Patents by Inventor Martin James Wythes

Martin James Wythes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolidinyl methyl indole salt
    Patent number: 5994387
    Abstract: The fumarate salt of (R)-5-(methylaminosulphonylmethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-in dole, useful in the treatment of migraine.
    Type: Grant
    Filed: November 12, 1997
    Date of Patent: November 30, 1999
    Assignee: Pfizer Inc.
    Inventor: Martin James Wythes
  • Indole derivative for the treatment of migraine
    Patent number: 5945118
    Abstract: This invention relates to (R)-5-(aminosulphonylmethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole and its pharmaceutically acceptable salts. This compound is particularly useful in treating disorders arising from deficient serotonergic neurotransmission, especially migraine.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: August 31, 1999
    Assignee: Pfizer Inc
    Inventors: Martin James Wythes, Paul Morgan
  • Indole derivatives
    Patent number: 5747501
    Abstract: Compounds of the formula ##STR1## where W is ##STR2## n is 0, 1, or 2; m is 0, 1, 2, or 3: Y and G are each independently oxygen or sulfur; Z is --O--, --S--, --NH, or --CH.sub.2 ; R.sub.1 is hydrogen, C.sub.1 to C.sub.8 alkyl, substituted C.sub.1 to C.sub.8 alkyl substituted with one hydroxy, C.sub.3 to C.sub.8 alkenyl, C.sub.3 to C.sub.8 alkynyl, aryl, C.sub.1 to C.sub.3 alkylaryl, C.sub.1 to C.sub.3 alkylheteroaryl, or --Q--R.sub.4 ; R.sub.2 and R.sub.3 are each independently hydrogen, C.sub.1 to C.sub.6 alkyl, aryl, C.sub.1 to C.sub.3 alkylaryl, or C.sub.1 to C.sub.3 alkylheteroaryl; R.sub.4 is cyano, trifluoromethyl, --COR.sub.9, --CO.sub.2 R.sub.9, --CONR.sub.9 R.sub.10, --OR.sub.9, --SO.sub.2 NR.sub.9 R.sub.10, or --S(O).sub.q R.sub.9 ; R.sub.9 and R.sub.10 are each independently hydrogen, C.sub.1 to C.sub.8 alkyl, C.sub.1 to C.sub.3 alkylaryl, aryl, or R.sub.9 and R.sub.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: May 5, 1998
    Assignee: Pfizer, Inc.
    Inventors: John Eugene Macor, Martin James Wythes
  • Indole derivatives as 5-HT1-like agonists
    Patent number: 5639779
    Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R.sup.1 is a substituted alkylene; C.sub.3 -C.sub.7 cycloalkyl optionally substituted with HO; C.sub.3 -C.sub.6 alkenyl optionally substituted with aryl; C.sub.5 -C.sub.7 cycloalkenyl; or C.sub.3 -C.sub.6 alkynyl; R.sup.2 is H; halo; F.sub.3 C; NC; R.sup.8 R.sup.9 NOC; a substituted alkylene; R.sup.8 R.sup.9 NO.sub.2 S; R.sup.10 S(O).sub.m ; R.sup.12 CON(R.sup.11); R.sup.10 SO.sub.2 N(R.sup.11); R.sup.8 R.sup.9 NOCN(R.sup.11); R.sup.10 O.sub.2 CN(R.sup.11); R.sup.13 (CH.sub.2).sub.n CH.dbd.CH; or R.sup.7 O are selective 5-HT.sub.1 -like receptor agonists useful in the treatment of migraine, cluster headache, chronic paroxysmal hemicrania and headache associated with vascular disorders.
    Type: Grant
    Filed: October 6, 1994
    Date of Patent: June 17, 1997
    Assignee: Pfizer Inc.
    Inventors: Martin James Wythes, John Eugene Macor