Patents by Inventor Martin J. Schnermann

Martin J. Schnermann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conformational restriction of cyanine fluorophores in far-red and near-IR range
    Patent number: 11707537
    Abstract: Conformationally restricted cyanine fluorophores, as well as methods of making and using the compounds, are described. The conformationally restricted cyanine fluorophores have a chemical structure according to Formula I, or a stereoisomer or pharmaceutically acceptable salt thereof: wherein A is and wherein each “*” designates an attachment point of A.
    Type: Grant
    Filed: March 10, 2021
    Date of Patent: July 25, 2023
    Assignee: The USA, as represented by the Secretary, Department of Health and Human Services
    Inventors: Martin J. Schnermann, Megan S. Michie
  • Water soluble novel cyanine fluorophore with tunable properties between near IR and SWIR region for in vivo imaging
    Patent number: 11465993
    Abstract: Cyanine fluorophores including a nine-carbon polymethine bridge are disclosed. The cyanine fluorophores have absorbance and/or emission maxima in the near-infrared (NIR) and short-wave infrared (SWIR) wavelength ranges. Methods of making and using the cyanine fluorophores are also disclosed. The compounds are useful in fluorescence imaging, more particularly in cancer treatment.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: October 11, 2022
    Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: Martin J. Schnermann, Venu G. Bandi
  • CONFORMATIONAL RESTRICTION OF CYANINE FLUOROPHORES IN FAR-RED AND NEAR-IR RANGE
    Publication number: 20210220490
    Abstract: Conformationally restricted cyanine fluorophores, as well as methods of making and using the compounds, are described. The conformationally restricted cyanine fluorophores have a chemical structure according to Formula I, or a stereoisomer or pharmaceutically acceptable salt thereof: wherein A is and wherein each “*” designates an attachment point of A.
    Type: Application
    Filed: March 10, 2021
    Publication date: July 22, 2021
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Martin J. Schnermann, Megan S. Michie
  • WATER SOLUBLE NOVEL CYANINE FLUOROPHORE WITH TUNABLE PROPERTIES BETWEEN NEAR IR AND SWIR REGION FOR IN VIVO IMAGING
    Publication number: 20210179597
    Abstract: Cyanine fluorophores including a nine-carbon polymethine bridge are disclosed. The cyanine fluorophores have absorbance and/or emission maxima in the near-infrared (NIR) and short-wave infrared (SWIR) wavelength ranges. Methods of making and using the cyanine fluorophores are also disclosed. The compounds are useful in fluorescence imaging, more particularly in cancer treatment.
    Type: Application
    Filed: August 23, 2019
    Publication date: June 17, 2021
    Applicant: The USA, as represented by the Secretary, Department of Health and Human Services
    Inventors: Martin J. Schnermann, Venu G. Bandi
  • Conformational restriction of cyanine fluorophores in far-red and near-IR range
    Patent number: 10994029
    Abstract: Conformationally restricted cyanine fluorophores, as well as methods of making and using the compounds, are described. The conformationally restricted cyanine fluorophores have a chemical structure according to Formula I, or a stereoisomer or pharmaceutically acceptable salt thereof: wherein A is and wherein each “*” designates an attachment point of A.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: May 4, 2021
    Assignee: The USA, as represented by the Secretary, Department of Health and Human Services
    Inventors: Martin J. Schnermann, Megan S. Michie
  • CONFORMATIONAL RESTRICTION OF CYANINE FLUOROPHORES IN FAR-RED AND NEAR-IR RANGE
    Publication number: 20200179536
    Abstract: Conformationally restricted cyanine fluorophores, as well as methods of making and using the compounds, are described. The conformationally restricted cyanine fluorophores have a chemical structure according to Formula I, or a stereoisomer or pharmaceutically acceptable salt thereof: wherein A is and wherein each “*” designates an attachment point of A.
    Type: Application
    Filed: August 24, 2018
    Publication date: June 11, 2020
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Martin J. Schnermann, Megan S. Michie
  • Hypoxia-inducible factor 1 (HIF-1) inhibitors
    Patent number: 10246463
    Abstract: Embodiments of small molecule inhibitors of hypoxia inducible factor 1 (HIF-1) and pharmaceutical compositions thereof are disclosed. The disclosed compounds suppress HIF-1 activity by inhibiting the interaction between the HIF-1 ? subunit and transcriptional co-activator protein p300. Embodiments of methods for making and using the small molecule inhibitors are also disclosed.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: April 2, 2019
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Kirk R. Gustafson, Martin J. Schnermann, Susanna T. S. Chan, Paresma R. Patel, William D. Figg, James B. McMahon
  • HYPOXIA-INDUCIBLE FACTOR 1 (HIF-1) INHIBITORS
    Publication number: 20180093995
    Abstract: Embodiments of small molecule inhibitors of hypoxia inducible factor 1 (HIF-1) and pharmaceutical compositions thereof are disclosed. The disclosed compounds suppress HIF-1 activity by inhibiting the interaction between the HIF-1 a subunit and transcriptional co-activator protein p300. Embodiments of methods for making and using the small molecule inhibitors are also disclosed.
    Type: Application
    Filed: April 6, 2016
    Publication date: April 5, 2018
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Kirk R. Gustafson, Martin J. Schnermann, Susanna T. S. Chan, Paresma R. Patel, William D. Figg, James B. McMahon