Abstract: Systems and methods for intelligently delivering fluid to a targeted tissue are described. The systems and methods may include directing a pump to distribute fluid to a targeted tissue and receiving one or more signals from an intracorporeal sensing system, where the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue. The systems and methods may also include determining whether the one or more sensed feedback parameters are within an acceptable range. If the one or more sensed feedback parameters are not within the acceptable range, the systems and methods may include determining an adjusted velocity for the plunger necessary to adjust the pressure of the fluid in the pump so that the one or more sensed feedback parameters move within the acceptable range and directing the pump to distribute the fluid at the adjusted velocity.

Abstract: A device for delivery of a radiopharmaceutical and, in some embodiments, delivery of a pharmaceutical agent are described herein. Various other components for delivery systems including tubing management systems, primer caps, diffusion chambers, radiation shields and syringe shields, and other devices and methods are also described.

Abstract: Sealing connectors for use in connecting tubing to tubing, tubing to needles or other implements, syringe to tubing, or syringe to needles or other implements that provide reduced turbulence and sharp transitions are described herein.

Abstract: Systems and methods for intelligently delivering fluid to a targeted tissue are described. The systems and methods may include directing a pump to distribute fluid to a targeted tissue and receiving one or more signals from an intracorporeal sensing system, where the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue. The systems and methods may also include determining whether the one or more sensed feedback parameters are within an acceptable range.

Abstract: A syringe for a fluid delivery system includes a pressure jacket having a distal end, a proximal end, and a throughbore therebetween. The syringe further includes a rolling diaphragm having a proximal end with an end wall for engaging a plunger, a distal end received within the throughbore of the pressure jacket. A sidewall extends between the proximal end and the distal end of the rolling diaphragm along a longitudinal axis. At least a portion of one of the sidewall and the end wall has non-uniform thickness. At least a portion of the sidewall is flexible and rolls upon itself when acted upon by the plunger such that an outer surface of the sidewall at a folding region is folded in a radially inward direction as the plunger is advanced from the proximal end to the distal end of the rolling diaphragm.

Abstract: Systems and methods for intelligently delivering fluid to a targeted tissue. The systems and methods may include directing a pump to distribute fluid to a targeted tissue and receiving one or more signals from an intracorporeal sensing system, where the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue. The systems and methods may also include determining whether the one or more sensed feedback parameters are within an acceptable range. If the one or more sensed feedback parameters are not within the acceptable range, the systems and methods may include determining an adjusted velocity for the plunger necessary to adjust the pressure of the fluid in the pump so that the one or more sensed feedback parameters move within the acceptable range and directing the pump to distribute the fluid at the adjusted velocity.

Abstract: A device for delivery of a radiopharmaceutical and, in some embodiments, delivery of a pharmaceutical agent are described herein. Various other components for delivery systems including tubing management systems, primer caps, diffusion chambers, radiation shields and syringe shields, and other devices and methods are also described.

Abstract: A device for delivery of a radiopharmaceutical and delivery of a pharmaceutical agent are described. Various other components for delivery systems including tubing management systems, primer caps, diffusion chambers, radiation shields and syringe shields, needle handles, and other devices and methods are also described. Specifically, needle handles having a needle handle body attachable to a portion of a needle, and one or more wings or fins which are grasped by a user are described. The needle handle may be separated from the needle after insertion of the needle into a subject, and/or may provide access to a portion of tubing extending from the needle.

Abstract: A device for delivery of a radiopharmaceutical and delivery of a pharmaceutical agent are described. Various other components for delivery systems including tubing management systems, primer caps, diffusion chambers, radiation shields and syringe shields, needle handles, and other devices and methods are also described. Specifically, needle handles having a needle handle body attachable to a portion of a needle, and one or more wings or fins which are grasped by a user are described. The needle handle may be separated from the needle after insertion of the needle into a subject, and/or may provide access to a portion of tubing extending from the needle.

Abstract: A system includes at least one pressurizing mechanism, a fluid path adapted to be placed in operative connection with the pressurizing mechanism to deliver an injectate to a patient, wherein the injectate includes cells, a control system operably associated with the at least one pressurizing mechanism; and at least one parameter generation system in operative connection with the control system. The parameter generation system includes an input system to receive data of a type of cells to be injected and is adapted to generate at least one parameter for the injection procedure at least in part on the basis of the data of the type of cells. The at least one parameter for the injection procedure may, for example, be a variable associated with the injectate, a variable associated with an injection protocol or a variable associated with at least one component of the fluid path.

