Abstract: Provided herein are compositions comprising a RIPK2 inhibitor and methods of using the RIPK2 inhibitor for treating or preventing neurodegenerative diseases or disorders. Also provided herein are methods of screening or identifying therapeutic agents useful for treating or preventing neurodegenerative diseases or disorders.

Abstract: A method may be implemented by a wireless transmit/receive unit (WTRU). The method may comprise receiving configuration information. The configuration information may comprise information regarding a first discontinuous reception (DRX) cycle with a first periodicity and a second DRX cycle with a second periodicity. The configuration information may comprise a time offset value (T). The configuration information may comprise a threshold value for wake-up signal (WUS) detection. The configuration information may comprise a number (N) of monitoring occasions for missed WUS detections. The method may comprise monitoring for a WUS according to the first periodicity. The method may comprise monitoring for a paging indication according to the second periodicity. The method may comprise monitoring, on a condition that a WUS is not detected. for the paging indication according to the first periodicity. and receiving the paging indication.

Abstract: A method is disclosed comprising: trapping ions in an ion trap (40); applying a first force on the ions within the ion trap in a first direction, said force having a magnitude that is dependent upon the value of a physicochemical property of the ions; applying a second force on these ions in the opposite direction so that the ions separate according to the physicochemical property value as a result of the first and second forces; and then pulsing or driving ions out of one or more regions of the ion trap.

Abstract: Embodiments of process chambers having a collimator are provided herein. In some embodiments, a process chamber includes: a chamber body having sidewalls and a top plate to define an interior volume therein, the top plate configured to support a target in the interior volume; a substrate support disposed in the interior volume opposite the top plate; a collimator disposed in the interior volume between the top plate and the substrate support; and a lower shield disposed in the interior volume about the collimator and coupled to the chamber body at a location below an upper surface of the collimator via a ceramic spacer disposed between the lower shield and the chamber body configured to electrically decouple the lower shield from the chamber body.

Abstract: Devices, methods, and systems for hands free facility status alerts are described herein. One system includes a computing device for hands free building automation notifications, comprising a memory and a processor to execute executable instructions stored in the memory to: receive a notification of an event from a building automation system, modify the notification to include only pre-defined attributes of the notification that are displayable on a user interface of a wearable device, and transmit the modified notification to the wearable device.

Abstract: A technique facilitates deploying and setting a liner hanger assembly while securely retaining liner hanger slips during running-in-hole. The liner hanger assembly may comprise a variety of components such as a mandrel, a cone, a plurality of slips, a retention ring, and an actuator. The slips may each be configured with an upper retention end and a lower retention end having a plurality of angles which interlock with corresponding angles of the cone and the retention ring. Additionally, a portion of the actuator may be sized to slide over an axial end of the retention ring to prevent inadvertent decoupling of the slips after installing the slips along the exterior of the cone.

Abstract: A method of suppressing contrails emitted by a propulsion system of an aircraft. A first fuel composition is fed into the propulsion system for a predetermined period. The expiry of the predetermined period is detected with a timer. Upon expiry of the predetermined period, a second fuel composition is fed into the propulsion system. The second fuel composition is more prone to cause contrails than the first fuel composition. Contrails generated by the propulsion system are detected as the second fuel composition is fed into the propulsion system. If a contrail is detected, the steps of the method are repeated.

Abstract: A microfluidic system is presented that includes a cartridge, a container, and a lid for the container. The cartridge includes a plurality of microfluidic channels coupled to one or more chambers. The container holds dry chemicals and includes a housing with a first opening and a second opening smaller than the first opening. The container is designed to be inserted into an opening of the cartridge, such that the container is independently secured within the opening. The insertion of the container allows for the container to be fluidically coupled with a microfluidic channel of the plurality of microfluidic channels via the second opening. The lid includes a column that extends from the lid into the container.

Abstract: A system for use in a well includes a liner hanger including a mandrel, a cone mounted about the mandrel, the cone having tapered slips, a plurality of tapered slips slidably received in the tapered slots, each tapered slip of the plurality of tapered slips comprising a plurality of teeth, wherein each tapered slip of the plurality of tapered slips and the corresponding tapered slot includes a setting ramp, and a loading ramp separate from the setting ramp, and an actuator mounted about the mandrel to selectively shift the plurality of tapered slips between a radially contracted position and a radially expanded, set position.

