Patents by Inventor Martin Knoch
Martin Knoch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240016885Abstract: The invention relates to cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection. In particular, the invention provides a cyclosporine liquid formulation for use as an aerosol for inhalation in a method of preventing or treating pulmonary chronic graft rejection in single lung transplanted patients. The formulation is preferably administered once or twice daily. The formulation may be aerosolized with a nebulizer that comprises features for monitoring the time, date and duration of inhalation by the patient, in order to monitor patient adherence. The formulation according to the invention may be combined with standard immunosuppressants and corticosteroids.Type: ApplicationFiled: July 17, 2023Publication date: January 18, 2024Applicant: BREATH THERAPEUTICS GMBHInventors: Martin KNOCH, Oliver DENK
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Patent number: 11744872Abstract: The invention relates to cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection. In particular, the invention provides a cyclosporine liquid formulation for use as an aerosol for inhalation in a method of preventing or treating pulmonary chronic graft rejection in single lung transplanted patients. The formulation is preferably administered once or twice daily. The formulation may be aerosolized with a nebulizer that comprises features for monitoring the time, date and duration of inhalation by the patient, in order to monitor patient adherence. The formulation according to the invention may be combined with standard immunosuppressants and corticosteroids.Type: GrantFiled: October 30, 2020Date of Patent: September 5, 2023Assignee: BREATH THERAPEUTICS GMBHInventors: Martin Knoch, Oliver Denk
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Publication number: 20230119086Abstract: The invention relates to an aerosol delivery device comprising an aerosol generator for generating an aerosol in the aerosol delivery device, a sensor configured to detect a use of the aerosol delivery device for aerosol treatment, and a controller configured to deactivate the aerosol generator if no use of the aerosol delivery device for aerosol treatment is detected by the sensor. Further, the invention relates to a method for operating an aerosol delivery device, comprising the steps of operating an aerosol generator for generating an aerosol in the aerosol delivery device, detecting a use of the aerosol delivery device for aerosol treatment by means of a sensor, and deactivating the aerosol generator by means of a controller if no use of the aerosol delivery device for aerosol treatment is detected by the sensor.Type: ApplicationFiled: December 15, 2022Publication date: April 20, 2023Applicant: PARI Pharma GmbHInventor: Martin Knoch
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Patent number: 11547822Abstract: The invention relates to an aerosol delivery device (10) comprising an aerosol generator (3) for generating an aerosol in the aerosol delivery device (10), a sensor (5) configured to detect a use of the aerosol delivery device (10) for aerosol treatment, and a controller (7) configured to deactivate the aerosol generator (3) if no use of the aerosol delivery device (10) for aerosol treatment is detected by the sensor (5). Further, the invention relates to a method for operating an aerosol delivery device (10), comprising the steps of operating an aerosol generator (3) for generating an aerosol in the aerosol delivery device (10), detecting a use of the aerosol delivery device (10) for aerosol treatment by means of a sensor (5), and deactivating the aerosol generator (3) by means of a controller (7) if no use of the aerosol delivery device (10) for aerosol treatment is detected by the sensor (5).Type: GrantFiled: December 17, 2015Date of Patent: January 10, 2023Assignee: PARI Pharma GmbHInventor: Martin Knoch
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Publication number: 20220118198Abstract: The present disclosure relates to a mouthpiece (40) for delivering an aerosol supplied by a nebulizer (100) to a user, the mouthpiece (40) comprising a body (46) defining a fluid path (47) from an inlet port (41) connectable to the nebulizer (100) to an inhalation opening (42) to be received in the mouth of a user and a filter (30). The filter (30) has a filter base (31) in fluid communication with the fluid path (47), a filter top (33) detachably connected to the filter base (31) and a filter material (32) provided between the filter base (31) and the filter top (33). The filter top (33) has an exhalation opening (36) cooperating with a one-way valve (39) allowing exhaustion of fluid from the fluid path (47) through the filter material (32) to the outside of the mouthpiece upon exhalation of a patient through the inhalation opening (42). The body (46) and the filter base (31) are an integrated one-piece unit so as to provide for an easy to handle and comfortable mouthpiece (40).Type: ApplicationFiled: December 3, 2019Publication date: April 21, 2022Applicant: PARI Pharma GmbHInventors: Martin Knoch, Thomas Gallem, Mihaela Kaufmann
