Abstract: The present invention is related to a method for recovering two or more genes, or gene products, or cDNAs, encoding for an immunoreceptor having two or more subunits, which two or more genes, or gene products, are comprised in a given source cell. The invention is further related to a method of creating a library of expressor cells, in which library each cell is capable of expressing two or more genes, or gene products, encoding for the subunits of the immunoreceptor. The invention is further related to a method of screening a library of expressor cells as created according to the above method, for one cell that expresses an immunoreceptor that has specificity for a given target molecule.

Abstract: Methods and apparatus for processing a substrate are provided herein. A method, for example, includes igniting a plasma at a first pressure within a processing volume of a process chamber; depositing sputter material from a target disposed within the processing volume while decreasing the first pressure to a second pressure within a first time frame while maintaining the plasma; continuing to deposit sputter material from the target while decreasing the second pressure to a third pressure within a second time frame less than the first time frame while maintaining the plasma; and continuing to deposit sputter material from the target while maintaining the third pressure for a third time frame that is greater than or equal to the second time frame while maintaining the plasma.

Abstract: The invention relates to a method for obtaining an N-acetylglucosamine containing neutral oligosaccharide from a fermentation broth, wherein said oligosaccharide is produced by culturing a genetically modified microorganism capable of producing said oligosaccharide from an internalized carbohydrate precursor, comprising the steps of: i) ultrafiltration (UF), preferably to separate biomass from the broth, ii) nanofiltration (NF), preferably to concentrate said oligosaccharide in the broth and/or reduce an inorganic salt content of the broth, and iii) treating the broth with an ion exchange resin, preferably to remove charged materials, and/or subjecting the broth to chromatography, preferably to remove hydrophobic impurities.

Abstract: A tube stabilising device (10, 20, 30) for a tube attached to a patient, comprising a base member (110, 210, 310) fixable to a surface, the base member having a support surface (112, 212, 312) for supporting the base member on a surface of the patient. The tube stabilising device further comprising a tube retaining member (120, 220, 320). The base member includes a cavity (114, 214, 314) configured to receive a flange (122, 222, 322) of the tube retaining member such that, when received, the cavity at least partially overlaps the flange so that the flange is retained by the base member, the tube retaining member is moveably attached to the base member and the flange is moveable within the cavity in any direction parallel to the support surface. The tube retaining member is configured to retain a tube extending from the patient such that, when retained, the tube is moveable relative to the base member.

Abstract: In one example in accordance with the present disclosure, a fluidic die is described. The fluidic die includes an array of firing subassemblies grouped into zones. Each firing subassembly includes 1) a firing chamber, 2) a fluid actuator, and 3) a sensor plate. The fluidic die also includes a measurement device per zone to measure a voltage indicative of an impedance within a selected firing chamber. The fluidic die includes a selector per firing subassembly to couple a selected sensor plate to the measurement device. A selector is adjacent a respective firing subassembly and a distance between the selector and the measurement device is different as compared to other selectors.

Abstract: A caliper guide assembly for a heavy vehicle disc brake. The caliper guide assembly may include a wear sensor arranged to detect the position of a guide pin in relation to a guide bore. The guide pin and a guide surface may have different cross sectional profiles to define at least one void therebetween. The wear sensor may be at least partially accommodated within the void.

Abstract: A method includes: determining, by a computer device, a current context associated with a user that is the target audience of an unprompted verbal output of an interactive computing device; determining, by the computer device, one or more parameters that are most effective in getting the attention of the user for the determined current context; and modifying, by the computer device, the unprompted verbal output of the interactive computing device using the determined one or more parameters.

Abstract: A synchronous dynamometer assembly for applying a load to an engine during at least one portion of the combustion cycle of the engine in a synchronised manner so as to be repeatable each cycle of the engine comprises a dynamometer having a non-inductive load which is applied to the engine during operation to vary the speed of the engine. The non-inductive load is variable by varying the current delivered to it. Crankshaft monitoring means monitors the rotational position of the engine crankshaft, and combustion detection means detects a combustion event in a cylinder of the engine. Control means is operatively connected to the dynamometer for applying the load from the dynamometer to the engine for at least one part of the combustion cycle in real time such that the different loads may be applied to the engine for different parts of the combustion cycle.

Abstract: Polymorphs of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein. Also provided herein are processes for preparing compounds, polymorphs thereof, and pharmaceutical compositions thereof.

Abstract: Systems, devices, and methods for tracking eye movement and gaze direction using infrared light are described. The method includes projecting infrared light from at least one pixel in the display screen to the eye of the user, detecting a plurality of reflections of the infrared light from the eye, determining the relative intensity of each of the plurality of the reflections, identifying, from the plurality of reflections, a region of the eye that corresponds to a relatively low intensity reflection, and determining a position of the eye based on the region of the eye that corresponds to the relatively low intensity reflection.

