Abstract: We disclose a pharmaceutical composition adapted for oral delivery comprising native testosterone; a treatment regimen comprising administration of the composition(s); and methods and uses for the treatment of hormone related conditions such as hypogonadism in human male, female and transgender subjects.

Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

Abstract: A method for estimating a rate of penetration while drilling a subterranean wellbore includes estimating a first rate of penetration while drilling using a first measurement method, estimating a second rate of penetration while drilling using a second measurement method, and combining the first and second rates of penetration to obtain a combined rate of penetration of drilling.

Abstract: The present invention relates to boron containing compounds of Formula (IA): that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.

Abstract: In the disclosed systems and methods for competitive scene completion, in conjunction with a scene completion challenge, an image of an initial scene and a plurality of markers are displayed. For each user marker selection, virtual furnishing units corresponding to the unit type are displayed. User unit selection results in display of a three-dimensional graphic of the selected virtual furnishing unit at the corresponding coordinates within the scene, thereby creating an augmented scene that comprises the initial scene with three-dimensional graphics of selected virtual furnishing units. The augmented scene is submitted to a remote server. The user is provided with a reward that consists of credits. Responsive to user selection to access the store, a user interface for the store is displayed within the application. Visual representations of tangible products are displayed. The credits are configured for use towards purchase of the tangible products.

Abstract: A method may comprise positioning a downhole fluid sampling tool into a wellbore, performing a pressure test operation within the wellbore, performing a pumpout operation within the wellbore, identifying when a clean fluid sample may be taken by the downhole fluid sampling tool from at least the pressure test operation and the pumpout operation, and acquiring the clean fluid sample from the wellbore. A system may comprise a downhole fluid sampling tool and an information handling machine. The downhole fluid sampling tool may further comprise one or more probes attached to the downhole fluid sampling tool, one or more stabilizers attached to the downhole fluid sampling tool, and a sensor placed in the downhole fluid sampling tool configured to measure drilling fluid filtrate.

Abstract: This present disclosure seals the light propagation path in an optical interconnection element from external contaminants. The optical interconnection element includes a reflective surface, which can also be sealed from external contaminants Additional novel concepts include all enclosed sealed regions of the optical interconnection element being fluidly connected and making the final seal of the optical interconnection element with a thin plate, which can bend reducing the pressure differential between the ambient environment and the sealed internal volume of the optical interconnection element.

Abstract: The invention provides methods and compositions for breeding pepper (Capsicum sp. such as Capsicum annuum) lines, including isogenic and nearly isogenic lines, displaying one or more mature fruit color(s) of interest. Predictive genetic markers and associated sequences and primers, associated with phenotypic diversity at the Ccs locus encoding Capsanthin-Capsorubin Synthase, and the Ze locus encoding Zeaxanthin Epoxidase are also provided, as well as methods for breeding pepper lines. Further provided are pepper plants, and plant parts including seeds, seed mixtures, fruit, and packaged fruit, which display mature fruit color(s) of interest.

Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

Abstract: A computer includes a processor and a memory storing instructions executable by the processor to determine a predicted classification related to a road segment; upon a vehicle including the computer traveling over the road segment, determine an actual classification related to the road segment; in response to the actual classification failing to match the predicted classification, transmit a notification to a server remote from the vehicle; and upon receiving an instruction responsive to the notification, transmit vehicle data related to the road segment to the server.

Abstract: A system and method for providing power to moving elements on a conveyor system while the moving elements are moving. An accessory for mounting on one or more of the moving elements, which receives power from the system. Various accessories for using the power provided. In one case, the accessory is a rotary gripper that includes a body; a gripper motor; a rotation motor; and a plurality of grippers, wherein the gripper motor is mechanically connected with and configured to open and close the plurality of grippers, the rotation motor is mechanically connected with and configured to rotate the plurality of grippers. Other accessories include a gripper, a vacuum system, a heater, and a cooler.

Abstract: A computer includes a processor and a memory storing instructions executable by the processor to generate an operation parameter histogram for each of a plurality of vehicle operation parameters, operate a test vehicle according to the operation parameter histograms, input each operation parameter histogram and a plurality of test vehicle environment data to a machine learning program, output from the machine learning program a classification for each operation parameter histogram from the machine learning program, input the classifications to a predictive damage model of a three-dimensional schematic of a vehicle component, and adjust one of a size or a shape of the three-dimensional schematic based the output of the predictive damage model. The operation parameter histograms are based on collected data about operation of a plurality of vehicles. Each operation parameter histogram includes an array of elements.

Abstract: The present invention relates to novel compounds and method for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and cancer. Compounds of the invention include compounds having the formula (II) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R8, R9, R10, R12, Z, Y and m are as defined herein.

Abstract: A high performing low viscosity tire sealant includes about 15% to about 75% by weight of a biobased aliphatic diol, about 5% to about 50% by weight natural rubber latex, and about 2% to about 50% by weight synthetic rubber latex. The tire sealant exhibits excellent performance at temperatures of ?40 degrees Celsius and lower.

Abstract: An apparatus and method are provided for speculatively vectorising program code. The apparatus includes processing circuitry for executing program code, the program code including an identified code region comprising at least a plurality of speculative vector memory access instructions. Execution of each speculative vector memory access instruction is employed to perform speculative vectorisation of a series of scalar memory access operations using a plurality of lanes of processing. Tracking storage is used to maintain, for each speculative vector memory access instruction, tracking information providing an indication of a memory address being accessed within each lane. Checking circuitry then references the tracking information during execution of the identified code region by the processing circuitry, in order to detect any inter lane memory hazard resulting from the execution of the plurality of speculative vector memory access instructions.

Abstract: The present invention relates to novel compounds and method for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and cancer. Compounds of the invention include compounds having the formula (II) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R8, R9, R10, Z, Y and m are as defined herein.

Abstract: In one aspect the invention provides a boat support frame loading and unloading apparatus configured to draw a boat on to and off a boat support frame. This boat support frame has a loading end and a terminal end opposite to the loading end. The apparatus provided includes at least one roller assembly mounted to the support frame adjacent to the loading end of the support frame, said at least one roller assembly incorporating at least one roller element. The apparatus also includes at least one drive mechanism configured to rotate one or more roller elements to draw a boat onto and off the support frame through the loading end of the support frame. The roller assembly also includes a hull contact surface formed by a flexible belt which has a circumference greater than the circumference of the said at least one roller element incorporated into the roller assembly.

Abstract: The present disclosure provides pepper plants exhibiting resistance to Phytophthora capsici. Such plants may comprise novel introgressed chromosomal regions associated with disease resistance. In certain aspects, compositions, including novel polymorphic markers and methods for producing, breeding, identifying, and selecting plants or germplasm with a disease resistance phenotype are provided.

Abstract: The invention provides methods and compositions for breeding pepper (Capsicum sp. such as Capsicum annuum) lines, including isogenic and nearly isogenic lines, displaying one or more mature fruit color(s) of interest. Predictive genetic markers and associated sequences and primers, associated with phenotypic diversity at the Ccs locus encoding Capsanthin-Capsorubin Synthase, and the Ze locus encoding Zeaxanthin Epoxidase are also provided, as well as methods for breeding pepper lines. Further provided are pepper plants, and plant parts including seeds, seed mixtures, fruit, and packaged fruit, which display mature fruit color(s) of interest.