Abstract: Provided herein are methods of employing pharmacodynamics regimens to maximize effectiveness of voclosporin in treatment of proteinuric kidney diseases while minimizing undesirable side effects, such as but not limited to calcineurin inhibitor nephrotoxicity. Also provided are methods of assessments of renal functions and/or conditions, and corresponding protocols to modify, stop, restore and/or re-initiate voclosporin dosing and administrations to maximize effectiveness of voclosporin in treatment of proteinuric kidney diseases while minimizing undesirable side effects.

Abstract: A method of and apparatus for bending and tempering a relatively thin glass sheet while supported horizontally and conveyed along a generally horizontal path comprising heating the glass sheet to its softening point, bending the sheet into the desired curvature, reorienting the bent sheet for further processing along said horizontal path, reheating the sheet to the temperature necessary for proper tempering, and finally, chilling the sheets rapidly below the annealing temperature range of the glass.