Abstract: Disclosed is a method and composition for treating a disease associated with target cells expressing CD138 in a multiple dose regimen. An immunoconjugate comprising an engineered targeting antibody targeting CD138 expressing cells and an effector molecule is administered in a multiple dose regimen. The multiple dose regimen comprises at least two doses and the aggregate dose administered within an active treatment cycle is an aggregate maximum tolerable dose (AMTD) or a fraction of the AMTD. The AMTD and/or said fraction exceeds the dose resulting in dose limiting toxicity (DLT) and/or exceeds the maximum tolerable dose (MTD) when the immunoconjugate is administered as a single dose, including as part of a multiple single dose regimen within said active treatment cycle.

Abstract: The invention relates to a method for reducing the number of leukocytes in blood through treating the blood in an arrangement of a plurality of fibers based on organic polymers, whereby the blood is channeled along the fibers and whereby the reduction in leukocytes from the blood occurs essentially through adsorption on the fibers, characterized in that the plurality of fibers based on organic polymers is fixed in a housing with an inlet arrangement and an outlet arrangement, and that the blood is channeled via the inlet arrangement into the housing, flows through the housing with the plurality of fibers made from organic polymers, and exits the housing via the outlet arrangement, that the arrangement of the fibers shows a high degree of order, that the blood flows along the external surface of the fibers, and that the fibers cause a generation of the complement activation product C5a in a concentration of at least 10 ?g per m2 of fiber surface.

Abstract: A device for reducing the number of leucocytes in blood comprising a plurality of hollow fibers based on organic polymers, whereby the hollow fibers have a lumen and a wall surrounding the lumen, said wall having an internal surface facing the lumen and an external surface, whereby the hollow fibers are arranged in a cylindrical housing with an inlet arrangement and an outlet arrangement and whereby an outer space is formed between the hollow fibers and the housing, which space is accessible for a fluid via the inlet arrangement and the outlet arrangement, characterized in that only the external surfaces of the hollow fibers are accessible for a fluid, that the lumina of the hollow fibers are not accessible for a fluid, that the arrangement of the hollow fibers shows a high degree of order and that the hollow fibers based on organic polymers cause a generation of the complement activation product C5a in a concentration of at least 10 ?g per m2 of fiber surface.

Abstract: A loudspeaker stand has a mount, onto which a loudspeaker can be placed. For this purpose, the mount has a tensioning device, which can be actuated by the intrinsic weight of the loudspeaker. The stand may have several tensioning elements, which can be shifted in a direction perpendicular to that in which the loudspeaker is set down.

Abstract: The invention relates to a modularly constructed hollow profile, as well as a telescoping carrier, such as a lifting column, that is formed by the modularly constructed hollow profiles.

Abstract: A device for reducing the number of leucocytes in blood comprising a plurality of hollow fibers based on organic polymers, whereby the hollow fibers have a lumen and a wall surrounding the lumen, said wall having an internal surface facing the lumen and an external surface, whereby the hollow fibers are arranged in a cylindrical housing with an inlet arrangement and an outlet arrangement and whereby an outer space is formed between the hollow fibers and the housing, which space is accessible for a fluid via the inlet arrangement and the outlet arrangement, characterized in that only the external surfaces of the hollow fibers are accessible for a fluid, that the lumina of the hollow fibers are not accessible for a fluid, that the arrangement of the hollow fibers shows a high degree of order and that the hollow fibers based on organic polymers cause a generation of the complement activation product C5a in a concentration of at least 10 ?g per m2 of fiber surface.

Abstract: In a method of producing a conductor pattern on a substrate and, in particular, of producing RFID labels, the conductive base material and the substrate material are initially provided, further the conductive base material is punched to obtain a conductor pattern and a residual base material. The conductor pattern is connected to the substrate material, and the residual base material is removed.

Abstract: In a method of producing a conductor pattern on a substrate and, in particular, of producing RFID labels, the conductive base material and the substrate material are initially provided, further the conductive base material is punched to obtain a conductor pattern and a residual base material. The conductor pattern is connected to the substrate material, and the residual base material is removed.

Abstract: In a method of connecting a chip and a substrate, an adhesive having conductive particles is initially provided. The chip and the substrate each include at least one pad on one appropriate side. The adhesive is applied onto one side of the substrate or onto one side of the chip, and the chip and the substrate are connected, the pads being aligned one below the other. Subsequently, this arrangement is pressurized such that in the region between the pads of the chip and the substrate, local compaction of the adhesive results, and the conductive particles adhere to the pads. Finally, the adhesive is hardened.

Abstract: A target classification method for radar systems wherein, in particular, jet aircraft, are classified in that the blade repetition rate and, in a further step, the number of blades, of an engine rotor wheel are determined and thus the type of engine is identified. Helicopters are classified by determining the blade repetition period of the primary or tail rotor.