Patents by Inventor Martin Maier

Martin Maier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200297853
    Abstract: The present invention provides a phosphorothioate-modified oligonucleotide comprising a structure shown below: The present invention also provides a phosphorothioate-modified oligonucleotide comprising a structure having formula (CIII):
    Type: Application
    Filed: April 29, 2020
    Publication date: September 24, 2020
    Inventors: Muthiah MANOHARAN, Kallanthottathil G. RAJEEV, Jayaprakash NAIR, Martin MAIER
  • Patent number: 10779769
    Abstract: There is described a method for evaluating a level of noise in a biosignal, the method comprising: receiving a time signal representative of a biological activity, the time signal comprising a biological activity component and a noise component; determining a modulation spectrum for the time signal, the modulation spectrum representing a signal frequency as a function of a modulation frequency; from the modulation spectrum determining a first amount of modulation energy corresponding to the biological activity component and a second amount of modulation energy corresponding to the noise component determining an indication of the level of noise using the first and second amounts of modulation energy; and outputting the indication of the level of noise.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: September 22, 2020
    Assignee: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Tiago Henrique Falk, Diana Patricia Tobon Vallejo, Martin Maier
  • Publication number: 20200291405
    Abstract: The present invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the hepatitis D virus (HDV) genome, and methods of using such RNAi agents to inhibit expression of one or more HBV genes and methods of treating subjects having an HDV infection and/or HDV-associated disorder.
    Type: Application
    Filed: February 26, 2020
    Publication date: September 17, 2020
    Inventors: Gregory Hinkle, Laura Sepp-Lorenzino, Vasant R. Jadhav, Martin A. Maier, Muthiah Manoharan, Stuart Milstein, Svetlana Shulga Morskaya, Kallanthottathil G. Rajeev, Huilei Xu
  • Publication number: 20200289371
    Abstract: The invention relates to a set of scales and to an installation for producing a medical composition using a set of scales. The set of scales comprise interchangeable securing means for a target container, the weight thereof being measured by the set of scales.
    Type: Application
    Filed: March 15, 2017
    Publication date: September 17, 2020
    Inventors: Martin Biehl, Michael Hock, Ulla Schobel, Marcel Borgward, Holger Lenkeit, Dirk Lamprecht, Sebastian Maier
  • Publication number: 20200263176
    Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) targeting an APOC3 gene, and methods of using the dsRNA to inhibit expression of APOC3.
    Type: Application
    Filed: December 2, 2019
    Publication date: August 20, 2020
    Inventors: Brian Bettencourt, Kevin Fitzgerald, Stuart Milstein, Martin A. Maier, Klaus Charisse, Kallanthottathil Rajeev, Satyanarayana Kuchimanchi, Muthiah Manoharan, Tuyen Nguyen
  • Patent number: 10738748
    Abstract: A fluid metering valve includes a valve needle that is actuatable by an electromagnetic actuator that includes an armature guided on and along a longitudinal axis of the valve needle with a movement limited by a stop surface on the valve needle. A projection of an edge of the stop surface extends into a projection plane, perpendicular to the longitudinal axis and at which the armature and stop surface are in contact temporarily during operation, through an opening of a conduit of the armature, dividing the opening into an inner surface on one side of the projection and an outer surface on the other side of the projection. A fluid exchange between inside and outside of an area between the stop surface and armature is via a path through the inner surface, conduit, and outer surface when the armature is in contact with the stop surface at the projection plane.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: August 11, 2020
    Assignee: Robert Bosch GmbH
    Inventors: Nico Herrmann, Andreas Schaad, Joerg Abel, Juergen Maier, Martin Buehner, Matthias Boee, Olaf Schoenrock, Philipp Rogler, Stefan Cerny
  • Patent number: 10740488
    Abstract: A computer implemented method for data anonymization comprises: receiving a request for data that needs anonymization. The request comprises at least one field descriptor of data to be retrieved and a usage scenario of a user for the requested data. Then, based on the usage scenario, an anonymization algorithm to be applied to the data that is referred to by the field descriptor is determined. Subsequently, the determined anonymization algorithm is applied to the data that is referred to by the field descriptor. A testing is performed, as to whether the degree of anonymization fulfills a requirement that is related to the usage scenario. In the case, the requirement is fulfilled, access to the anonymized data is provided.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: August 11, 2020
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Albert Maier, Martin Oberhofer, Yannick Saillet
  • Publication number: 20200239890
    Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) targeting a PROC gene, and methods of using the dsRNA to inhibit expression of PROC.
