Abstract: A patch pocket folding apparatus (1) comprises: a template (2), moving means (3) of the template (2), a folding body (4), against which the template (2) pushes a fabric (T), folding blades (5), a folding unit (G) disposed under the folding body (4); the folding unit (G) is composed of a set of strips (6) made of an easily workable rigid material that are fixed under the folding body (4) and define an internal corresponding border having the same profile as the external border of the template (2).

Abstract: The invention relates to a compound which is, 2-[4-[(methylamino)carbonyl]-1H-pyrazol-1-yl]adenosine, which is a selective A2A adenosine receptor agonist in myocardial imaging. The new polymorph of 2-[4-[(methylamino)carbonyl]-1H-pyrazol-1-yl]adenosine (designated as polymorph E) is characterized by an X-ray diffraction pattern of X-RPD showing the following reflections at 2 Theta=5.8°, 12.3°, 15.9°, 17.3°, 20.5°, 22.6°, 23.6°, 27.7°, and 29.2°; and further characterized by a DSC scan showing marked endotherm in the range of 258 to 264° C.; and further characterized by a specific IR spectra.

Abstract: A method of preparation of N-(1-benzo[b]thien-2-ylethyl)-N-hydroxyurea of formula (I) with the use of a reaction of 1-(benzo[b]thien-2-yl)-ethanol of formula (II) with hydroxyurea of formula (III) in organic solvents, organic acids, their mixtures or in mixtures thereof with water, being catalyzed by strongly acidic cation exchangers or various hydrogen sulphates.

Abstract: A new polymorph of 2-[4-[(methylamino)carbonyl]-1H-pyrazol-1-yl]adenosine (designated as polymorph E), characterized by an X-ray diffraction pattern of X-RPD showing the following reflections at 2 Theta=5.8°, 12.3°, 15.9°, 17.3°, 20.5°, 22.6°, 23.6°, 27.7°, and 29.2°, and further characterized by DSC showing marked endotherm in the range of 258 to 264° C.

Abstract: A method for the preparation of 2-(4-methoxycarbonylpyrazol-1-yl)adenosine of formula 1a and 2-(4-ethoxycarbonylpyrazol-1-yl)adenosine of formula 1b by reaction of 2-hydrazinoadenosine of formula III and the sodium salt of 3,3-dimethoxy-2-methoxycarbonylpropen-1-ol of formula Va or the sodium salt of 3,3-diethoxy-2-ethoxycarbonylpropen-1-ol of formula Vb in combination with a solvent and an acidic agent.

Abstract: A method for the preparation of 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine monohydrate of formula I by reaction of 2-(4-methoxycarbonylpyrazol-1-yl) adenosine of formula III with a solution of methylamine in a non-aqueous solvent, optionally in combination with another inert solvent, to produce anhydrous 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yl]adenosine, which is converted to 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1-yljadenosine monohydrate of formula I by addition of water.

Abstract: A method for ascertaining a wheel reference speed of a wheel of a vehicle having a hydrostatic drive which uses a transfer medium, the hydrostatic drive acting at least on the one wheel, and the hydrostatic drive having an oscillating motor which may be swiveled to a pumping mode via which a torque may be applied to the wheel, and a wheel speed sensor for detecting the particular wheel speed being situated near the wheel, and the oscillating motor being appropriately adjusted while the wheel speed sensor ascertains the wheel reference speed in order to allow resistance-free flow of the transfer medium through the oscillating motor. The exemplary embodiments and/or exemplary methods of the present invention further relates to a device having arrangements for carrying out the method, and configured as a hydraulic drive control unit, for example.

Abstract: The invention deals with a preparation method of salts of 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole (tizanidine) of formula I, especially tizanidine hydrochloride, comprising preparation of a salt of tizanidine of formula I and a carboxylic acid as an intermediate, from which, after acidification with hydrogen chloride, tizanidine hydrochloride is obtained in a high yield and purity.

