Abstract: The present invention provides dihydrooxydiazinone compounds of general formula (I): in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.

Abstract: A process for producing a hydrogen product where a carbon-containing input, by reforming and water gas shift, is converted into a synthesis gas largely consisting of hydrogen and carbon dioxide, from which a hydrogen fraction and a carbon dioxide fraction are separated, wherein the hydrogen fraction has the composition required for the hydrogen product and the carbon dioxide fraction has a purity which allows delivery thereof as a product or disposal thereof through sequestration. The characterizing feature here is that the synthesis gas consisting largely of hydrogen and carbon dioxide, by means of a first pressure swing adsorber, is fractionated into a carbon dioxide-depleted first PSA high-pressure fraction and a carbon dioxide-enriched first PSA low-pressure fraction, from which, after compression, the carbon dioxide fraction is obtained by cryogenic gas fractionation.

Abstract: A method and device for the material use of an off-gas which is rich in carbon monoxide and contains hydrocarbons as well as hydrogenatable sulfur compounds, wherein a sulfur-free reformer feed is formed using the off-gas and is subsequently converted by steam reforming into a hydrogen-containing synthesis gas. According to the invention, the off-gas which is rich in carbon monoxide and contains hydrocarbons as well as hydrogenatable sulfur compounds is heated and subjected to hydrolysis at a temperature between 150 and 250° C., preferably between 150 and 190° C., in order to convert the hydrogenatable sulfur compounds with catalytic support into hydrogen sulfide, and to obtain an off-gas which is free of hydrogenatable sulfur compounds and which is subsequently desulfurized over a fixed bed containing zinc oxide.

Abstract: Separating a starting gas mixture using pressure swing adsorption. In this, at least part of a low-pressure extraction flow from the pressure swing adsorption is subjected to a thermal separation, wherein a return fraction is formed in the thermal separation which is returned to the pressure swing adsorption separation. In the thermal separation, counterflow cooling takes place to obtain a two-phase mixture, wherein at least part of the two-phase mixture is subjected to phase separation to obtain a gas phase and a condensate. At least a part of the gas phase is used to form the return fraction, and counterflow cooling is carried out using at least a part of the gas phase and at least a part of one or more fluid flows which are formed by expansion of at least a part of the liquid phase.

Abstract: The present invention features improved compounds, especially methods of identifying patients having cancer using biomarkers (e.g., PDE3A, SLFN12 and/or CREB3L1) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention (e.g., Compounds 1-6 disclosed herein).

Abstract: The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.

Abstract: The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.

Abstract: An electric machine (1) for driving a motor vehicle includes a stator (2) having at least one winding overhang (9, 10). Cooling fluid is flowable in the area of the at least one winding overhang (9, 10) to receive heat from the at least one winding overhang (9, 10). Air is flowable in the area of the at least one winding overhang (9, 10) to receive heat from the cooling fluid.

Abstract: The invention relates to a method and to a device for performing a process (P) having at least one heat-consuming process step (F). A first fluid (2), which arises in the process and contains acid gases and water vapor, is cooled indirectly against a second fluid (7), an acidic condensate thus being formed. The invention is characterized in that the first fluid (2) is cooled in at least two successive steps (E1, E2), between which heat for use in the heat-consuming process step (V) is indirectly drawn from the second fluid (10).

Abstract: A composition that forms an insulating layer contains an epoxy-thiol-based binder. Because the expansion rate of the composition is relatively high, coatings having the layer thickness required for the relevant fire resistance duration can be applied in a simple and rapid manner, and it is possible to reduce the layer thickness to a minimum while still achieving a good insulating effect. The composition is particularly suitable for fire-protection, in particular as a coating for metal and non-metal substrates, e.g., steel components such as supports, beams, and truss members, to increase the fire resistance duration thereof.

Abstract: The present invention provides dihydrooxydiazinone compounds of general formula (I) in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.

Abstract: A portable system for producing a formulation comprising lipid nanoparticle (LNP)-encapsulated RNA includes: a first sub-system comprising multiple drug substance formulation modules, the first sub-system comprising: a transcription module for forming an RNA solution via in vitro transcription; and a second sub-system operatively downstream of the first sub-system comprising multiple drug product formation modules, the second sub-system comprising: an LNP formulation module for producing a first RNA-LNP preparation from the RNA solution, wherein each of the transcription module and the LNP formulation module is contained within a separate standard shipping container.

