Abstract: Heptamethine cyanines for use as fluorescent markers of the biliary system are disclosed. Certain heptamethine cyanines exhibit biliary system specificity and methods for in vivo visualization of a biliary system of a subject are provided. The methods may be for diagnostic purposes and/or for visualization of biliary systems during surgery.

Abstract: Methods and systems for improving resource content mapping for an electronic learning system. The methods can include: receiving, by the electronic learning system, a resource for satisfying at least one learning objective of the one or more learning objectives, the resource comprising a content having a content data convertible into a text data and one or more resource property fields defining at least one characteristic of the resource; sectioning the content data into one or more content portions based on an analysis of at least one of the content data and the one or more resource property fields; and assigning at least one content portion of the one or more content portions to at least one learning objective.

Abstract: A manufacturing system includes a stator base, a plurality of movers, one or more end effectors, and a controller. The stator base has a planar stator surface covering an array of electrical coils configured to generate an electromagnetic field. The movers each contain multiple permanent magnets configured to cause the movers to levitate and move relative to the stator surface in response to the electromagnetic field. The end effectors are coupled to the movers, and each end effector perform one or more functions in relation to a material sheet. The controller activates the electrical coils in a manner causing independent, coordinated movement of the movers over the stator surface, and causing the end effectors to engage with and operate on the material sheet.

Abstract: This specification describes systems and methods for using Zero Echo Time (ZTE) magnetic resonance imaging (MRI) sequences for applications to functional MRI (fMRI). In some examples, a system for functional magnetic resonance imaging includes a magnetic resonance imaging (MRI) scanner and a control console implemented on at least one processor. The control console is configured for executing, using the MRI scanner, a zero echo time (ZTE) pulse sequence; acquiring, using the MRI scanner, magnetic resonance data in response to the ZTE pulse sequence; and constructing at least one MRI image using the magnetic resonance data and measuring tissue oxygenation (PtO2)-related T1 changes as a proxy of neural activity changes of a subject using the at least one MRI image.

Abstract: The present invention relates to a method for preparing 2-[2-(2-chlorothiazol-5-yl)-2- hydroxy-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof or enantiomerically enriched forms thereof, to 2-[2-(2-chlorothiazol-5-yl)-2-hydroxy-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof or enantiomerically enriched forms thereof, and to the use thereof as intermediate in the preparation of 2,3-dihydrothiazolo[3,2-a]pyrimidinium compounds, specifically of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo [3,2-a]pyrimidin-4-ium-5-olate and enantiomerically enriched forms thereof.

Abstract: A monitoring system that is configured to monitor a property is disclosed. The monitoring system includes a sensor that is configured to generate sensor data that indicates an attribute of the property; a floor sensor that is configured to generate floor sensor data that indicates an amount of pressure applied to a portion of a floor of the property; and a monitor control unit. The monitor control unit is configured to receive, from the sensor, the sensor data; receive, from the floor sensor, the floor sensor data; analyze the sensor data and the floor sensor data; and based on analyzing the sensor data and the floor sensor data, perform a monitoring system action.

Abstract: Various embodiments of a vortex hybrid motor are described herein. In some embodiments, the vortex hybrid motor may include a housing with a solid propellant positioned within the housing, and an injector ring positioned at a proximal end of the housing. The injector ring can include a plurality of angled injector units each including a first injector and a second injector angled towards an impingement point. A first fluid stream of a liquid propellant dispensed from the first injector can collide with a second fluid stream of the liquid propellant dispensed from the second injector to atomize the liquid propellant and form a spray fan formation. At least one of the first injector and the second injector can be positioned at an injection angle relative to the sidewall to create a swirl flow of the atomized injector fluid.

Abstract: Methods, systems, and devices for techniques for generating access line voltages are described. A system may use a first voltage supply and a second voltage supply that is configured to supply a lower voltage than the first voltage supply. The system may activate a first circuit to couple a node with the first voltage supply so that a first voltage develops on the node from the first voltage supply. The system may activate a second circuit to couple the node with the second voltage supply so that a second voltage that is lower than the first voltage develops on the node from the second voltage supply.

Abstract: In one aspect, the subject invention is directed to a method of preparing a combinatorial drug delivery device based on a predetermined selection of drug components. The method includes: preparing a plurality of containers, each accommodating one of the selected drug components; coupling the containers to a common outlet so that the drug components may be extracted from the containers and dispensed through the common outlet; and, applying negative pressure to extract the drug components from the containers and urge the drug components towards the common outlet.

Abstract: The present invention relates to a method for preparing an enantiomerically enriched form of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-4-ium-5-olate.

Abstract: An optical device includes a first optically dimmable switch for providing a first transmittance while the first optically dimmable switch is in a first state and providing a second transmittance distinct from the first transmittance while the first optically dimmable switch is in a second state distinct from the first state. The optical device also includes a dynamic heat source thermally coupled with the first optically dimmable switch. The dynamic heat source is at a first temperature at a first time and is at a second temperature distinct from the first temperature at a second time mutually exclusive from the first time. The optical device may operate as an optical dimming device, which may be used in head-mounted display devices or as dimmable windows or shutters.