Abstract: Systems and methods for intelligently delivering fluid to a targeted tissue. The systems and methods may include directing a pump to distribute fluid to a targeted tissue and receiving one or more signals from an intracorporeal sensing system, where the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue. The systems and methods may also include determining whether the one or more sensed feedback parameters are within an acceptable range. If the one or more sensed feedback parameters are not within the acceptable range, the systems and methods may include determining an adjusted velocity for the plunger necessary to adjust the pressure of the fluid in the pump so that the one or more sensed feedback parameters move within the acceptable range and directing the pump to distribute the fluid at the adjusted velocity.

Abstract: A configurable fluid delivery system and methods for its use are disclosed. The system may include one or more control units, fluid delivery units, fluid actuator units, and disposable units. Data sources and sensors on each of the delivery units, actuator units, and disposable units may provide data to the control unit, thereby identifying the components along with the manner in which they may be configured. The control unit may notify a user regarding the status of any one or more of the delivery, actuator, and disposable units to indicate their appropriateness for delivering a fluid according to one or more selected procedures and protocols. Also disclosed are methods by which the configurable fluid delivery unit may provide data to a user to assist the user in assembling and testing a particular fluid delivery configuration for a specific use.

Abstract: A fluid injection system for controlling at least one fluid delivery system is provided. The fluid injection system includes at least one computing device in communication with the at least one fluid delivery system. The at least one computing device is configured to: display, on or with at least one display device, at least one graphical user interface configured to facilitate a user selection of at least one injection protocol of a plurality of injection protocols; receive, from at least one user, at least one selected injection protocol from the plurality of injection protocols; retrieve, from at least one remote server computer, the at least one selected injection protocol; and control the at least one fluid delivery system based at least partially on the at least one selected injection protocol.

Abstract: A device for delivery of a radiopharmaceutical and, in some embodiments, delivery of a pharmaceutical agent are described herein. Various other components for delivery systems including tubing management systems, primer caps, diffusion chambers, radiation shields and syringe shields, and other devices and methods are also described.

Abstract: Sealing connectors for use in connecting tubing to tubing, tubing to needles or other implements, syringe to tubing, or syringe to needles or other implements that provide reduced turbulence and sharp transitions are described herein.

Abstract: An injector system for use in injecting a fluid into a patient includes a communication system adapted to receive data from at least a first sensor that measures a value first variable. The communication system is also adapted to receive data from a calibrated sensor that measures a value the first variable. The injector system further includes a calibration system adapted to calibrate output from the first sensor in response to output from the calibrated sensor. An injector for use in injecting a fluid into a patient, includes a first sensor that measures a value first variable, a communication port adapted to receive data from a calibrated sensor that measures the value the first variable, and a controller adapted to compare data from the calibrated sensor with data from the first sensor and to calibrate output from the first sensor. The devices, systems and methods of the present invention are applicable to systems other than injection systems.

Abstract: An injector for use in injecting a fluid in a medical injection procedure includes a drive having a motor to pressurize the fluid; a sensor to provide a measure of fluid pressure; and a pressure monitor in communication with the sensor and the drive to stop the motor using 4-quadrant control when the sensor communicates a measured pressure of at least a pressure hazard limit. The pressure monitor also limits power input to the motor to a power limit once the sensor communicates a measured pressure of at least a power limiting pressure. The power limiting pressure is below the pressure hazard limit.

Abstract: An injector for use in injecting a fluid in a medical injection procedure includes a drive having a motor to pressurize the fluid; a sensor to provide a measure of fluid pressure; and a pressure monitor in communication with the sensor and the drive to stop the motor using 4-quadrant control when the sensor communicates a measured pressure of at least a pressure hazard limit. The pressure monitor also limits power input to the motor to a power limit once the sensor communicates a measured pressure of at least a power limiting pressure. The power limiting pressure is below the pressure hazard limit.

Abstract: An injector for use in injecting a fluid in a medical injection procedure includes a drive having a motor to pressurize the fluid; a sensor to provide a measure of fluid pressure; and a pressure monitor in communication with the sensor and the drive to stop the motor using 4-quadrant control when the sensor communicates a measured pressure of at least a pressure hazard limit. The pressure monitor also limits power input to the motor to a power limit once the sensor communicates a measured pressure of at least a power limiting pressure. The power limiting pressure is below the pressure hazard limit.

Abstract: A portable excavator having a tube to point a supersonic gas stream at a buried object. The excavator includes a movable member disposed within the conduit to pulse gas passing through the conduit and a supersonic gas nozzle at the exit of the conduit. Compressed gas delivered to the conduit exits the nozzle in a pulsed manner at two to three Hz. The movable member includes a piston which blocks gas from flowing through the conduit by the biasing force of a spring. When the force to the pressure differential across the piston exceeds the biasing force, the piston moves and allows gas to flow through the conduit until the force from the pressure differential across the piston is less than the biasing force.