Abstract: A process for producing a purified hydrogen product without a pre-reformer or pre-reforming catalyst in a fired, tubular reformer where the feed stream having a carbon (i.e., C2+) molar composition greater than or equal to five percent and is mixed with a steam stream to yield a reformer feed stream with a steam-to-carbon ratio less than or equal to three. The reformer tubes contain a nickel-based catalyst without alkali promotion.

Abstract: A heat sink (30) for cooling an electric machine (10), includes: a first part of the heat sink (32) in the form of a hollow cylinder, wherein an inner lateral surface includes a groove (34) extending helically with respect to a central axis of the hollow cylinder; a second part of the heat sink (36) in the form of a hollow cylinder, which includes a radially internal fin (38); and a third part of the heat sink (40) in the form of a hollow cylinder, which includes a connecting section (52), in order to accommodate an output shaft (12) of the machine in a rotationally fixed manner. The second part of the heat sink is accommodated, at least partially, in the first part of the heat sink, so that a radially external surface of the second part of the heat sink rests against the groove.

Abstract: An electric machine includes a stator (1) and a rotor (2), which are arranged in a housing (3). A liquid cooling jacket is configured for cooling the stator (1). At least one extended surface cooler (10), which is connected to the liquid cooling jacket via a housing wall, is provided in an interior of the housing (3) for direct cooling of components arranged in the interior of the housing (3). Moreover, an axle drive of a vehicle may include the electric machine.

Abstract: A holding apparatus/workpiece adapter apparatus arrangement includes a holding apparatus and a workpiece adapter apparatus. The workpiece adapter apparatus is positioned and fixed, with a workpiece fastened thereto, by the holding apparatus. The holding apparatus has partially cylindrical positioning elements, which engage in an associated cylindrical positioning recess and a positioning slot and position the workpiece adapter apparatus in an x and a y direction. The workpiece adapter apparatus bears by mating contact surfaces against contact surfaces of the holding apparatus and is clamped by linearly displaceable clamping elements and pressed against the contact surfaces, and thus positioned in a z direction. For clamping, clamping surfaces of the clamping elements bear against mating clamping surfaces of the workpiece adapter apparatus.

Abstract: A cooling arrangement for an electric machine (1, 1a, 1b) includes a rotatably mounted rotor shaft (2). A rotatably mounted hollow shaft (11) is mounted coaxially to the rotor shaft (2) and rotationally fixed to the rotor shaft (2). A hollow shaft inner side (12) is spaced apart from a rotor shaft outer side (5) in a radial direction (R) in order to form an annular gap (14). At least one cooling duct for a cooling lubricant includes a hollow shaft duct (18), a feed duct (20), and an outlet duct (25). The feed duct (20) opens into the hollow shaft duct (18) in order to feed the cooling lubricant to the hollow shaft duct (18). The outlet duct (25) extends from the hollow shaft duct (18) to the annular gap (14) in order to release the cooling lubricant from the hollow shaft duct (18) into the annular gap (14).

Abstract: A shaft (12) for cooling an electric machine (10) includes: an outer sub-shaft (32), which is designed for being rotationally fixed to a rotor (14) of the electric machine; an inner sub-shaft (30), which is rotationally fixed to the outer sub-shaft and is designed as an output shaft of the electric machine; an inflow (36) arranged in the radial direction between the outer sub-shaft and the inner sub-shaft, in order to supply cooling fluid (28) to the shaft; and an outflow (42) arranged in the radial direction between the outer sub-shaft and the inner sub-shaft, in order to discharge cooling fluid supplied to the shaft. The outer sub-shaft encloses a fluid chamber (40), which is arranged in the axial direction between the inflow and the outflow. A direction of flow of cooling fluid in the fluid chamber is established by a delivery direction of a fluid pump (24).

Abstract: The present invention provides dihydrooxydiazinone compounds of general formula (I): in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.

Abstract: An electric machine (1) for driving a motor vehicle includes a stator (2) having at least one winding overhang (9, 10). Cooling fluid is flowable in the area of the at least one winding overhang (9, 10) to receive heat from the at least one winding overhang (9, 10). Air is flowable in the area of the at least one winding overhang (9, 10) to receive heat from the cooling fluid.