Abstract: Methods, computer program products, and systems are presented. The methods computer program products, and systems can include, for instance: obtaining emergency event data and user data of a mobile device user, wherein the user data of the mobile device user includes user biometric data obtained from a mobile device of the mobile device user; examining data of the emergency event data and data of the user data; and responsively to the examining, automatically outputting one or more text based status message.

Abstract: Methods and systems, including computer programs encoded on a computer storage medium, are used for generating an identification document comprising an image of an individual, personal information associated with the individual, and line patterns that include multiple distinct square-wave lines. The square-wave lines enable credential data about a person assigned to the identification document to be securely stored at the identification document. A first portion of distinct square-wave lines are used to encode a first item of credential data and to determine whether the image of the individual corresponds to the first item of credential data. A second portion of distinct square-wave lines are used to encode a second item of credential data and to determine whether the personal information corresponds to the second item of credential data.

Abstract: The present invention lies in the fields of chemistry and materials engineering. More specifically, the present invention describes a process of heat treatment of polymeric precursors including as active phases particle charge or a mixture of active phases with inert phases called “fillers”. It is also described a surface including ceramic polymer obtained by said process. The volumetric positive variation resulting from the formation of new phases, which for their formation, incorporate atoms from the gaseous phase, contributes to a minor shrinkage of the composition during the heat treatment process. The process of the present invention allows obtaining the desired phases in smaller treatment times and lower temperatures, when compared to a thermal treatment process as conventional pyrolysis (PC) due to the presence of highly reactive species, as for example atomic nitrogen produced by the dissociation of nitrogen molecules in the plasma environment.

Abstract: Methods for the treatment of patients with both Chronic Obstructive Pulmonary Disease (COPD) and pulmonary fibrosis, and of patients with idiopathic pulmonary fibrosis without COPD, by stimulating the synthesis of human and animal patient lung and sinus surfactants to increase lung functions, inhibiting fibrosis and reducing coughing and nasal erythema, include the following steps: A) analyzing and diagnosing a patient with a lung ailment selected from the group consisting of i) both COPD and pulmonary fibrosis; and ii) idiopathic pulmonary fibrosis without COPD; and, B) treating the patient to raise the patient's lung functions including FEV1/FVC ratio by contacting mammalian cells with a [therapeutically effective amount of a treatment] composition that includes: a) a pyruvate salt; b) a phosphate; c) a salt of calcium; and d) a salt of magnesium, in an aqueous carrier, containing no more than 2.2 grams of said pyruvate salt per liter.

Abstract: In an embodiment, an apparatus includes one or more probes, a tip, a pin, and a measurement device. The one or more probes may be configured for insertion through an aperture in a component. The tip may be slidably engaged with the one or more probes and include a first end configured to contact a first surface of the component. The first end of the tip may be conically shaped. The pin may be slidably engaged with the one or more probes and include a first end configured for insertion into the aperture in the component such that the one or more probes are configured to contact a second surface of the component. The pin may be configured to move between a first position and a second position. An axis of the pin may be substantially aligned with an axis of the tip. The measurement device may be coupled to the tip and configured to measure a value indicating a grip length.

Abstract: There is provided a solid-state battery layer structure which may include an anode current collector metal layer, an anode layer arranged on the anode current collector metal layer, a solid electrolyte layer arranged on the anode layer laterally, a cathode layer arranged on the solid electrolyte layer, and a cathode current collector metal layer, and a plurality of nanowire structures comprising silicon and/or gallium nitride, wherein said nanowire structures are arranged on the anode layer and, wherein said nanowire structures are laterally and vertically enclosed by the solid electrolyte layer, wherein the anode layer comprises silicon and a plurality of metal vias connecting the plurality of nanowire structures with the anode current collector metal layer. Methods for producing solid-state battery layer structures are also provided.

Abstract: Aspects of the present disclosure include systems for use in preparing an epitope tagged biomolecule reagent. A reagent preparatory apparatus for preparing the epitope tagged biomolecule reagent from an activated biomolecule and activated epitope tag is also described. Methods for communicating and receiving an epitope tagged biomolecule reagent request and preparing the subject epitope tagged biomolecule reagents are also provided.

Abstract: The present invention relates to a method with which the driving dynamics of an electrically driven vehicle can be modified. Within the scope of the method according to the invention, a vehicle operating characteristic variable, as a function of which a torque transmission mechanism is engaged, is monitored, by means of which torque transmission mechanism two half-shaft assemblies of the vehicle which are each driven by an electric motor can be selectively connected to one another in terms of drive.