Abstract: The present invention relates to compounds that are inhibitors of the orexin-1 receptor. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with orexin-1 receptor activity.

Abstract: The present invention relates to compounds that are inhibitors of the orexin-1 receptor. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with orexin-1 receptor activity.

Abstract: A full aperture beverage end has a center panel, a countersink surrounding the center panel, a main score arranged in proximity to the countersink to define a removable aperture panel and a vent score. The beverage end is adapted for use with products that are pressurized to over 30 psi (200 kPa) when opened, and during opening the vent score is adapted to sever first, controlling the pressure differential between the external surface and internal surface of the center panel, thereby allowing the main score to tear in a controlled and reliable manner.

Abstract: The present invention relates to compounds that are inhibitors of the orexin-1 receptor. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with orexin-1 receptor activity.

Abstract: A full aperture beverage end has a center panel, a countersink surrounding the centre panel, a main score arranged in proximity to the countersink to define a removable aperture panel and a vent score. The beverage end is adapted for use with products that are pressurized to over 30 psi (200 kPa) when opened, and during opening the vent score is adapted to sever first, controlling the pressure differential between the external surface and internal surface of the centre panel, thereby allowing the main score to tear in a controlled and reliable manner.

Abstract: A full aperture beverage end has a center panel, a countersink surrounding the centre panel, a main score arranged in proximity to the countersink to define a removable aperture panel and a vent score. The beverage end is adapted for use with products that are pressurized to over 30 psi (200 kPa) when opened, and during opening the vent score is adapted to sever first, controlling the pressure differential between the external surface and internal surface of the centre panel, thereby allowing the main score to tear in a controlled and reliable manner.

Abstract: A full aperture beverage end has a center panel, a countersink surrounding the center panel, a main score arranged in proximity to the countersink to define a removable aperture panel and a vent score. The beverage end is adapted for use with products that are pressurized to over 30 psi (200 kPa) when opened, and during opening the vent score is adapted to sever first, controlling the pressure differential between the external surface and internal surface of the center panel, thereby allowing the main score to tear in a controlled and reliable manner.

Abstract: A container (100) comprising: a substantially circular opening (406); and a radially projecting curled lip (408) extending around the opening for securing a substantially circular cap over the opening by way of a snap-fit, wherein the radial dimension of the curled lip varies around the opening.

Abstract: The present invention concerns a full aperture beverage end (14) having a centre panel (30), a countersink (22) surrounding the centre panel (30), a main score (50) arranged in proximity to the countersink (22) to define a removeable aperture panel (54) and a vent score (46). The beverage end (14) is adapted for use with products that are pressurised to over 30 psi (207 kPa) when opened, and during opening the vent score (46) is adapted to sever first, controlling the pressure differential between the external surface and internal surface of the centre panel (30), thereby allowing the main score (50) to tear in a controlled and reliable manner.

Abstract: A full aperture beverage end has a center panel, a countersink surrounding the centre panel, a main score arranged in proximity to the countersink to define a removable aperture panel and a vent score. The beverage end is adapted for use with products that are pressurized to over 30 psi (200 kPa) when opened, and during opening the vent score is adapted to sever first, controlling the pressure differential between the external surface and internal surface of the centre panel, thereby allowing the main score to tear in a controlled and reliable manner.

Abstract: A can end having a countersink bead, an inclined chuck wall and a strong seam, resists distortion from its circular profile when subjected to thermal processing or when packaging carbonated beverages. This high hoop strength affects the manner in which the can end ultimately fails when placed under extreme abuse conditions, even if buckle pressure performance is within industry specified standards. The can end of the invention has control features introduced which control the failure mode whilst maintaining specified buckle pressure performance. In one embodiment, the control feature comprises expansion of the countersink bead to act as a trigger for local peaking, together with a groove in the chuck wall which prevents the peaking force from being concentrated at a single point which could result in leaking by the production of a pin hole.

Abstract: A closure for a container, which has a self-closing valve having a cup-shaped valve head (32) with a dispensing aperture defined therein. In response to increased pressure in the container, the head of the self-closing valve to flatten and partially invert, thereby opening the dispensing aperture (6). The closure (1) includes an energizing ring (5) arrange surrounding the valve head (32) and adapted to restrict the radial expansion thereof. The position and design of the energizing ring (5) relative to the valve head (32) may be adjusted to affect the performance of the valve allowing a single valve design to be used for a number of different applications. Alternatively the energizing ring (5) may be used to improve the performance of a particular design of valve.

Abstract: A can end having a countersink bead, an inclined chuck wall and a strong seam, resists distortion from its circular profile when subjected to thermal processing or when packaging carbonated beverages. This high hoop strength affects the manner in which the can end ultimately fails when placed under extreme abuse conditions, even if buckle pressure performance is within industry specified standards. The can end of the invention has control features introduced which control the failure mode whilst maintaining specified buckle pressure performance. In one embodiment, the control feature comprises expansion of the countersink bead to act as a trigger for local peaking, together with a groove in the chuck wall which prevents the peaking force from being concentrated at a single point which could result in leaking by the production of a pin hole.

Abstract: A dispensing pump for liquid or pasty products comprising a housing (2), a piston (6) arranged to move telescopically within the housing between rest and activated positions and a plastics spring (9) arranged to return the piston from its activated to its rest position. The plastics spring has a folded, concertina configuration to provide the required return force for the piston. The spring also has end plates (91, 92), which can be adapted increased functionality. The whole pump may be moulded from a plastics material and has few component parts.

Abstract: A closure (1) for a container, which has a self-closing valve (3) having a cup-shaped valve head (32) with a dispensing aperture (6) defined therein. In response to increased pressure in the container, the head (32) of the self-closing valve (3) is designed to flatten and partially invert, thereby opening the dispensing aperture (6). The closure (1) includes an energising ring (5) arranged surrounding the valve head (32) and adapted to restrict the radial expansion thereof. The position and design of the energising ring (5) relative to the valve head (32) may be adjusted to affect the performance of the valve allowing a single valve design to be used for a number of different applications. Alternatively the energising ring (5) may be used to improve the performance of a particular design of valve.

Abstract: A dispensing pump for liquid or pasty products comprising a housing (2), a piston (6) arranged to move telescopically within the housing between rest and activated positions and a plastics spring (9) arranged to return the piston from its activated to its rest position. The plastics spring has a folded, concertina configuration to provide the required return force for the piston. The spring also has end plates (91, 92), which can be adapted increased functionality. The whole pump may be moulded from a plastics material and has few component parts.