Abstract: Disclosed herein are base-modified nucleoside-5?-oligophosphates (bm-N5OP) that include a positively charged moiety at least at one position of the base, compositions comprising the same, compositions made from the same, methods of making the same, and methods of using the same. The bm-N5OP disclosed herein are useful, for example, as tagged nucleotides for use in nanoSBS methods and for generating primers and/or templates for use in nanoSBS methods. When incorporated into a polynucleotide, the disclosed bm-N5OPs can neutralize at least a portion of the negative charge of the overall polynucleotide molecule.

Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

Abstract: Disclosed is a brake application mechanism for a disc brake in a utility vehicle, having a pivotable brake lever that is supported on an inner wall of a brake caliper and, indirectly, on a bridge which is movably disposed in the brake caliper and which supports at least one brake pad, wherefor an axially and radially secured antifriction roller is disposed between the brake lever and the bridge. The disclosed brake application mechanism is designed such that the antifriction roller rests on the bridge in such a way as to be prevented from rotating and sliding.

Abstract: The present disclosure relates to a method and a device (10) for cooling an exhaust-gas after-treatment apparatus (12). The device (10) has a coolant circuit (16) with a cooling region (18) for heat transfer with the exhaust-gas aftertreatment apparatus (12) and has at least one backflow preventer (20, 22). The at least one backflow preventer (20, 22) is arranged upstream and/or downstream of the cooling region (18) and is configured and/or oriented such that, in the event of a change in volume of the coolant in the cooling region (18) and in a section of the coolant circuit (16) between the cooling region (18) and the at least one backflow preventer (20, 22), said at least one backflow preventer (20, 22) opens, which takes place below a boiling point of the coolant. A natural circulation of the coolant in the coolant circuit (16) below the boiling point of the coolant can thus preferably be provided.

Abstract: A disc brake for a vehicle, particularly for a commercial vehicle, includes a brake caliper which straddles a brake disc and in which an application device is arranged, a single-piece rotary lever which has an eccentric element, and at least one brake plunger which is designed as a power screw arrangement having a rotational axis and with which, when the rotary lever is actuated, at least one brake pad can be pressed against the brake disc. The rotary lever is arranged in the brake caliper such that it can pivot relative thereto, and is supported directly or by way of one or more elements connected therebetween, on said brake caliper, in at least one support region. The rotary lever, which can pivot relative to the brake plunger, has at least one convexly-formed section on the side thereof that lies opposite the support point on the brake caliper, and this section lies against a matching concave end face in the axial extension of the rotational axis of said power screw arrangement.

Abstract: A disc brake includes a brake caliper that engages over a brake disc, the caliper having a central opening over the brake disc. The disc brake has two brake pads which are located in the brake caliper, can be moved in opposite directions and each of which has a pad backing plate with a friction lining secured thereon. An action-side or application-side brake pad of the two brake pads can be pressed against the brake disc by a brake application device with the aid of at least one brake plunger. The brake also has at least one restoring device, by which the brake caliper can be returned. The restoring device has a spreading device which engages on the brake pads lying opposite one another and which acts with an identical force in opposition to the respective application direction. The spreading device has spring-loaded spreading elements, each engaging on its respective pad backing plate.

Abstract: A disc brake for a vehicle, particularly for a commercial vehicle, includes a brake caliper which straddles a brake disc and in which an application device is arranged, a single-piece rotary lever which has an eccentric element, and at least one brake plunger which is designed as a power screw arrangement having a rotational axis and with which, when the rotary lever is actuated, at least one brake pad can be pressed against the brake disc. The rotary lever is arranged in the brake caliper such that it can pivot relative thereto, and is supported directly or by way of one or more elements connected therebetween, on said brake caliper, in at least one support region. The rotary lever, which can pivot relative to the brake plunger, has at least one convexly-formed section on the side thereof that lies opposite the support point on the brake caliper, and this section lies against a matching concave end face in the axial extension of the rotational axis of said power screw arrangement.

Abstract: A disc brake includes a brake caliper that engages over a brake disc, the caliper having a central opening over the brake disc. The disc brake has two brake pads which are located in the brake caliper, can be moved in opposite directions and each of which has a pad backing plate with a friction lining secured thereon. An action-side or application-side brake pad of the two brake pads can be pressed against the brake disc by a brake application device with the aid of at least one brake plunger. The brake also has at least one restoring device, by which the brake caliper can be returned. The restoring device has a spreading device which engages on the brake pads lying opposite one another and which acts with an identical force in opposition to the respective application direction. The spreading device has spring-loaded spreading elements, each engaging on its respective pad backing plate.