Abstract: The present disclosure generally relates to a telescoping support bracket, a box bracket, a conduit support bracket, and a floor support bracket. The telescoping support bracket generally comprises telescoping arms that allow the length of the bracket to be adjusted. A method of installing the telescoping support bracket is also provided.

Abstract: A technique facilitates deploying and setting a liner hanger assembly while securely retaining liner hanger slips during running-in-hole. The liner hanger assembly may comprise a variety of components such as a mandrel, a cone, a plurality of slips, a retention ring, and an actuator. The slips may each be configured with an upper retention end and a lower retention end having a plurality of angles which interlock with corresponding angles of the cone and the retention ring. Additionally, a portion of the actuator may be sized to slide over an axial end of the retention ring to prevent inadvertent decoupling of the slips after installing the slips along the exterior of the cone.

Abstract: Technology is disclosed herein for an application service which interfaces with an LLM service. In an implementation, the application service receives a natural language input from a user associated with a spreadsheet. The application service generates a prompt based on the user input and at least a portion of the spreadsheet and submits the prompt to a large language model (LLM) service. The application service receives a reply to the prompt from the LLM service and responds to the input based on the reply from the LLM service.

Abstract: The present disclosure provides TGF? inhibitor therapy for treating immunosuppressive conditions, cancer, and fibrosis, either as a monotherapy or combination/adjunct therapy. Selection of suitable therapy and patients who are likely to benefit from such therapy are also disclosed, as well as methods of treating cancer and fibrosis and methods of predicting and monitoring therapeutic response. Related compositions, methods and therapeutic use are also disclosed.

Abstract: A method is disclosed comprising: trapping ions in an ion trap (40); applying a first force on the ions within the ion trap in a first direction, said force having a magnitude that is dependent upon the value of a physicochemical property of the ions; applying a second force on these ions in the opposite direction so that the ions separate according to the physicochemical property value as a result of the first and second forces; and then pulsing or driving ions out of one or more regions of the ion trap.

Abstract: The present disclosure relates to systems, apparatuses, and methods for assembling cartridges for aerosol delivery devices. A system may include assembly cells each including an assembly track and assembly carriages that ride thereon and which engage components of partially-assembled cartridges. A transfer apparatus may transfer partially-assembled cartridges between the assembly cells. In another example system, cartridges may be assembled on platforms on a rotary track. The platforms may include assembly grippers with sequentially-opening clamps configured to receive the components of the partially-assembled cartridges. Related methods are also provided.

Abstract: A microelectronic device comprises, a control circuitry structure comprising an active region including control logic circuitry at least partially within a semiconductive material; a bond pad on a backside of the control circuitry structure; a conductive contact vertically extending from the bond pad, through the semiconductive material, and to the control logic circuitry; and a dielectric-filled slit vertically extending into the semiconductive material and horizontally circumscribing the conductive contact, portions of the semiconductive material horizontally interposed between the conductive contact and the dielectric-filled slit. Additional microelectronic devices, memory devices, microelectronic device packages, and electronic systems are also described.

Abstract: A mounting bracket attaches a junction box to a support structure. The mounting bracket includes a body portion and a locking portion attached to the body portion. The body portion includes at least one attachment feature for attaching the mounting bracket to a support structure. The locking portion includes first and second locking arms that extend from the body portion. At least one of the locking arms is receivable within an opening in the junction box. The first and second locking arms may be moveable relative to each other to engage the locking arms, lock the second locking arm to the first locking arm, and secure the mounting bracket to the junction box when the first locking arm is received in the opening in the junction box.

Abstract: A mounting bracket for a junction box includes a face plate having left and right edge margins and a central opening. The face plate includes a first set of indicia adjacent a top edge of the central opening and a second set of indicia adjacent a bottom edge of the central opening. Each set of indicia includes ruler graduations indicating a distance from the left edge margin of the face plate to the respective ruler graduation.