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Publication number: 20210046150Abstract: The invention relates to cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection. In particular, the invention provides a cyclosporine liquid formulation for use as an aerosol for inhalation in a method of preventing or treating pulmonary chronic graft rejection in single lung transplanted patients. The formulation is preferably administered once or twice daily. The formulation may be aerosolized with a nebulizer that comprises features for monitoring the time, date and duration of inhalation by the patient, in order to monitor patient adherence. The formulation according to the invention may be combined with standard immunosuppressants and corticosteroids.Type: ApplicationFiled: October 30, 2020Publication date: February 18, 2021Applicant: BREATH THERAPEUTICS GMBHInventors: Martin KNOCH, Oliver DENK
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Patent number: 10857198Abstract: The invention relates to cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection. In particular, the invention provides a cyclosporine liquid formulation for use as an aerosol for inhalation in a method of preventing or treating pulmonarychronic graft rejection in single lung transplanted patients. The formulation is preferably administered once or twice daily. The formulation may be aerosolized with a nebulizer that comprises features for monitoring the time, date and duration of inhalation by the patient, in order to monitor patient adherence. The formulation according to the invention may be combined with standard immunosuppressants and corticosteroids.Type: GrantFiled: March 15, 2016Date of Patent: December 8, 2020Assignee: BREATH THERAPEUTICS GMBHInventors: Martin Knoch, Oliver Denk
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Publication number: 20180042988Abstract: The invention relates to cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection. In particular, the invention provides a cyclosporine liquid formulation for use as an aerosol for inhalation in a method of preventing or treating pulmonarychronic graft rejection in single lung transplanted patients. The formulation is preferably administered once or twice daily. The formulation may be aerosolized with a nebulizer that comprises features for monitoring the time, date and duration of inhalation by the patient, in order to monitor patient adherence. The formulation according to the invention may be combined with standard immunosuppressants and corticosteroids.Type: ApplicationFiled: March 15, 2016Publication date: February 15, 2018Applicant: PARI Pharma GmbHInventor: Martin Knoch
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Publication number: 20170368282Abstract: The invention relates to an aerosol delivery device (10) comprising an aerosol generator (3) for generating an aerosol in the aerosol delivery device (10), a sensor (5) configured to detect a use of the aerosol delivery device (10) for aerosol treatment, and a controller (7) configured to deactivate the aerosol generator (3) if no use of the aerosol delivery device (10) for aerosol treatment is detected by the sensor (5). Further, the invention relates to a method for operating an aerosol delivery device (10), comprising the steps of operating an aerosol generator (3) for generating an aerosol in the aerosol delivery device (10), detecting a use of the aerosol delivery device (10) for aerosol treatment by means of a sensor (5), and deactivating the aerosol generator (3) by means of a controller (7) if no use of the aerosol delivery device (10) for aerosol treatment is detected by the sensor (5).Type: ApplicationFiled: December 17, 2015Publication date: December 28, 2017Applicant: PARI Pharma GmbHInventor: Martin Knoch
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Publication number: 20170232211Abstract: The invention relates to a fluid reservoir (2) for an aerosol generator (50), the fluid reservoir (2) comprising a fluid chamber (4) for receiving a fluid (6), an opening (8) for guiding the fluid (6) received in the fluid chamber (4) outside the fluid chamber (4), and a collar portion (10) surrounding the opening (8) and extending into the fluid chamber (4). A first portion (12) of the fluid chamber (4) extends along the length of the collar portion (10) in a height direction (H) of the fluid chamber (4), A second portion (14) of the fluid chamber (4) is arranged adjacent to the first portion (12) in the height direction (H) of the fluid chamber (4). A lateral extension of the first portion (12) in the directions perpendicular to the height direction (H) of the fluid chamber (4) is smaller than a lateral extension of the second portion (14) in the directions perpendicular to the height direction (H) of the fluid chamber (4).Type: ApplicationFiled: August 17, 2015Publication date: August 17, 2017Applicant: PARI Pharma GmbHInventors: Thomas Gallem, Uwe Hetzer, Martin Knoch, Michael Neuner