Abstract: A method for preparing 4-[3,5-bis(2-hydroxyphenyl )-[1,2,4]triazol-1-yl]benzoic acid of formula (I) by reaction of 2-(2-hydroxyphenyl)benz[e][1,3]oxazin-4-one of formula (II) with 4-hydrazinobenzoic acid of formula (III) in an organic acid or in a mixture of an organic acid and an organic solvent.

Abstract: The invention deals with a preparation method of salts of 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole (tizanidine) of formula I, especially tizanidine hydrochloride, comprising preparation of a salt of tizanidine of formula I and a carboxylic acid as an intermediate, from which, after acidification with hydrogen chloride, tizanidine hydrochloride is obtained in a high yield and purity.

Abstract: A method for the preparation of salts of 2-[2-(4-dibenzo[b,fj[1,4]thiazepin-11-yl-1 -piperazinyl)ethoxy]ethanol (quetiapine) from the quetiapine base and the respective acid, wherein the salt is precipitated from a mixture of solvents, the mixture being either a mixture of an aromatic hydrocarbon and a ketone or ester, or that of an aromatic hydrocarbon, water and a ketone or ester. The salts of quetiapine are purified by partial crystallization, wherein only a part of the salt of quetiapine is dissolved in a C1 to C6 alcohol used.

Abstract: A method of preparation of N-(1-benzo[b]thien-2-ylethyl)-N-hydroxyurea of formula (I) with the use of a reaction of 1-(benzo[b]thien-2-yl)-ethanol of formula (II) with hydroxyurea of formula (III) in organic solvents, organic acids, their mixtures or in mixtures thereof with water, being catalyzed by strongly acidic cation exchangers or various hydrogen sulphates.

Abstract: A method for preparing 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]benzoic acid of formula (I) by reaction of 2-(2-hydroxyphenyl)benz[e][1,3]oxazin-4-one of formula (II) with 4-hydrazinobenzoic acid of formula (III) in an organic acid or in a mixture of an organic acid and an organic solvent.

Abstract: The invention relates to a hydraulic brake system (1), comprising at least one brake valve (4, 98, 100), which can be manually actuated and by way of which a pressurized medium connection between at least one brake line (53, 54) connected by way of a pressurized medium connection to a wheel brake cylinder (26, 28, 30, 32) and a hydraulic accumulator (6, 8) can be opened. To this end, a wheel valve (16, 18, 20, 22, 102, 176, 178, 180, 182) is disposed between the wheel brake cylinder (26, 28, 30, 32) and the brake valve (4, 98, 100) in the pressurized medium flow path, wherein said wheel valve can be controlled by way of a circuit valve (34, 36, 184, 186, 210, 212) or a control element actuating the brake valve (4, 98, 100), regardless of the manual actuation of the brake valve (4, 98, 100). A plurality of brake circuits (94, 96) can be provided in the brake system, each being associated with a circuit valve 34, 36, 184, 186, 210, 212).

Abstract: A method for ascertaining a wheel reference speed of a wheel of a vehicle having a hydrostatic drive which uses a transfer medium, the hydrostatic drive acting at least on the one wheel, and the hydrostatic drive having an oscillating motor which may be swiveled to a pumping mode via which a torque may be applied to the wheel, and a wheel speed sensor for detecting the particular wheel speed being situated near the wheel, and the oscillating motor being appropriately adjusted while the wheel speed sensor ascertains the wheel reference speed in order to allow resistance-free flow of the transfer medium through the oscillating motor. The exemplary embodiments and/or exemplary methods of the present invention further relates to a device having arrangements for carrying out the method, and configured as a hydraulic drive control unit, for example.

Abstract: A method for the preparation of salts of 2-[2-(4-dibenzo[b,fj[1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol (quetiapine) from the quetiapine base and the respective acid, wherein the salt is precipitated from a mixture of solvents, the mixture being either a mixture of an aromatic hydrocarbon and a ketone or ester, or that of an aromatic hydrocarbon, water and a ketone or ester. The salts of quetiapine are purified by partial crystallization, wherein only a part of the salt of quetiapine is dissolved in a C1 to C6 alcohol used.