Patents by Inventor Martin J. Mangino

Martin J. Mangino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR RESTORING OR INCREASING TISSUE PERFUSION
    Publication number: 20220387478
    Abstract: A composition for restoring or increasing tissue perfusion is provided. The composition includes polyethylene glycol polymers (PEG) with a molecular weight of 18,000-100,000 Da at a concentration of 5-20% by weight; PEG with a molecular weight of 1,000-10,000 Da at a concentration of 1-30% by weight; and water, wherein said PEG with a molecular weight of 18,000-100,000 Da and said PEG with a molecular weight of 1,000-10,000 Da are dissolved or dispersed in said water.
    Type: Application
    Filed: September 23, 2020
    Publication date: December 8, 2022
    Inventors: Martin J. MANGINO, Loren K. LIEBRECHT
  • POLYMER AGENTS FOR CARDIOPULMONARY RESUSCITATION
    Publication number: 20220175823
    Abstract: A method for resuscitation of the heart in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a solution comprising polyethylene glycol (PEG) having a molecular weight of 8-100 kDa is provided.
    Type: Application
    Filed: March 27, 2020
    Publication date: June 9, 2022
    Inventors: Martin J. MANGINO, Joseph OMATO, Wanchun TANG, Jennifer BRADLEY
  • Compositions and methods for restoring or increasing tissue perfusion
    Patent number: 11007227
    Abstract: A composition for restoring or increasing tissue perfusion is provided. The composition includes polyethylene glycol polymers (PEG) with a molecular weight of 18,000-100,000 Da at a concentration of 5-20% by weight; PEG with a molecular weight of 1,000-10,000 Da at a concentration of 1-30% by weight; and water, wherein said PEG with a molecular weight of 18,000-100,000 Da and said PEG with a molecular weight of 1,000-10,000 Da are dissolved or dispersed in said water.
    Type: Grant
    Filed: September 23, 2020
    Date of Patent: May 18, 2021
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Martin J. Mangino, Loren K. Liebrecht
  • COMPOSITIONS AND METHODS FOR RESTORING OR INCREASING TISSUE PERFUSION
    Publication number: 20210008115
    Abstract: A composition for restoring or increasing tissue perfusion is provided. The composition includes polyethylene glycol polymers (PEG) with a molecular weight of 18,000-100,000 Da at a concentration of 5-20% by weight; PEG with a molecular weight of 1,000-10,000 Da at a concentration of 1-30% by weight; and water, wherein said PEG with a molecular weight of 18,000-100,000 Da and said PEG with a molecular weight of 1,000-10,000 Da are dissolved or dispersed in said water.
    Type: Application
    Filed: September 23, 2020
    Publication date: January 14, 2021
    Inventors: Martin J. Mangino, Loren K. Liebrecht
  • In-situ preservation (ISP) bridge method and solution for non-heart beating donors
    Patent number: 8067150
    Abstract: A method for rapid, in-situ flushing of organs of a non-heart beating donor, and solutions for carrying out the flushing, are provided. The method initiates organ preservation, and the solutions are formulated to counteract basic mechanisms of ischemic cell injury, and to activate known biochemical survival pathways in the cell. Viability of the organ for transplant is thus maintained.
    Type: Grant
    Filed: January 9, 2007
    Date of Patent: November 29, 2011
    Assignee: Virginia Commonwealth University
    Inventor: Martin J. Mangino
  • IN-SITU PRESERVATION (ISP) BRIDGE METHOD AND SOLUTION FOR NON-HEART BEATING DONORS
    Publication number: 20090298043
    Abstract: A method for rapid, in-situ flushing of organs of a non-heart beating donor, and solutions for carrying out the flushing, are provided. The method initiates organ preservation, and the solutions are formulated to counteract basic mechanisms of ischemic cell injury, and to activate known biochemical survival pathways in the cell. Viability of the organ for transplant is thus maintained.
    Type: Application
    Filed: January 9, 2007
    Publication date: December 3, 2009
    Inventor: Martin J. Mangino