Abstract: The present invention relates injection device for introducing a substance into tissue of a subject, the injection device comprising: (a) an application element (10); (b) a housing (50) having a receptacle for holding a syringe; (c) an electromechanical drive device system arranged to advance a piston for the syringe, and (d) a cooling assembly comprising a cooling plate (40), wherein the cooling plate (40) is incorporated into the application element (10). Moreover, the present invention also relates to a needle housing, liner and syringe specifically designed for fitting in the injection devices, according to the present invention or to be coupled thereto. Finally, the present invention relates to a method for introducing a substance into a tissue of a subject.

Abstract: A measuring system based on micromechanical elements, including an energy converter which is configured to convert a physical signal into a displacement of the energy converter, a force generator which is configured to convert the displacement from the energy converter into a force on a movably mounted slider, and an electrostatic actuator which is mechanically connected to the slider and/or an electrostatic anti-spring which is mechanically connected to the slider, and an electromechanical signal converter which converts a displacement of the slider into an electrical signal, the electrostatic actuator being configured to convert the displacement from the energy converter into a force on a movably mounted slider, which is mechanically connected to the slider, and an electromechanical signal converter which converts a displacement of the slider into an electrical signal, wherein the electrostatic actuator is configured to set an offset compensation of the measuring system via a control voltage and/or the elec

Abstract: The present invention is related to a kit (K), comprising a composition for preparing an oxygen barrier coating (1c) comprising a polymer having reactive hydroxyl groups, and a composition for preparing a layer selected from the group consisting of an ink layer (1b), an overprint varnish layer (1h) and an adhesive layer (1i), wherein composition b) comprises a component that is capable of crosslinking with the polymer of composition a) when compositions a) and b) are applied one after another onto an uncoated or coated substrate (1a).

Abstract: An electric motor of an auxiliary unit of a motor vehicle, in particular an electromechanical brake booster, contains a bearing shield and a sensor carrier manufactured from a plastic. The sensor carrier has a body arranged perpendicularly to an axis of rotation, to which a sensor is mounted and to which arms extending at least partly parallel to the axis of rotation are connected on the edge side. The arms are fastened to the bearing shield.

Abstract: The present invention is directed to a substantially anhydrous composition for keratin fibers especially for human hair comprising one or more polyol other than the glyceryl ether, one or more amine and/or quaternary ammonium surfactant, one or more fatty alcohol, one or more glyceryl ether according to the general structure wherein R1 is straight or branched, saturated or unsaturated alkyl chain with 4 to 18 C atoms, wherein the total concentration of water is not more than 10% by weight, calculated to the total weight of the composition, wherein the composition comprises one or more polyol at a concentration of at least 40% by weight, calculated to the total weight of the composition, and wherein the one or more glyceryl ether according to the above general structure is selected from ethylhexyl glycerin, hexylglycerin, heptylglycerin, methylheptylglycerin.

Abstract: A passive micromechanical counter for counting and storing a number of mechanical pulses includes at least one memory cell, the memory cell having a cell input, a latching mechanism and an electromechanical coding unit, the cell input being designed to mechanically transmit the mechanical pulse to the latching mechanism, and the latching mechanism being designed to store the number of mechanical pulses transmitted by means of its discrete latching position. It is provided that an electrical digital signal can be generated by applying an electrical voltage to the electromechanical coding unit, the electrical digital signal representing the discrete latching position of the latching mechanism.

Abstract: An earpad comprising one or more acoustic resonators coupled to a contact face of the earpad that is configured to interface with a user's head, the acoustic resonators being configured to attenuate leakage of parasitic sound.

Abstract: A device comprising: an acoustic metamaterial (AMM), wherein the phase velocity of an acoustic wave is reduced at low frequencies as compared to the phase velocity at higher frequencies; a microphone array (MIC) of at least two microphones (mic1, mic2) embedded in the acoustic metamaterial (AMM) and configured to detect acoustic waves.

Abstract: The present invention relates to methods for diagnosing, staging and treating cancer, in particular melanoma. In particular, the present invention provides methods for determining the stage/type of a cancerous disease, comprising detecting somatic alterations of the DNA of one or more disseminated cancer cells (DCCs), obtained after homing to a distant organ, such as lymph node; and determining the somatic evolution of the DCC(s) based on the detected somatic alterations, wherein the somatic evolution is indicative of the stage/type of the cancerous disease.

Abstract: An electronic device comprising circuitry configured to separate by audio source separation a first audio input signal into a first vocal signal and an accompaniment, and to transpose an audio output signal by a transposition value based on a pitch ratio, wherein the pitch ratio is based on comparing a first pitch range of the first vocal signal and a second pitch range of the second vocal signal.

Abstract: An electronic device having a circuitry configured to perform audio source separation on an audio input signal to obtain a separated source and configured to perform audio dubbing on the separated source based on replacement conditions to obtain a personalized separated source.

