Patents by Inventor Martin Linsell

Martin Linsell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Factor VIII zwitterionic polymer conjugates
    Patent number: 12214044
    Abstract: The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.
    Type: Grant
    Filed: February 7, 2023
    Date of Patent: February 4, 2025
    Assignee: KODIAK SCIENCES INC.
    Inventors: Stephen A. Charles, Daniel Victor Perlroth, Li Song, Martin Linsell, Wayne To, Didier Benoit, James Aggen
  • Compounds, Compositions and Methods for Attenuation of Mammalian Translation of C-MYC or N-MYC Proteins of the MYC Proto-Oncogene Family of BHLH Transcription Factors
    Publication number: 20240400555
    Abstract: A method of modulating c-MYC activity is disclosed.
    Type: Application
    Filed: April 26, 2024
    Publication date: December 5, 2024
    Applicant: Initial Therapeutics, Inc.
    Inventors: Phillip A. Patten, Jim Li, Brooke Olson Blair, Pingyu Ding, Yi Chiao Fan, Margot Paulick, Martin Linsell
  • FACTOR VIII ZWITTERIONIC POLYMER CONJUGATES
    Publication number: 20230173081
    Abstract: The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.
    Type: Application
    Filed: February 7, 2023
    Publication date: June 8, 2023
    Inventors: Stephen A. Charles, Daniel Victor Perlroth, Li Song, Martin Linsell, Wayne To, Didier Benoit, James Aggen
  • Factor VIII zwitterionic polymer conjugates
    Patent number: 11590235
    Abstract: The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: February 28, 2023
    Assignee: Kodiak Sciences Inc.
    Inventors: Stephen A. Charles, Daniel Victor Perlroth, Li Song, Martin Linsell, Wayne To, Didier Benoit, James Aggen
  • Butyrylcholinesterase zwitterionic polymer conjugates
    Patent number: 11071771
    Abstract: The present invention provides recombinant butyrylcholinesterase fusion proteins, including Fc fusion proteins and multi-armed high MW polymers containing hydrophilic groups conjugated to the fusion proteins, and methods of preparing such polymers.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: July 27, 2021
    Assignee: Kodiak Sciences Inc.
    Inventors: Daniel Victor Perlroth, Stephen A. Charles, Wayne To, Xiaojian Huang, Martin Linsell, Didier Benoit
  • FACTOR VIII ZWITTERIONIC POLYMER CONJUGATES
    Publication number: 20200261590
    Abstract: The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.
    Type: Application
    Filed: February 4, 2020
    Publication date: August 20, 2020
    Inventors: Stephen A. Charles, D. Victor Perlroth, Li Song, Martin Linsell, Wayne To, Didier Benoit, James Aggen
  • Factor VIII zwitterionic polymer conjugates
    Patent number: 10702608
    Abstract: The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: July 7, 2020
    Assignee: KODIAK SCIENCES INC.
    Inventors: Stephen A. Charles, D. Victor Perlroth, Li Song, Martin Linsell, Wayne To, Didier Benoit, James Aggen
  • BUTYRYLCHOLINESTERASE ZWITTERIONIC POLYMER CONJUGATES
    Publication number: 20190255155
    Abstract: The present invention provides recombinant butyrylcholinesterase fusion proteins, including Fc fusion proteins and multi-armed high MW polymers containing hydrophilic groups conjugated to the fusion proteins, and methods of preparing such polymers.
    Type: Application
    Filed: May 3, 2019
    Publication date: August 22, 2019
    Inventors: D. Victor Perlroth, Stephen A. Charles, Wayne To, Xiaojian Huang, Martin Linsell, Didier Benoit
  • Butyrylcholinesterase zwitterionic polymer conjugates
    Patent number: 10363290
    Abstract: The present invention provides recombinant butyrylcholinesterase fusion proteins, including Fc fusion proteins and multi-armed high MW polymers containing hydrophilic groups conjugated to the fusion proteins, and methods of preparing such polymers.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: July 30, 2019
    Assignee: KODIAK SCIENCES INC.
