Abstract: Described herein are ASK1 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with ASK1 activity.

Abstract: A foil for a towed cable includes a body defining at least two conduits. The body has a foil shape having a leading edge and a trailing edge. The foil shape defines a first surface extending between the leading edge and the trailing edge configured to provide lift. The foil shape defines a second surface opposed to the first surface extending between the leading edge and the trailing edge. The foil shape defines first and second lateral sides that extend between respective lateral edges of the first and second surfaces, the leading edge, and the trailing edge. A first conduit is defined within the forward half of the body adjacent to the leading edge, is open to each of the first and second lateral sides, and is configured to receive a cable therethrough. A second conduit may be defined within the body and filled with buoyant material.

Abstract: A modular firing range includes a first subset of modular containers that form a first end of the firing range. The first subset includes outer walls that define the first end of the firing range and side walls that define a portion of a side of the firing range. A second subset of modular containers form a second end of the firing range. The second subset includes outer walls that define the second end of the firing range and side walls that define a portion of the side of the firing range. A third subset of modular containers is coupleable between the first subset and the second subset to form a medial portion of the firing range. The third subset includes outer walls that define a portion of the side of the firing range. The firing range includes an armored outer perimeter that provides complete ballistic containment in all directions.

Abstract: Burst performance of a database query may be determined according to a size of the database query. A query to a database may be received. A size may be determined for the query. If the size is less than a size threshold assigned to a first query engine, then the query may be performed at the first query engine. If the size is greater than or equal to the size threshold assigned to the first query engine, then the query may be performed at a second query engine.

Abstract: A combustion air intake apparatus for a truck, tractor, or bus vehicle for highway use includes an air deflecting element that is selectively deployable to cause dynamic air pressure created by vehicle motion to increase static air, pressure within the intake apparatus under appropriate conditions. Deployment or retraction of the air deflecting element is responsive to at least one of forward speed of the vehicle, air pressure downstream of an air inlet opening, or throttle position, and may further be responsive to detection of precipitation and/or particulate material. An air deflecting element may include a moveable plate or flap, moveable louvers, or a moveable duct.

Abstract: A clip for reducing a dimension of an opening in tissue may include a continuous member having a plurality of legs and a plurality of preformed bends connecting adjacent legs, wherein the plurality of legs form: a first group having two protrusions; a second group having two protrusions; and a third group having two protrusions, wherein each protrusion of each group includes two legs of the continuous member and a corresponding preformed bend connecting the two legs, and each protrusion of each group extends from a region adjacent a first end of the clip to a region adjacent a second end of the clip.

Abstract: In one embodiment, a traffic inspection service executed by an intermediary device obtains, from a monitoring agent executed by an endpoint device, keying information for an encrypted traffic session between the endpoint device and a remote entity. The traffic inspection service provides a notification to the monitoring agent that acknowledges receipt of the keying information. The traffic inspection service uses the keying information to decrypt encrypted traffic from the encrypted traffic session. The traffic inspection service applies a policy to the encrypted traffic session between the endpoint device and the remote entity, based on the decrypted traffic from the session.

Abstract: An overlay metrology target (600, 900, 1000) contains a plurality of overlay gratings (932-935) formed by lithography. First diffraction signals (740(1)) are obtained from the target, and first asymmetry values (As) for the target structures are derived. Second diffraction signals (740(2)) are obtained from the target, and second asymmetry values (As?) are derived. The first and second diffraction signals are obtained using different capture conditions and/or different designs of target structures and/or bias values. The first asymmetry signals and the second asymmetry signals are used to solve equations and obtain a measurement of overlay error. The calculation of overlay error makes no assumption whether asymmetry in a given target structure results from overlay in the first direction, in a second direction or in both directions. With a suitable bias scheme the method allows overlay and other asymmetry-related properties to be measured accurately, even in the presence of two-dimensional overlay structure.

Abstract: The present invention relates to a positioning system for the hyperloop means of transport that comprises a group of readers installed on the pod that query the infrastructure by means of electromagnetic or pressure waves. Along the length of the route of the tube through which the pod travels, there is information encoded by passive elements that make up a message that is readable by the sensors. Once the message has been decoded, it is possible to determine the longitudinal forward movement of the pod and its rotation with respect to the longitudinal axis of the tube, because the tube presents different information encoded both longitudinally and angularly.

