Patents by Inventor Martin M. Okun

Martin M. Okun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR TREATMENT OF SKIN DISORDERS
    Publication number: 20180044414
    Abstract: The invention provides methods and compositions for the treatment of a skin disorder associated with detrimental TNF? activity, such as psoriasis. The invention includes methods for treating a skin disorder associated with detrimental TNF? activity, such as psoriasis, in a subject who has failed or lost response to prior biologic therapy, such as prior administration of etanercept. The invention further provides methods for determining the efficacy of a human TNF? antibody, or antigen-binding portion thereof, for the treatment of a skin disorder associated with detrimental TNF? activity, such as psoriasis.
    Type: Application
    Filed: March 27, 2017
    Publication date: February 15, 2018
    Inventors: Martin M. Okun, Rebecca S. Hoffman, Jonathan Barker
  • Use of TNFalpha Antibody for Treatment of Hidradenitis Suppurativa (HS)
    Publication number: 20170101465
    Abstract: The invention provides methods, uses and compositions for the treatment of hidradenitis suppurativa. The invention describes methods and uses for treating hidradenitis suppurativa, wherein a TNF? inhibitor, such as a human TNF? antibody, or antigen-binding portion thereof, is used to treat hidradenitis suppurativa in a subject. Also described are methods for determining the efficacy of a TNF? inhibitor for treating hidradenitis suppurativa in a subject.
    Type: Application
    Filed: May 6, 2016
    Publication date: April 13, 2017
    Inventors: Martin M. Okun, Thomas C. Harris
  • Methods and compositions for treatment of skin disorders
    Patent number: 9605064
    Abstract: The invention provides methods and compositions for the treatment of a skin disorder associated with detrimental TNF? activity, such as psoriasis. The invention includes methods for treating a skin disorder associated with detrimental TNF? activity, such as psoriasis, in a subject who has failed or lost response to prior biologic therapy, such as prior administration of etanercept. The invention further provides methods for determining the efficacy of a human TNF? antibody, or antigen-binding portion thereof, for the treatment of a skin disorder associated with detrimental TNF? activity, such as psoriasis.
    Type: Grant
    Filed: August 18, 2010
    Date of Patent: March 28, 2017
    Assignee: AbbVie Biotechnology Ltd
    Inventors: Martin M. Okun, Rebecca S. Hoffman, Jonathan Barker
  • Uses and Compositions for Treatment of Psoriasis
    Publication number: 20160200809
    Abstract: The invention provides methods, uses and compositions for the treatment of psoriasis. The invention describes methods and uses for treating psoriasis, wherein a TNF? inhibitor, such as a human TNF? antibody, or antigen-binding portion thereof, is used to treat psoriasis in a subject. Also described are methods for determining the efficacy of a TNF? inhibitor for treatment of psoriasis in a subject.
    Type: Application
    Filed: August 17, 2015
    Publication date: July 14, 2016
    Inventors: Mary K. Willian, Martin M. Okun, Rebecca S. Hoffman, Yihua Gu, Lisa E. Melilli, Kenneth B. Gordon
  • Methods of treating moderate to severe hidradenitis suppurativa with anti-TNFalpha antibody
    Patent number: 9334320
    Abstract: The invention provides methods, uses and compositions for the treatment of hidradenitis suppurativa. The invention describes methods and uses for treating hidradenitis suppurativa, wherein a TNF? inhibitor, such as a human TNF? antibody, or antigen-binding portion thereof, is used to treat hidradenitis suppurativa in a subject. Also described are methods for determining the efficacy of a TNF? inhibitor for treating hidradenitis suppurativa in a subject.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: May 10, 2016
    Assignee: AbbVie Biotechnology Ltd.
    Inventors: Martin M. Okun, Thomas C. Harris
  • Use of TNFalpha Antibody for Treatment of Hidradenitis Suppurativa (HS)
    Publication number: 20150147335
    Abstract: The invention provides methods, uses and compositions for the treatment of hidradenitis suppurativa. The invention describes methods and uses for treating hidradenitis suppurativa, wherein a TNF? inhibitor, such as a human TNF? antibody, or antigen-binding portion thereof, is used to treat hidradenitis suppurativa in a subject. Also described are methods for determining the efficacy of a TNF? inhibitor for treating hidradenitis suppurativa in a subject.
    Type: Application
    Filed: May 28, 2014
    Publication date: May 28, 2015
    Inventors: Martin M. Okun, Thomas C. Harris
  • Uses and Compositions for Treatment of Psoriasis
    Publication number: 20150050216
    Abstract: The invention provides methods, uses and compositions for the treatment of psoriasis. The invention describes methods and uses for treating psoriasis, wherein a TNF? inhibitor, such as a human TNF? antibody, or antigen-binding portion thereof, is used to treat psoriasis in a subject. Also described are methods for determining the efficacy of a TNF? inhibitor for treatment psoriasis in a subject.
    Type: Application
    Filed: July 8, 2014
    Publication date: February 19, 2015
    Inventors: Mary Kaye Willian, Martin M. Okun, Rebecca S. Hoffman, Yihua Gu, Lisa E. Melilli, Kenneth B. Gordon, Subhashis Banerjee, Lori K. Taylor, Daniel E. Tracey, Elliot K. Chartash, William T. Barchuk, Philip Yan, Anwar Murtaza, Jochen G. Salfeld, Steven A. Fischkoff, George R. Granneman
  • Methods of treating moderate to severe hidradenitis suppurativa with anti-TNF-alpha antibodies
    Patent number: 8747854
    Abstract: The invention provides methods, uses and compositions for the treatment of hidradenitis suppurativa. The invention describes methods and uses for treating hidradenitis suppurativa, wherein a TNF? inhibitor, such as a human TNF? antibody, or antigen-binding portion thereof, is used to treat hidradenitis suppurativa in a subject. Also described are methods for determining the efficacy of a TNF? inhibitor for treating hidradenitis suppurativa in a subject.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: June 10, 2014
    Assignee: AbbVie Biotechnology Ltd.
