Abstract: The invention relates to the compound of general formula (I) as novel inhibitors of transglutaminases, to methods for producing the inventive compounds, to pharmaceutical compositions containing said inventive compounds and to their use for the prophylaxis and treatment of diseases associated with transglutaminases, in particular transglutaminase 2.

Abstract: The invention relates to the compound of general formula (I) as novel inhibitors of transglutaminases, to methods for producing the inventive compounds, to pharmaceutical compositions containing said inventive compounds and to their use for the prophylaxis and treatment of diseases associated with transglutaminases, in particular transglutaminase 2.

Abstract: Apparatus for the fixed-angle fixation and compression of a fracture site or osteotomy of a bone includes a bone plate having a plurality of holes and bone screws with a threaded head. The bone screws accommodated in the holes are screwed into the bone. At least one of the holes is a combination of two circular holes of different diameter. As screwing of the bone screw into the bone proceeds through a final stage, engagement of the threads on the head with threads in the combination hole effects relative longitudinal displacement between the plate and the bone whereby it is possible to simplify simultaneous fixed angle fixation and compression of the fracture or osteotomy with use of a single screw. Threads on the head of the bone screw engage threads in the hole which is a combination of the two hole to effect relative motions.

Abstract: A knee arthrodesis implant has a femur nail and a tibia nail. A connecting module has two longitudinally separated half shells that when connected form a passage. One end of the connecting module is coupled to a femur nail neck and the other end is coupled to a tibia nail neck. The half shells have a plurality of corresponding recesses extending perpendicularly to the passage. Each recess receives a tensioning screw, and tightening the tensioning screws couples the femur and tibia nail necks to the connecting module by holding the femur and tibia nail necks within the passage by frictional contact. Each of the two half shells is angled along its length, an angle of one of the half shells corresponding to an angle of the other of the half shells, allowing the tibia nail and femur nail to extend from the passage at an angle from one another.

Abstract: A modular joint prosthesis includes a nail for insertion into a bone marrow canal, the nail having a nail neck. A neck piece has a proximal end, a middle shaft portion defining a longitudinal axis, and a distal end with a conical pin to which a slip-on joint ball can be attached. The proximal end of the neck piece has a helmet-shaped receiving head that includes an insertion opening for insertion of the nail neck or a module connector, a slot extending in the direction of the longitudinal axis, and corresponding recesses positioned on either side of the slot and extending perpendicularly to the longitudinal axis. The corresponding recesses receive a tensioning means which, in a tensioned state, clampingly fixes the nail neck or the module connector in the receiving head by frictional engagement in a jaw-like manner by application of tightening torque sufficient to prevent axial displacement and rotation.

Abstract: Apparatus for the fixed-angle fixation and compression of a fracture site or osteotomy of a bone includes a bone plate having a plurality of holes and bone screws with a threaded head. The bone screws accommodated in the holes are screwed into the bone. At least one of the holes is a combination of two circular holes of different diameter. As screwing of the bone screw into the bone proceeds through a final stage, engagement of the threads on the head with threads in the combination hole effects relative longitudinal displacement between the plate and the bone whereby it is possible to simplify simultaneous fixed angle fixation and compression of the fracture or osteotomy with use of a single screw. Threads on the head of the bone screw engage threads in the hole which is a combination of the two hole to effect relative motions.

Abstract: Apparatus for the fixed-angle fixation and compression of a fracture site or osteotomy of a bone includes a bone plate having a plurality of holes and bone screws with a threaded head. The bone screws accommodated in the holes are screwed into the bone. At least one of the holes is a combination of two circular holes of different diameter. As screwing of the bone screw into the bone proceeds through a final stage, engagement of the threads on the head with threads in the combination hole effects relative longitudinal displacement between the plate and the bone whereby it is possible to simplify simultaneous fixed angle fixation and compression of the fracture or osteotomy with use of a single screw. Threads on the head of the bone screw engage threads in the hole which is a combination of the two hole to effect relative motions.

Abstract: A joint prosthesis system has a metal shaft, which is implanted in the femur, a throat having an outer cone, a joint ball made of ceramic and an accommodation for the throat. The accommodation has an inner cone, and a sheath-shaped adapter, which is arranged between the shaft and the joint ball in a clamping manner. Due to an exceptional elasticity and a special shaping of an inner and outer wall section of the adapter, the application of force to a narrow surface region on the metal outer cone and the application of the force into the ceramic inner cone is extensively concentrated on a load-bearing region (B) opposite the narrow surface region within the largest mass expansion of the ceramic joint ball.

Abstract: A modular joint prosthesis includes a nail for insertion into a bone marrow canal, the nail Slaving a nail neck. A neck piece has a proximal end, a middle shaft portion defining a longitudinal axis, and a distal end with a conical pin to which a slip-on joint hall can be attached. The proximal end of the neck piece has a helmet-shaped receiving head that includes an insertion opening for insertion of the nail neck or a module connector, a slot extending in the direction of the longitudinal axis, and corresponding recesses positioned on either side of the slot and extending perpendicularly to the longitudinal axis. The corresponding recesses receive a tensioning means which, in a tensioned state. clampingly fixes the nail neck or the module connector in the receiving head by frictional engagement in a jaw-like manner by application of tightening torque sufficient to prevent axial displacement and rotation.