Abstract: The invention relates to the use of an alloy having the composition (in mass %) of: Cr 20.0 to 23.0%, Mo 18.5 to 21.05%, Fe?1.5%, Mn?0.5%, Si?0.1%, Co?0.3%, W?0.3%, Cu?0.5%, Al?0.4%, C?0.01%, P?0.015%, S?0.01%, N 0.02 to 0.15%, if necessary V?0.3%, Nb?0.2%, Ti?0.02%, the rest Ni and further smelting-related impurities as cladding material in the field of thermal reprocessing systems and substitute-material combustion systems.

Abstract: A method for influencing the efficiency of an electrical grid includes coordinating operation of a first electrified vehicle and a second electrified vehicle traveling along an inductive roadway and having opposite power needs in a manner that influences an amount of energy supplied by the electrical grid during an inductive roadway event.

Abstract: The present disclosure is directed to a method and a system for identifying a communication port in a telecommunication network. The technology allows a field network operator to connect a network termination device (NTD) to a network access node (NAN) of the telecommunication network and automatically receive, on a mobile communication device, information related to physical and logical location of the communication port where the NTD is connected.

Abstract: An extrusion resistant gasket may have a metallic core having a first side and a second side. The metallic core may have a plurality of alternating domes and valleys integrally formed therein. The domes and valleys do not have perforations through the core. The gasket may also have a non-metallic facing material on at least one of the sides of the metallic core. The facing material may have a contact surface and an inner surface. The domes or valleys do not extend through the contact surface.

Abstract: A method for operating a wind power installation which is connected to a network connection point of an electrical supply network and is intended to produce and feed electrical energy into the electrical supply network, wherein the electrical supply network has a network nominal frequency and is operated at a network frequency, and the wind power installation which comprises an electrical generator with a generator nominal power can be regulated on the basis of the network frequency, comprising the steps of: using the electrical generator to produce an electrical generator power for feeding into the electrical supply network, feeding the electrical generator power or a part of it into the electrical supply network as electrical feed-in power on the basis of the network frequency, wherein, in a first supporting stage, the electrical generator power is reduced on the basis of the network frequency in order to accordingly reduce the electrical feed-in power, and, in a second supporting stage, the electrical feed

Abstract: The invention provides genetic constructs and recombinant vectors comprising such constructs. The constructs and vectors can be used in gene therapy methods for the treatment, prevention or amelioration of a neurodegenerative disorder, including Alzheimer's disease, Parkinson's disease, Huntington's disease, motor neurone disease, or for the treatment of stroke, or for promoting nerve regeneration and/or survival.

Abstract: A drive circuit for driving an electronically commutated motor includes an AC terminal to which a power supply grid is connectable, a rectifier connected on the input side to the AC terminal, an inverter connected on the input side to the rectifier and to which the motor phases of the motor are connectable, and an intermediate DC voltage circuit between the rectifier and the inverter. An EMC filter includes a capacitive feedback coupling having at least one Y-capacitor connected between one pole of the intermediate DC voltage circuit and protective ground and overall incorporating stronger insulation than basic insulation.

Abstract: An inspection device for inspecting a cable end of a cable, with and without a connected crimp contact, includes a mirror arrangement having a central axis along which the cable end can be arranged for inspection. The mirror arrangement includes a plurality of mirrors arranged at a predetermined angle to one another and at a predetermined angle to the central axis, each mirror viewing the cable end from a different angle. The inspection device includes a camera for generating images of the cable end from the different viewing angles of the mirrors. A transparent disk is arranged between the camera and the mirror arrangement to prevent dirt and/or dust from moving from the mirror arrangement to the camera. A compressed air cleaning device cleans the disk and/or the mirrors with compressed air ejected along the disk and/or along at least a part of the mirrors.

Abstract: The present invention relates to filter material for inclusion in a smoking article, said filter material comprising a base material comprising or made from fibres having a first diameter or mean diameter, and fine fibres having a diameter or mean diameter which is smaller than the first diameter, wherein the filter material comprises more than 10% by weight and/or by volume fine fibres or wherein the diameter or mean diameter of the fine fibres is between about 1.0 ?m and about 1.5 ?m. The invention also relates to filters or filter elements comprising the filter material, smoking articles comprising the same, and use of the filter material in smoke filtration.

Abstract: In a method for detecting a motor phase fault of a motor arrangement, the motor phases of which are connected to a drive circuit having a DC voltage intermediate circuit and an inverter. A motor phase voltage at at least one of the motor phases with respect to a reference potential is captured while the inverter is switched off; and a voltage profile of the captured motor phase voltage is used to determine whether there is a motor phase fault on one of the motor phases of the motor arrangement.

Abstract: A high density, high polydispersity polyethylene having improved properties, and a process of producing same.