    Inventors: Martin M. Okun, Thomas C. Harris
  • METHODS FOR TREATING PSORIASIS
    Publication number: 20140079714
    Abstract: The invention provides methods of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23.
    Type: Application
    Filed: September 11, 2013
    Publication date: March 20, 2014
    Inventors: Joaquin Mario Valdes, Elliot K. Chartash, William T. Barchuk, Susan K. Paulson, Kenneth B. Gordon, Walid M. Awni, Yanjun Bao, William G. Glass, Yihua Gu, Thomas C. Harris, Martin Kaul, Parvez M. Mulani, Peter A. Noertersheuser, Martin M. Okun
  • Methods for treating psoriasis using antibodies that bind to the P40 subunit of IL-12 and/or IL-23
    Patent number: 8557239
    Abstract: The invention provides methods of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: October 15, 2013
    Assignees: AbbVie Inc., AbbVie Deutschland GmbH & Co. KG
    Inventors: Joaquin Mario Valdes, Elliot K. Chartash, William T. Barchuk, Susan K. Paulson, Kenneth B. Gordon, Walid M. Awni, Yanjun Bao, William G. Glass, Yihua Gu, Tom C. Harris, Martin Kaul, Parvez M. Mulani, Peter Noertersheuser, Martin M. Okun
  • USES AND COMPOSITIONS FOR TREATMENT OF PSORIASIS AND CROHN'S DISEASE
    Publication number: 20120282262
    Abstract: The invention provides methods, uses and compositions for the treatment of psoriasis or Crohn's disease. The invention describes methods and uses for treating psoriasis or Crohn's disease, wherein a TNF? inhibitor, such as a human TNF? antibody, or antigen-binding portion thereof, is used to treat psoriasis in a subject. The invention includes methods of improving patient reported outcomes using a human human TNF? antibody, or antigen-binding portion thereof, for the treatment of Crohn's or psoriasis. The invention also provides methods of improving fatigue or depression in patients having Crohns'.
    Type: Application
    Filed: January 9, 2012
    Publication date: November 8, 2012
    Inventors: Martin M. Okun, Rebecca S. Hoffman, Thomas C. Harris, Parvez M. Mulani, Jingdong Chao, Talat Ashraf
  • USES AND COMPOSITIONS FOR TREATMENT OF HIDRADENITIS SUPPURATIVA (HS)
    Publication number: 20110300151
    Abstract: The invention provides methods, uses and compositions for the treatment of hidradenitis suppurativa. The invention describes methods and uses for treating hidradenitis suppurativa, wherein a TNF? inhibitor, such as a human TNF? antibody, or antigen-binding portion thereof, is used to treat hidradenitis suppurativa in a subject. Also described are methods for determining the efficacy of a TNF? inhibitor for treating hidradenitis suppurativa in a subject.
    Type: Application
    Filed: June 3, 2011
    Publication date: December 8, 2011
    Inventors: Martin M. OKUN, Thomas C. Harris
  • METHODS AND COMPOSITIONS FOR TREATMENT OF SKIN DISORDERS
    Publication number: 20110171227
    Abstract: The invention provides methods and compositions for the treatment of a skin disorder associated with detrimental TNF? activity, such as psoriasis. The invention includes methods for treating a skin disorder associated with detrimental TNF? activity, such as psoriasis, in a subject who has failed or lost response to prior biologic therapy, such as prior administration of etanercept. The invention further provides methods for determining the efficacy of a human TNF? antibody, or antigen-binding portion thereof, for the treatment of a skin disorder associated with detrimental TNF? activity, such as psoriasis.
    Type: Application
    Filed: August 18, 2010
    Publication date: July 14, 2011
    Inventors: Martin M. Okun, Rebecca S. Hoffman, Jonathan Barker
  • Uses and Compositions for treatment of Psoriasis and Crohn's Disease
    Publication number: 20100003243
    Abstract: The invention provides methods, uses and compositions for the treatment of psoriasis or Crohn's disease. The invention describes methods and uses for treating psoriasis or Crohn's disease, wherein a TNF? inhibitor, such as a human TNF? antibody, or antigen-binding portion thereof, is used to treat psoriasis in a subject. The invention includes methods of improving patient reported outcomes using a human TNF? antibody, or antigen-binding portion thereof, for the treatment of Crohn's or psoriasis. The invention also provides methods of improving fatigue or depression in patients having Crohns'.
    Type: Application
    Filed: January 12, 2009
    Publication date: January 7, 2010
    Inventors: MARTIN M. OKUN, REBECCA S. HOFFMAN, THOMAS C. HARRIS, PARVEZ M. MULANI, JINGDONG CHAO, Talat Ashraf
  • Uses and Compositions for Treatment of Psoriasis
    Publication number: 20090280065
    Abstract: The invention provides methods, uses and compositions for the treatment of psoriasis. The invention describes methods and uses for treating psoriasis, wherein a TNF? inhibitor, such as a human TNF? antibody, or antigen-binding portion thereof, is used to treat psoriasis in a subject. Also described are methods for determining the efficacy of a TNF? inhibitor for treatment psoriasis in a subject.
    Type: Application
    Filed: March 11, 2009
    Publication date: November 12, 2009
    Inventors: Mary K. Willian, Martin M. Okun, Rebecca S. Hoffman, Yihua Gu, Lisa Melilli, Kenneth B. Gordon