Abstract: A knee arthrodesis implant has a femur nail and a tibia nail. A connecting module has two longitudinally separated half shells that when connected form a passage. One end of the connecting module is coupled to a femur nail neck and the other end is coupled to a tibia nail neck. The half shells have a plurality of corresponding recesses extending perpendicularly to the passage. Each recess receives a tensioning screw, and tightening the tensioning screws couples the femur and tibia nail necks to the connecting module by holding the femur and tibia nail necks within the passage by frictional contact. Each of the two half shells is angled along its length, an angle of one of the half shells corresponding to an angle of the other of the half shells, allowing the tibia nail and femur nail to extend from the passage at an angle from one another.

Abstract: A method and a device are for determining the compatibility between an adapter, which is to be inserted into a third-party joint ball type to be replaced, and an outer cone of a prosthesis shaft of a modular joint prosthesis, which is inserted in the femur during revision surgery. A test body of a set of test bodies having various inner cones, comprising a marker and a length measuring scale, is fitted onto the outer cone of the shaft of the joint prosthesis and, subsequently, the adapter fitting on the outer cone of the joint prosthesis is determined by successively testing the inner cones for compliance with an admissible minimum distance between the front faces of the outer cone of the shaft of the joint prosthesis and the inner cone and for compliance with an admissible predefined insertion depth of the outer cone of the shaft of the joint prosthesis in the inner cone of the test body.

Abstract: The invention relates to modular joint prostheses, comprising a curved head part to the conical pins of which a slip-on joint ball is attached, and comprising a nail which can be inserted into the bone marrow canal of the long bone and has a nail neck, wherein a connecting means is provided between the head part and the nail neck which holds the head part in a non-rotatable manner. The connecting means comprises at least one collar-like module which is located in the axial direction of the nail and has at least two semi-shells, which are divided in the axial direction of the module, are detachably connected to each other, form an axially extending passage for inserting the nail head into the passage and have recesses for receiving a tensioning means, which in the tensioned state fixes the nail head in the passage exclusively by way of factional engagement.

Abstract: A knee arthrodesis implant has a femur nail inserted in the bone marrow canal of the femur, and a tibia nail inserted in the bone marrow canal of the tibia, the nails being rigidly connected to each other by a connecting means. The problem of providing a knee arthrodesis implant having increased modularity as the result of increased length variability, having a reduced number of parts, and allowing simplified modification is addressed.

Abstract: A joint prosthesis system has a metal shaft, which is implanted in the femur, a throat having an outer cone, a joint ball made of ceramic and an accommodation for the throat. The accommodation has an inner cone, and a sheath-shaped adapter, which is arranged between the shaft and the joint ball in a clamping manner. Due to an exceptional elasticity and a special shaping of an inner and outer wall section of the adapter, the application of force to a narrow surface region on the metal outer cone and the application of the force into the ceramic inner cone is extensively concentrated on a load-bearing region (B) opposite the narrow surface region within the largest mass expansion of the ceramic joint ball.

Abstract: Apparatus for the fixed-angle fixation and compression of a fracture site or osteotomy of a bone includes a bone plate having a plurality of holes and bone screws with a threaded head. The bone screws accommodated in the holes are screwed into the bone. At least one of the holes is a combination of two circular holes of different diameter. As screwing of the bone screw into the bone proceeds through a final stage, engagement of the threads on the head with threads in the combination hole effects relative longitudinal displacement between the plate and the bone whereby it is possible to simplify simultaneous fixed angle fixation and compression of the fracture or osteotomy with use of a single screw. Threads on the head of the bone screw engage threads in the hole which is a combination of the two hole to effect relative motions.

Abstract: A method and a device are for determining the compatibility between an adapter, which is to be inserted into a third-party joint ball type to be replaced, and an outer cone of a prosthesis shaft of a modular joint prosthesis, which is inserted in the femur during revision surgery. A test body of a set of test bodies having various inner cones, comprising a marker and a length measuring scale, is fitted onto the outer cone of the shaft of the joint prosthesis and, subsequently, the adapter fitting on the outer cone of the joint prosthesis is determined by successively testing the inner cones for compliance with an admissible minimum distance between the front faces of the outer cone of the shaft of the joint prosthesis and the inner cone and for compliance with an admissible predefined insertion depth of the outer cone of the shaft of the joint prosthesis in the inner cone of the test body.

Abstract: A knee arthrodesis implant has a femur nail inserted in the bone marrow canal of the femur, and a tibia nail inserted in the bone marrow canal of the tibia, the nails being rigidly connected to each other by a connecting means. The problem of providing a knee arthrodesis implant having increased modularity as the result of increased length variability, having a reduced number of parts, and allowing simplified modification is addressed.

Abstract: The invention relates to modular joint prostheses, comprising a curved head part and/or a shaft-like shaped shaft part, to the conical pins of which a slip-on joint ball is attached, and comprising a nail which can be inserted into the bone marrow canal of the long bone and has a nail neck, wherein a connecting means is provided between the head part and the nail neck which holds the head part in a non-rotatable manner. The invention is based on the problem of providing a modular joint prosthesis which increases the modularity of the prosthesis by increased longitudinal variability, enables improved adjustability of the angular position while reducing the number of parts at the same time, and simplifies revision surgeries.