Abstract: A process and arrangement automatically generate a floor plan of a building. A set of voxels in the form of polyhedrons is computationally generated and together fill the floor space. The edges of the polyhedron are parallel to the axes of a specified three-dimensional coordinate system. A camera (IR) is moved through the story and generates a sequence of images. The respective position and orientation of the camera (IR) while generating an image are measured. Characteristic key points (S1?, S2?, . . . ) are determined and positioned in the coordinate system. Free voxels (Vx, Vy), i.e. voxels inside a room, are determined. At least one cluster, including a topologically connected set of free voxels, is generated. An enveloping body is placed around each determined cluster. Each enveloping body describes the respective boundaries (W, F) of a room (R.x) of the story.

Abstract: A process and a system automatically determine a floor plan of a spatial area (Et). A mobile sensor arrangement includes a camera and a motion sensor and is moved through the spatial area (Et). The camera generates an image sequence. The motion sensor generates a motion signal. Using the motion signal, a camera trajectory (Tr) is determined that describes the actual motion path of the camera through the spatial area (Et). Those image segments in the images are determined that each show at least one person. Key points are detected in the remaining image segments. Contiguous horizontal surface segments (Zus.1, Zus.2, . . . ) are determined in the images. Using the horizontal surface segments (Zus.1, Zus.2, . . . ), contiguous floor segments (R.1, R.2) are determined. The floor plan is determined using the camera trajectory and the contiguous floor segments.

Abstract: Disclosed herein is an epitope data processing system processes amino acid sequences of a plurality of epitopes determined from a plurality of peptide fragments from a subject. The epitope data processing system identifies a human leukocyte antigen ligand match (HLA-LM) of the epitope by comparing an amino acid sequence of the epitope to an amino acid sequence of at least one unmutated human leukocyte antigen (HLA) ligand, where the HLA-LM binds to at least one HLA allele. The system determines that the epitope is a potentially immunogenic epitope (PIE) based on comparison of % rank of the epitope to the % rank of the HLA-LM for the same HLA allele. The system determines unique epitope-HLA pairs, determines epitope scores, clonality scores, and responder scores for each of the PIES, and ranks the PIEs based on the respective responder scores.

Abstract: Provided herein are methods of modulating immune response, including methods of treating a cancer or an infection using a combination of kinase modulators and immunotherapy that promotes immune response. Also provided herein are methods of treating an autoimmune disease or graft-versus-host disease, and methods of reducing the risk of solid organ transplant rejection using a combination of kinase modulators and immunosuppressive therapy.

Abstract: A noise reduction system (2) and a method for actively compensating background noises in a passenger transport area of a vehicle. Said system includes a control unit (8), at least one microphone (10), at least one sound generator (12) and a position detection unit for detecting a position and/or orientation of the head (16) of a user. The control unit (8) is coupled to the position detection unit on an input side, is configured to receive position data and to determine a position signal from the position data, and to generate an antinoise signal from the background noise signal and the position signal. The sound generator (12) is configured to generate antinoise from the antinoise signal such that, by superimposing the antinoise in a quiet zone (20a, 20b) within the passenger transport area, which antinoise is in phase opposition with the background noise, active reduction of the background noise is achieved. The position detection unit is a 3D camera arrangement (14).

Abstract: A noise reduction system (2) and a method for actively compensating background noises in a passenger transport area of a vehicle. Said system includes a control unit (8), at least one microphone (10), at least one sound generator (12) and a position detection unit for detecting a position and/or orientation of the head (16) of a user. The control unit (8) is coupled to the position detection unit on an input side, is configured to receive position data and to determine a position signal from the position data, and to generate an antinoise signal from the background noise signal and the position signal. The sound generator (12) is configured to generate antinoise from the antinoise signal such that, by superimposing the antinoise in a quiet zone (20a, 20b) within the passenger transport area, which antinoise is in phase opposition with the background noise, active reduction of the background noise is achieved. The position detection unit is a 3D camera arrangement (14).

Abstract: A measuring probe for the invasive measurement of blood parameters such as pH, pO.sub.2 or pCO.sub.2 comprises one or more optical fibers in a tubing. These optical fibers end up in sensors which are surrounded by a sheath. An additional wire is guided both in the tubing and the sheath. At the proximal end of the probe, the wire is connected to locking means closing the sheath at its outer end, whereas, at the distal end thereof, the wire is fastened to the tubing or to a connector. Therefore, this wire ensures perfect strain relieving of the probe.

Abstract: Optical probes for the invasive measurement of blood parameters consist of at last one sensor, each of these sensors having a diffusion zone with a selective membrane. The sensor or the sensors are surrounded by a stabilizing sheath. This sheath is to be fastened on sensor(s) by a glue. A silicone glue provides the feature that gas molecules can diffuse through it; therefore, blood gas sensors such as pO.sub.2 sensors or pCO.sub.2 sensors may be completely embedded in said glue. If a pH sensor is used, it must be placed in the top position of the horizontally lying sheath during manufacturing. The silicone glue then does not cover the diffusion zone of the pH sensor completely. Further, silicone glue provides additional elasticity which improves sensor characteristics.