Abstract: Described herein are methods and devices useful for delivering a biologically relevant cargo to biological cells, especially to sensitive cells such as primary stem cells and primary derived cells. The methods and devices may use centrifugation of cells to drive the cells into hollow nano straws on a substrate for delivering the biologically relevant cargo to the cells.

Abstract: Methods and apparatuses to non-destructively and periodically sample a small quantity of intracellular proteins and mRNA from the same single cell or cells for an extended period of time. Specifically, describe herein are non-perturbative methods for time-resolved, longitudinal extraction and quantitative measurement of intracellular proteins and nucleic acids from a variety of cell types using systems including nanostraws.

Abstract: Methods and apparatuses to non-destructively and periodically sample a small quantity of intracellular proteins and mRNA from the same single cell or cells for an extended period of time. Specifically, describe herein are non-perturbative methods for time-resolved, longitudinal extraction and quantitative measurement of intracellular proteins and nucleic acids from a variety of cell types using systems including nanostraws.

Abstract: Nanostraws and to methods of utilizing them in order to deliver biologically relevant molecules such as DNA, RNA, proteins etc., into non-adherent cells such as immune cells, embryos, plant cells, bacteria, yeast etc. The methods described herein are repeatedly capable of delivering biologically relevant cargo into non-adherent cells, with high cell viability, dosage control, unaffected proliferation or cellular development, and with high efficiency. Among other uses, these new delivery methods will allow to scale pre-clinical cell reprogramming techniques to clinical applications.

Abstract: Nanostraws and to methods of utilizing them in order to deliver biologically relevant molecules such as DNA, RNA, proteins etc., into non-adherent cells such as immune cells, embryos, plant cells, bacteria, yeast etc. The methods described herein are repeatedly capable of delivering biologically relevant cargo into non-adherent cells, with high cell viability, dosage control, unaffected proliferation or cellular development, and with high efficiency. Among other uses, these new delivery methods will allow to scale pre-clinical cell reprogramming techniques to clinical applications.

Abstract: Methods and apparatuses to non-destructively and periodically sample a small quantity of intracellular proteins and mRNA from the same single cell or cells for an extended period of time. Specifically, describe herein are non-perturbative methods for time-resolved, longitudinal extraction and quantitative measurement of intracellular proteins and nucleic acids from a variety of cell types using systems including nanostraws.

Abstract: Nanostraws and to methods of utilizing them in order to deliver biologically relevant molecules such as DNA, RNA, proteins etc., into non-adherent cells such as immune cells, embryos, plant cells, bacteria, yeast etc. The methods described herein are repeatedly capable of delivering biologically relevant cargo into non-adherent cells, with high cell viability, dosage control, unaffected proliferation or cellular development, and with high efficiency. Among other uses, these new delivery methods will allow to scale pre-clinical cell reprogramming techniques to clinical applications.

Abstract: The present invention relates to a stand-alone therapeutical training device which is peculiar in that the stand-alone therapeutical training device comprising a shallow housing having at least a top surface and a bottom surface, said housing comprising at least one force sensor, said force sensor measuring the force applied to said top surface of said housing and generating a response signal, at least one user feedback unit, a controller placed inside said housing configured for controlling said user feedback unit and that the controller controls the user feedback unit proportionally to said response signal from said force sensor. Hereby can be archived a simple stand-alone therapeutically training device enabling the patient and/or the physiotherapist to evaluate the force or weight applied by the user on the upper surface of the device.

Abstract: The present invention relates to an exercise apparatus for exercising muscle groups in a person's legs by stretching and/or retraction, which exercise apparatus comprises at least a first frame and at least a first foot platform which foot platform is rotatable fastened to a hearing, which hearing is placed in relation to the person's foot for exercise at least plantar flexion and/or dorsal flexion, which exercise apparatus further includes a leg support. Hereby can be achieved exercising of the muscle groups by stretching and/or retraction (quadriceps lemons, biceps femoris, semitendinosus, semimembranosus, gastrocnememius, tibialis posterior, tibialis anterior, peroneus longus, peroneus brevis and soleus) in the legs of a person, and the muscles (soleus, gastrocnemius, tibialis posterior, peroneus brevis, peroneus longus, biceps femoris, semitendinosus, semimembranosus) at the back side of the legs.

Abstract: The present invention relates to a stand-alone therapeutical training device which is peculiar in that the stand-alone therapeutical training device comprising a shallow housing having at least a top surface and a bottom surface, said housing comprising at least one force sensor, said force sensor measuring the force applied to said top surface of said housing and generating a response signal, at least one user feedback unit, a controller placed inside said housing configured for controlling said user feedback unit and that the controller controls the user feedback unit proportionally to said response signal from said force sensor. Hereby can be archived a simple stand-alone therapeutically training device enabling the patient and/or the physiotherapist to evaluate the force or weight applied by the user on the upper surface of the device.

Abstract: The present invention relates to an exercise apparatus for exercising muscle groups in a person's legs by stretching and/or retraction, which exercise apparatus comprises at least a first frame and at least a first foot platform which foot platform is rotatable fastened to a hearing, which hearing is placed in relation to the person's foot for exercise at least plantar flexion and/or dorsal flexion, which exercise apparatus further includes a leg support. Hereby can be achieved exercising of the muscle groups by stretching and/or retraction (quadriceps lemons, biceps femoris, semitendinosus, semimembranosus, gastrocnememius, tibialis posterior, tibialis anterior, peroneus longus, peroneus brevis and soleus) in the legs of a person, and the muscles (soleus, gastrocnemius, tibialis posterior, peroneus brevis, peroneus longus, biceps femoris, semitendinosus, semimembranosus) at the back side of the legs.