffold structure and said inner surface to said inner space, if the artificial vascular graft is used as intended. The invention relates further to a method for providing said graft.
    Type: Application
    Filed: December 11, 2018
    Publication date: May 30, 2019
    Inventors: Bernhard WINKLER, Martin GRAPOW, Friedrich ECKSTEIN, Aldo FERRARI, Dimos POULIKAKOS, Simone BOTTAN, Maximilian FISCHER, Tobias LENDENMANN
  • Patent number: 10188499
    Abstract: The invention relates to an artificial vascular graft comprising a primary scaffold structure encompassing an inner space of the artificial vascular graft, said primary scaffold structure having an inner surface facing towards said inner space and an outer surface facing away from said inner space, a coating on said inner surface, wherein a plurality of grooves is comprised in said coating of said inner surface. The primary scaffold structure comprises further a coating on said outer surface. The primary scaffold structure and the coating on said inner surface and on said outer surface are d designed in such a way that cells, in particular progenitor cells, can migrate from the periphery of said artificial vascular graft through said outer surface of said coating, said primary scaffold structure and said inner surface to said inner space, if the artificial vascular graft is used as intended. The invention relates further to a method for providing said graft.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: January 29, 2019
    Assignee: UNIVERSITÄTSSPITAL BASEL
    Inventors: Bernhard Winkler, Martin Grapow, Friedrich Eckstein, Aldo Ferrari, Dimos Poulikakos, Simone Bottan, Maximilian Fischer, Tobias Lendenmann
  • Patent number: 10173352
    Abstract: A method for the self-assembled production of a topographically surface structured cellulose element. First, a mold is provided having on one side a first surface which is in a complementary manner topographically structured and which is permeable to oxygen. Next, a liquid growth medium containing cellulose producing bacteria is provided. Then, the mold is placed to form a interface such that the side of the mold with the first surface is in direct contact with the liquid growth medium, and an opposite side is facing air or a specifically provided oxygen containing gas surrounding. This allows bacteria to be produced and deposit cellulose on the first surface and developing on the interface a surface structured surface complementary thereto, until a cellulose layer with a thickness of the element of at least 0.3 mm is formed. Finally; the element is removed from the mold.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: January 8, 2019
    Assignee: ETH ZURICH
    Inventors: Tobias Lendenmann, Maximilian Fischer, Simone Bottan, Aldo Ferrari, Dimos Poulikakos, Bernhard Winkler, Martin Grapow
  • Publication number: 20160228233
    Abstract: The invention relates to an artificial vascular graft comprising a primary scaffold structure encompassing an inner space of the artificial vascular graft, said primary scaffold structure having an inner surface facing towards said inner space and an outer surface facing away from said inner space, a coating on said inner surface, wherein a plurality of grooves is comprised in said coating of said inner surface. The primary scaffold structure comprises further a coating on said outer surface. The primary scaffold structure and the coating on said inner surface and on said outer surface are d designed in such a way that cells, in particular progenitor cells, can migrate from the periphery of said artificial vascular graft through said outer surface of said coating, said primary scaffold structure and said inner surface to said inner space, if the artificial vascular graft is used as intended. The invention relates further to a method for providing said graft.
    Type: Application
    Filed: September 18, 2014
    Publication date: August 11, 2016
    Inventors: Bernhard WINKLER, Martin GRAPOW, Friedrich ECKSTEIN, Aldo FERRARI, Dimos POULIKAKOS, Maximilian FISCHER, Tobias LENDENMANN
  • Publication number: 20160221228
    Abstract: A method for the self-assembled production of a topographically surface structured cellulose element. First, a mold is provided having on one side a first surface which is in a complementary manner topographically structured and which is permeable to oxygen. Next, a liquid growth medium containing cellulose producing bacteria is provided. Then, the mold is placed to form a interface such that the side of the mold with the first surface is in direct contact with the liquid growth medium, and an opposite side is facing air or a specifically provided oxygen containing gas surrounding. This allows bacteria to be produced and deposit cellulose on the first surface and developing on the interface a surface structured surface complementary thereto, until a cellulose layer with a thickness of the element of at least 0.3 mm is formed. Finally; the element is removed from the mold.
    Type: Application
    Filed: September 18, 2014
    Publication date: August 4, 2016
    Applicant: ETH ZÜRICH
    Inventors: Tobias LENDENMANN, Maximilian FISCHER, Simone BOTTAN, Aldo FERRARI, Dimos POULIKAKOS, Bernhard WINKLER, Martin GRAPOW