    Inventors: D. Victor Perlroth, Stephen A. Charles, Wayne To, Xiaojian Huang, Martin Linsell, Didier Benoit
  • METHODS OF ESTIMATING LOGD OF TAGGED COMBINATORIAL LIBRARY COMPOUNDS
    Publication number: 20170153257
    Abstract: Disclosed herein are methods of estimating LogD of compounds comprising a ligand operatively linked to a recognition element. The methods generally involve contacting the compounds with a matrix, measuring the interaction of the compounds with the matrix and relating the interaction of the compounds with the matrix to LogD of the compounds. Also, described herein, are novel compounds which include a ligand operatively linked to a recognition element and linkers that connect the ligand to the recognition element.
    Type: Application
    Filed: October 10, 2016
    Publication date: June 1, 2017
    Inventors: Phillip Patten, Pehr Harbury, Donald Schmidt, Martin Linsell, Kenneth Wlasichuk, Robin Prince, Timothy J. Church, Wouter Van der Linden
  • FACTOR VIII ZWITTERIONIC POLYMER CONJUGATES
    Publication number: 20160199501
    Abstract: The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.
    Type: Application
    Filed: September 8, 2014
    Publication date: July 14, 2016
    Inventors: Stephen A. Charles, D. Victor Perlroth, Li Song, Martin Linsell, Wayne To, Didier Benoit, James Aggen
  • BUTYRYLCHOLINESTERASE ZWITTERIONIC POLYMER CONJUGATES
    Publication number: 20160184445
    Abstract: The present invention provides recombinant butyrylcholinesterase fusion proteins, including Fc fusion proteins and multi-armed high MW polymers containing hydrophilic groups conjugated to the fusion proteins, and methods of preparing such polymers.
    Type: Application
    Filed: November 4, 2015
    Publication date: June 30, 2016
    Inventors: D. Victor Perlroth, Stephen A. Charles, Wayne To, Xiaojian Huang, Martin Linsell, Didier Benoit
  • ANTIBACTERIAL 1,4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS
    Publication number: 20080300199
    Abstract: The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
    Type: Application
    Filed: April 10, 2008
    Publication date: December 4, 2008
    Applicant: Achaogen Inc.
    Inventors: Martin Linsell, Adam Aaron Goldblum, James Aggen, Heinz Ernst Moser, Stephen Hanessian, Kandasamy Pachamuthu, Ellen Klegraf
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Publication number: 20080108558
    Abstract: This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: October 25, 2007
    Publication date: May 8, 2008
    Inventors: Paul Fatheree, Martin Linsell, Daniel Long, Daniel Marquess, Edmund Moran, Matthew Nodwell, S. Derek Turner, James Aggen
  • Glycopeptide derivatives and pharmaceutical compositions containing the same
    Publication number: 20080103292
    Abstract: Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb-(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Application
    Filed: October 24, 2007
    Publication date: May 1, 2008
    Inventors: J. Judice, Paul Fatheree, Bernice Lam, Michael Leadbetter, Martin Linsell, YongQi Mu, Sean Trapp, Guang Yang, Yan Zhu
  • Cross-linked glycopeptide - cephalosporin antibiotics
    Publication number: 20080103299
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: December 19, 2007
    Publication date: May 1, 2008
    Inventors: Paul Fatheree, Martin Linsell, Daniel Marquess, Daniel Long, Jason Chinn, Matthew Nodwell, Edmund Moran, James Aggen
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Publication number: 20080051577
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: August 24, 2007
    Publication date: February 28, 2008
    Inventors: Paul Fatheree, Martin Linsell, Daniel Marquess, S. Turner
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Publication number: 20080045721
    Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: August 24, 2007
    Publication date: February 21, 2008
    Inventors: Paul Fatheree, Martin Linsell, Daniel Long, Daniel Marquess, Edmund Moran, Matthew Nodwell, S. Derek Turner, James Aggen
  • Cross-linked glycopeptide-cephalosporin antibiotics
    Publication number: 20080039611
    Abstract: This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: August 24, 2007
    Publication date: February 14, 2008
    Inventors: Paul Fatheree, Martin Linsell, Daniel Long, Daniel Marquess, Edmund Moran, Matthew Nodwell, S. Derek Turner, James Aggen
  • Diamine Beta2 Adrenergic Receptor Agonists
    Publication number: 20080039495
    Abstract: The invention provides novel ?2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with ?2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: June 2, 2005
    Publication date: February 14, 2008
    Inventor: Martin Linsell