Abstract: The present invention relates to a method for preparing 2-[2-(2-chlorothiazol-5-yl)-2-oxo-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof, to 2-[2-(2-chlorothiazol-5-yl)-2-oxo-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof and to its use as intermediate in the preparation of 2,3-dihydrotheiazolo [3,2-a]pyrimidinium compounds, and specifically of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo [3,2-a]pyrimidin-4-ium-5-olate and enantiomerically enriched forms thereof.

Abstract: A converter module is described which handles memory requests issued by a cache (e.g. an on-chip cache), where these memory requests include memory addresses defined within a virtual memory space. The converter module receives these requests, issues each request with a transaction identifier and uses that identifier to track the status of the memory request. The converter module sends requests for address translation to a memory management unit and where there the translation is not available in the memory management unit receives further memory requests from the memory management unit. The memory requests are issued to a memory via a bus and the transaction identifier for a request is freed once the response has been received from the memory. When issuing memory requests onto the bus, memory requests received from the memory management unit may be prioritized over those received from the cache.

Abstract: A novel high efficiency image projection system includes a beam-steering modulator, an amplitude modulator, and a controller. In a particular embodiment the controller generates beam-steering drive values from image data and uses the beam-steering drive values to drive the beam-steering modulator. Additionally, the controller utilizes the beam-steering drive values to generate a lightfield simulation of a lightfield projected onto the amplitude modulator by the beam-steering modulator. The controller utilizes the lightfield simulation to generate amplitude drive values for driving the amplitude modulator in order to project a high quality version of the image described by the image data.

Abstract: The present disclosure relates generally to methods of treating T-cell lymphomas with combination therapies.

Abstract: A personal care device including at least one sensor (28) configured to obtain sensor data including information about a user; a controller (30) having a feature extraction module (230) and a classifier (240), the feature extraction module configured to extract one or more features from the obtained sensor data, the classifier configured to determine a status of a user based on the extracted one or more features; and a personal care device (10) configured to provide a personal care function and receive one or more control signals to adjust the personal care function based on a determined status of at least a portion of the user's body.

Abstract: This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and Y have the meanings as defined in the description in the presence of a catalyst comprising at least one m-valent metal cation Mm+ wherein the metal M is selected from Scandium (Sc), Yttrium (Y), Lanthanum (La), Cerium (Ce), Praseodymium (Pr), Neodymium (Nd), Promethium (Pm), Samarium (Sm), Europium (Eu), Gadolinium 15 (Gd), Terbium (Tb), Dysprosium (Dy), Holmium (Ho), Erbium (Er), Thulium (Tm), Ytterbium (Yb), Lutetium (Lu), Gallium (Ga) and Indium (In), and m is an integer of 1, 2 or 3, and a chiral ligand of the formula (IV) wherein R10a, R10b, R10c, R10d, R10a?, R10b?, R10c?, R10d?, Z and Z? have the meanings as defined in the description.

Abstract: An exhaust conduit for neutralizing condensate from high efficiency gas storage water heaters is provided. The exhaust conduit includes an inlet configured to be coupled to an exhaust outlet of the heater, an outlet configured to be coupled to an exhaust vent, and a condensate chamber having an interior in fluidic communication with the inlet and the outlet. The condensate chamber has a lower portion configured to receive a neutralizer and an upper portion having a service port configured to provide access to the lower portion of the condensate chamber. The condensate chamber further includes a fluid outlet for draining the neutralized condensate via a drain line. The exhaust conduit has one or more ridges disposed in the chamber that are arranged to define a channel for directing condensate from the inlet across the neutralizer toward the fluid outlet.

Abstract: A coherency manager for receiving snoop requests addressed in a physical address space, the snoop requests relating to a cache memory addressable using a virtual address space, the cache memory having a plurality of coherent cachelines, the coherency manager comprising: a reverse translation module configured to maintain a mapping from physical addresses to virtual addresses for each coherent cacheline held in the cache memory; and a snoop processor configured to: receive a snoop request relating to a physical address; in response to the received snoop request, determine whether the physical address is mapped to a virtual address in the reverse translation module; and process the snoop request in dependence on that determination.

Abstract: In one aspect, a system is provided of verifying the accuracy of a plurality of serially-connected drug modules of a combinatorial drug delivery device, each of the drug modules including a drug reservoir, the system including: a machine-readable code located on each of the drug modules; application software configured to generate an activation code based on the machine-readable codes and the sequence of the machine-readable codes; a flow controller on the drug delivery device which is selectively actuatable to a use state to permit flow of drug from the drug delivery device; and, a control unit on the drug delivery device having a computing processing unit configured to compare the activation code with an authentication code, and, wherein, if the authentication code matches the activation code, the computing processing unit causes actuation of the flow controller to permit flow of the drug from the drug delivery device.