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Publication number: 20120211005Abstract: The present invention relates to a system that includes a pharmaceutical composition of a purified, stable, active alpha-1 proteinase inhibitor (API) in a form of a ready to use sterile solution and an inhalation nebulizer, and to methods of use thereof for treating pulmonary diseases.Type: ApplicationFiled: April 27, 2012Publication date: August 23, 2012Applicants: PARI PHARMA GMBH, KAMADA LTD.Inventors: Shabtai Bauer, Manfred Keller, Martin Knoch
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Publication number: 20100007260Abstract: A spark plug is described for Otto-cycle engines having a metallic spark plug body, having a center electrode, having a ceramic insulator, which is arranged between the center electrode and the body and is based on aluminium oxide, and having at least one earth electrode. The invention provides for the insulator to be composed of 0.01% by weight to 1% by weight of magnesium oxide, at most 0.3% by weight of natural and/or impurities, with the rest being aluminium oxide, and being formed by solid-phase sintering so that it is very largely free of glass phases.Type: ApplicationFiled: December 13, 2007Publication date: January 14, 2010Inventors: Werner Niessner, Martin Knoch, Klaus Stetter
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Publication number: 20090304604Abstract: The present invention relates to a system that includes a pharmaceutical composition of a purified, stable, active alpha-1 proteinase inhibitor (API) in a form of a ready to use sterile solution and an inhalation nebulizer, and to methods of use thereof for treating pulmonary diseases.Type: ApplicationFiled: February 8, 2007Publication date: December 10, 2009Applicants: KAMADA LTD., PARI PHARMA GMBHInventors: Shabtai Bauer, Manfred Keller, Martin Knoch
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Publication number: 20060054166Abstract: An inhalation nebulizer includes an aerosol generator that has a diaphragm vibrated by a vibration generator. The inhalation nebulizer includes a liquid storage container that is in fluid contact with the diaphragm. A liquid contained in the storage container is atomized into a mixing chamber through openings in the diaphragm and can subsequently be inhaled by a patient.Type: ApplicationFiled: November 7, 2005Publication date: March 16, 2006Applicant: Pari GmbH Spezialisten fur effektive InhalationInventors: Martin Knoch, Manfred Keller, Roland Stangl, Thomas Gallem, Rainer Liening-Ewert, Markus Urich
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Patent number: 6962151Abstract: An inhalation nebulizer (1) includes an aerosol generator (2) that has a diaphragm (22) vibrated by a vibration generator (23). The inhalation nebulizer (1) includes a liquid storage container (21) that is in fluid contact with the diaphragm (22). A liquid contained in the storage container (21) is atomized into a mixing chamber (3) through openings in the diaphragm and can subsequently be inhaled by a patient.Type: GrantFiled: October 27, 2000Date of Patent: November 8, 2005Assignee: Pari GmbH Spezialisten für effektive InhalationInventors: Martin Knoch, Manfred Keller, Roland Stangl, Thomas Gallem, Rainer Liening-Ewert, Markus Urich
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Patent number: 6679251Abstract: Metering aerosol dispensing device comprising an aerosol container (23); a nozzle (31, 32) that is arranged in a nozzle body (30), whereby the aerosol is dispensed via said nozzle when the aerosol container (23) is pushed against the body (30) of the nozzle once the metering aerosol dispensing device is actuated; a meter (1, 2, 4) that counts the number of times that the metering aerosol dispensing device is actuated; and an actuating device (10) that enables the meter (1, 2, 3, 4) to move forward when the metering aerosol dispensing device is actuated. The invention is characterized in that the actuating device (10) is designed and arranged in the metering aerosol dispensing device in such a way that the body (30) of the nozzle is accomodated in the interior of the actuating device (10) and the nozzle (31) is released in order to produce aerosol in an unrestricted manner.Type: GrantFiled: August 10, 2001Date of Patent: January 20, 2004Assignee: Pari GmbH Spezialisten fur effektive inhalationInventors: Thomas Gallem, Kevin Stapleton, Martin Knoch
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Patent number: D574384Type: GrantFiled: October 26, 2006Date of Patent: August 5, 2008Assignee: PARI Pharma GmbHInventor: Martin Knoch
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Patent number: D583775Type: GrantFiled: October 26, 2006Date of Patent: December 30, 2008Assignee: Pari Pharma GmbHInventor: Martin Knoch
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Patent number: D583928Type: GrantFiled: October 26, 2006Date of Patent: December 30, 2008Assignee: Pari Pharama GmbHInventor: Martin Knoch
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Patent number: D603410Type: GrantFiled: August 5, 2008Date of Patent: November 3, 2009Assignee: PARI PHARMA GmbH Spezialisten Für Effektive InhalationInventor: Martin Knoch