Abstract: An electronic device having a circuitry configured to perform audio source separation on an audio input signal to obtain a vocals signal and an accompaniment signal and to perform a confidence analysis on a user's voice signal based on the vocals signal to provide guidance to the user.

Abstract: The invention relates to a two-part hinge device for a door or a window, comprising a first housing part (20) and a second housing part (30), which in the assembled state form a door hinge housing (19), and a rod (15) which extends in the first housing part (20) and second housing part (30) along the axial direction (60) thereof, wherein the rod (15) has at least three successive—a first, a second and a third—rod sections (16, 17, 18). The first rod section (16) is supported in the first housing part (20) by a clamping element (50), and the third rod section (18) supports the second housing part (30). In the region of the second rod section (17), the rod (15) is adjustable relative to the first housing part (20) in two directions at an angle to each other and independently of each other, and the two directions at an angle to each other are arranged transversely to the axial direction (60) of the rod (15).

Abstract: A passive micromechanical counter for counting and storing a number of mechanical pulses includes at least one memory cell, the memory cell having a cell input, a latching mechanism and an electromechanical coding unit, the cell input being designed to mechanically transmit the mechanical pulse to the latching mechanism, and the latching mechanism being designed to store the number of mechanical pulses transmitted by means of its discrete latching position. It is provided that an electrical digital signal can be generated by applying an electrical voltage to the electromechanical coding unit, the electrical digital signal representing the discrete latching position of the latching mechanism.

Abstract: Processes treat hair with aqueous compositions comprising one or more cationic polymers having certain cationic change densities and one or more aminated silicones. The novel processes provide long lasting conditioning to the hair and improve combability and suppleness of the hair which is maintainable up to twenty subsequent hair washes.

Abstract: The application relates to a medical instrument with a hollow shaft, with a handle at the proximal end and a tool with two jaw parts at the distal end, of which at least one jaw part is pivotable, wherein a distal end region of the shaft is configured as a deflectable, rotatable tool tip, and wherein the jaw parts are adjustable between closed and open positions, wherein rotation of the tool tip and actuation of the jaw parts take place via actuation elements coupled at the proximal end to the handle. The distal end of the shaft and the proximal end of the tool tip are arc-shaped, and roll on each other for the deflection of the tool tip, and are conveyed from the shaft into the deflectable tool tip via at least two identical joints, which are connected in series and which can transmit rotation and translatory movements.

Abstract: Processes condition human hair by applying an aqueous composition onto the human hair such that the conditioned human hair achieves long lasting conditioning of the human hair and increasing hair temperature of the conditioned human hair to the range of 40 to 140° C., wherein the aqueous composition comprises one or more cationic quaternary ammonium polymers having a cationic charge density of 3.0 mEq/g or more and one or more nonionic surfactants.

Abstract: The application relates to a medical instrument with a hollow shaft, with a handle at the proximal end and a tool with two jaw parts at the distal end, of which at least one jaw part is pivotable, wherein a distal end region of the shaft is configured as a deflectable, rotatable tool tip, and wherein the jaw parts are adjustable between closed and open positions, wherein rotation of the tool tip and actuation of the jaw parts take place via actuation elements coupled at the proximal end to the handle. The distal end of the shaft and the proximal end of the tool tip are arc-shaped, and roll on each other for the deflection of the tool tip, and are conveyed from the shaft into the deflectable tool tip via at least two identical joints, which are connected in series and which can transmit rotation and translatory movements.

Abstract: A sea water cooling system including a first fluid cooling loop coupled to a first side of a heat exchanger and to a thermal load, a second fluid cooling loop coupled to a second side of the heat exchanger and including a pump for circulating fluid through the second fluid cooling loop, and a controller operatively connected to the pump, wherein the controller is configured to monitor an actual temperature in the first fluid cooling loop and to adjust a speed of the pump based on the monitored temperature to achieve a predetermined temperature in the first fluid cooling loop. The system may be selectively operable in one of a plurality of operating modes, wherein in a first operating mode the pump operates based entirely on cooling demands of the thermal load, and in a second operating mode the pump operates to maintain a fluid pressure above a predefined pressure.

Abstract: A sea water cooling system including a first fluid cooling loop coupled to a first side of a heat exchanger and to a thermal load, a second fluid cooling loop coupled to a second side of the heat exchanger and including a pump for circulating fluid through the second fluid cooling loop, and a controller operatively connected to the pump, wherein the controller is configured to monitor an actual temperature in the first fluid cooling loop and to adjust a speed of the pump based on the monitored temperature to achieve a predetermined temperature in the first fluid cooling loop. The system may be selectively operable in one of a plurality of operating modes, wherein in a first operating mode the pump operates based entirely on cooling demands of the thermal load, and in a second operating mode the pump operates to maintain a fluid pressure above a predefined pressure.