Abstract: Compounds having the structure of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and A are as defined in the specification; pharmaceutical compositions comprising such compounds and salts; use of such compounds and salts to treat or prevent Menin-mediated conditions; kits comprising such compounds and salts; and methods for manufacturing such compounds and salts.

Abstract: A heating block including a heating block body which receives/guides a liquid medium, an electric heating element arranged in the cavity for heating the medium via electric current, a semiconductor switch for controlling the electric current flowing through the heating element to control a heating power of the heating element, and a closure piece for closing an opening in the heating block body to the cavity element. The semiconductor switch is electrically and thermally conductively connected to the closure piece via first connection terminal to electrically connect the first connection terminal to the heating element via the closure piece, and to thermally connect the first connection terminal to the medium via the closure piece. The semiconductor switch is directly connected to a control board by a second connection terminal so that the semiconductor switch is spatially arranged and mechanically connected directly between the control board and the connection piece.

Abstract: A heating block for use in a water heater for heating water, having a heating block body, in particular made of plastic, for forming a cavity for conducting the water and for receiving at least one heating element. The heating block body includes a first partial shell having a first sub-cavity and a second partial shell having a second sub-cavity. The first and the second partial shells are assembled in a joining region and form between them the cavity from the two sub-cavities. The joining region is not formed, at least partially, in a joining plane and/or the first and the second partial shells are welded together by the supply of heat via a medium, in particular, an essentially abrasion-free and/or vibration-free welding process, and/or the first partial cavity has a greater depth than the second partial cavity or vice versa.

Abstract: The present invention relates to a process for preparing single wall carbon nanotubes (SWCNT) having a diameter dSWCNT, which comprises (i) providing a precursor element which comprises a segment SSWCNT of the single wall carbon nanotube, the segment SSWCNT being made of at least one ring formed by ortho-fused benzene rings, and having a first end E1 which is open and a second end E2 which is opposite to the first end E1, (ii) growing the precursor element by vapour phase reaction with a carbon-source compound on the surface of a metal-containing catalyst, wherein the precursor element is in contact with the surface of the metal-containing catalyst via the open end E1 of the segment SSWCNT, and the metal-containing catalyst is in the form of particles having an average diameter dcat satisfying the following relation: dcat>2×dSWCNT or in the form of a continuous film.

Abstract: The invention relates to a process for applying solid layers (14) to an object (12) to be coated by means of at least one radiation source (2), in particular a laser radiation source, which comprises at least the step of removal of a sample (4) in the solid state in at least partially different sections (6) by means of at least one beam (8) emitted by the radiation source (2) to at least partly convert the sample (4) into a gaseous state (10) which deposits at least partially on the object (12) to be coated in order to form a solid layer (14), where at the same time the alignment of a trace of the emitted beam (8) is altered during the step of removal of the sample and the sample (4) is moved.

Abstract: A heating block including a heating block body which receives/guides a liquid medium, an electric heating element arranged in the cavity for heating the medium via electric current, a semiconductor switch for controlling the electric current flowing through the heating element to control a heating power of the heating element, and a closure piece for closing an opening in the heating block body to the cavity element. The semiconductor switch is electrically and thermally conductively connected to the closure piece via first connection terminal to electrically connect the first connection terminal to the heating element via the closure piece, and to thermally connect the first connection terminal to the medium via the closure piece. The semiconductor switch is directly connected to a control board by a second connection terminal so that the semiconductor switch is spatially arranged and mechanically connected directly between the control board and the connection piece.

Abstract: A heating block for use in a water heater for heating water, having a heating block body, in particular made of plastic, for forming a cavity for conducting the water and for receiving at least one heating element. The heating block body includes a first partial shell having a first sub-cavity and a second partial shell having a second sub-cavity. The first and the second partial shells are assembled in a joining region and form between them the cavity from the two sub-cavities. The joining region is not formed, at least partially, in a joining plane and/or the first and the second partial shells are welded together by the supply of heat via a medium, in particular, an essentially abrasion-free and/or vibration-free welding process, and/or the first partial cavity has a greater depth than the second partial cavity or vice versa.

Abstract: The present invention relates to a one-pot synthesis for an SiBNC preceramic polymer.

Abstract: The invention relates to a process for applying solid layers (14) to an object (12) to be coated by means of at least one radiation source (2), in particular a laser radiation source, which comprises at least the step of removal of a sample (4) in the solid state in at least partially different sections (6) by means of at least one beam (8) emitted by the radiation source (2) to at least partly convert the sample (4) into a gaseous state (10) which deposits at least partially on the object (12) to be coated in order to form a solid layer (14), where at the same time the alignment of a trace of the emitted beam (8) is altered during the step of removal of the sample and the sample (4) is moved.

Abstract: This invention relates to a new method for the production of nitride-based phosphors, in particular, of phosphors containing rare earth elements. The phosphors can be used, for example, in light sources, especially in Light Emitting Devices (LEDs).

Abstract: The invention relates to a new class of luminescent substances (phosphorous) based on an universally dopable matrix made of an amorphous, at the most partially crystalline network of the elements P, Si, B, Al and N, preferably the composition Si3B3N7. Optical excitation and emission can be varied in this system over the entire practically relevant field by incorporation of any cationic activators, alone or in combination, but also by incorporation of oxygen as anionic component. This opens up the entire spectrum of use of luminescent substances, such as illumination systems or electronic screens.

Abstract: The present invention relates to novel methods for the salt-free polymerization of borosilylamines, which comprise the structural feature Si—N—B and borosilyl hydrocarbons, which comprise the structural feature Si—X—B, wherein X may be a methylene group or a hydrocarbon chain CxHy or a cyclic hydrocarbon unit, by reaction thereof with disilazanes R3Si—NR—SiR3.

Abstract: The invention relates to a light source comprising a primary radiation source and a luminescent substance, and to a method for producing this light source. The invention relates, in particular, to a method for producing an electric light source using one or more luminescent substances emitting in the visible spectrum range, and at least one primary source emitting preferably in the UV range, and which is preferably, but not exclusively, an LED.

Abstract: The present invention relates to methods for producing inorganic resins, comprising the polymerisation of at least one hydrogen-free, inorganic isocyanate which may be converted into a pure, hydrogen-free polymer by CO2 abstraction, to resins which are produced by this method, and to the use of such resins for producing coatings.

Abstract: The present invention relates to novel processes for preparing borylsilylamines, novel amines, novel borosilazane compounds, novel oligoborosilazane or polyborosilazane compounds which have the structural feature Si—N—B, ceramic material and methods of producing and using them.

Abstract: A charge air cooler for an internal combustion engine is disclosed. The charge air cooler includes at least one connecting piece for connection to at least one cooling circuit configured to conduct coolant. The charge air cooler includes at least one coolant pump for circulating the coolant. The at least one coolant pump is integrated in at least one flow path within the charge air cooler.

Abstract: The present invention relates to a method for producing hydrogen-free carbon nitrides, in particular carbon nitrides of the stoichiometry C3N4. The carbon nitrides are synthesized using hydrogen-free reactants, namely inorganic isocyanates that release only CO2 when thermally treated. In particular, a way of cheaply and efficiently providing carbonitrides, advantageously in the form of powders or coatings, is proposed.

Abstract: This invention relates to a new method for the production of nitride-based phosphors, in particular, of phosphors containing rare earth elements. The phosphors can be used, for example, in light sources, especially in Light Emitting Devices (LEDs).

Abstract: The present invention relates to novel methods for the salt-free polymerisation of borosilylamines, which comprise the structural feature Si—N—B and borosilyl hydrocarbons, which comprise the structural feature Si—X—B, wherein X may be a methylene group or a hydrocarbon chain CxHy or a cyclic hydrocarbon unit, by reaction thereof with disilazanes R3Si—NR—SiR3.

Abstract: The present invention relates to novel processes for preparing borylsilylamines, novel amines, novel borosilazane compounds, novel oligoborosilazane or polyborosilazane compounds which have the structural feature Si—N—B, ceramic material and methods of producing and using them.