    Type: Application
    Filed: November 11, 2019
    Publication date: July 30, 2020
    Inventors: Ivanka Toudjarska, John M. Maraganore, Brian Bettencourt, Stuart Milstein, Martin A. Maier, Klaus Charisse, Kallanthottathil Rajeev, Satyanarayana Kuchimanchi
  • Patent number: 10719627
    Abstract: A computer implemented method for data anonymization comprises: receiving a request for data that needs anonymization. The request comprises at least one field descriptor of data to be retrieved and a usage scenario of a user for the requested data. Then, based on the usage scenario, an anonymization algorithm to be applied to the data that is referred to by the field descriptor is determined. Subsequently, the determined anonymization algorithm is applied to the data that is referred to by the field descriptor. A testing is performed, as to whether the degree of anonymization fulfills a requirement that is related to the usage scenario. In the case, the requirement is fulfilled, access to the anonymized data is provided.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: July 21, 2020
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Albert Maier, Martin Oberhofer, Yannick Saillet
  • Publication number: 20200224201
    Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ANGPTL3 gene, as well as methods of inhibiting epression of ANGPTL3 and methods of treating subjects having a disorder of lipid metabolism, such as hyperlipidemia or hypertriglyceridemia, using such dsRNA compositions.
    Type: Application
    Filed: December 12, 2019
    Publication date: July 16, 2020
    Inventors: William Querbes, Kevin Fitzgerald, James Butler, Stephanie Williams, Gregory Hinkle, Martin A. Maier
  • Patent number: 10711750
    Abstract: A valve for metering a fluid. An armature of the electromagnetic actuator is movable along a longitudinal axis of a valve needle, the movement of the armature relative to the valve needle being limited by a stop surface on the valve needle. The armature has a passage channel. The stop surface is on a stop element. The stop element and the armature are such that during operation there always remains an intermediate space, adjoining the valve needle, between the stop element and an end face of the armature facing the stop element. The stop surface lies, in a contact region, on the end surface of the armature facing the stop element when the armature and the stop surface come into contact during operation, the contact region being situated between the intermediate space and an opening of the passage channel when the armature and the stop surface come into contact.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: July 14, 2020
    Assignee: Robert Bosch GmbH
    Inventors: Andreas Schaad, Joerg Abel, Juergen Maier, Martin Buehner, Matthias Boee, Olaf Schoenrock, Philipp Rogler, Stefan Cerny
  • Publication number: 20200216844
    Abstract: The invention relates to iRNA, e.g., double-stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of Serpinc1 and methods of treating subjects having a bleeding disorder, such as a hemophilia.
    Type: Application
    Filed: December 14, 2018
    Publication date: July 9, 2020
    Inventors: Akin Akinc, Alfica Sehgal, Ivanka Toudjarska, Donald Foster, Stuart Milstein, Brian Bettencourt, Martin A. Maier, Klaus Charisse, Satyanarayana Kuchimanchi, Kallanthottathil G. Rajeev, Muthiah Manoharan
  • Publication number: 20200199591
    Abstract: The present invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the apolipoprotein C3 (APOC3) gene, and methods of using such RNAi agents to inhibit expression of APOC3 and methods of treating subjects having an APOC3 associated disorder, e.g., hypertriglyceridemia.
    Type: Application
    Filed: August 7, 2019
    Publication date: June 25, 2020
    Inventors: Kevin Fitzgerald, William Querbes, James Butler, Stephanie Williams, Abigail Liebow, Gregory Hinkle, Martin A. Maier, Stuart Milstein, Satyanarayana Kuchimanchi, Muthiah Manoharan
  • Patent number: 10683501
    Abstract: The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the transthyretin (TTR) gene and methods of using such iRNA agents for treating or preventing TTR-associated diseases.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: June 16, 2020
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Tracy Zimmermann, Amy Chan, Vasant R. Jadhav, Martin A. Maier, Kallanthottathil G. Rajeev
  • Patent number: 10683504
    Abstract: The invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the Serpina1 gene, and methods of using such RNAi agents to inhibit expression of Serpina1 and methods of treating subjects having a Serpina1 associated disease, such as a liver disorder.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: June 16, 2020
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Alfica Sehgal, Klaus Charisse, Brian Bettencourt, Martin A. Maier, Kallanthottathil G. Rajeev, Gregory Hinkle, Muthiah Manoharan
  • Publication number: 20200186666
    Abstract: The invention refers to a system for analyzing a document. Each of two measurement arrangements includes two components being a radiation source and a radiation detector, respectively. The two measurement arrangements provide measurement data and differ from each other with regard to a measurement principle, a kind of radiation source, a kind of radiation detector, a kind of relative movement between the document and a component, a kind of relative arrangement of the two components to each other, a kind of emitted radiation, a kind of received radiation or a kind of processing information about radiation emitted by the respective radiation source and/or about radiation received by the respective radiation detector. An evaluator provides data based on the measurement data. The invention also refers to a corresponding method.
    Type: Application
    Filed: February 18, 2020
    Publication date: June 11, 2020
    Inventors: Tobias SCHOEN, Wolfgang HOLUB, Daniel STROMER, Andreas MAIER, Gisela ANTON, Michel THILO, Martin VOSSIEK, Jan SCHUER
  • Patent number: 10668170
    Abstract: One aspect of the present invention relates to double-stranded RNAi (dsRNA) duplex agent capable of inhibiting the expression of a target gene. The dsRNA duplex comprises one or more motifs of three identical modifications on three consecutive nucleotides in one or both strand, particularly at or near the cleavage site of the strand. Other aspects of the invention relates to pharmaceutical compositions comprising these dsRNA agents suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA agents, e.g., for the treatment of various disease conditions.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: June 2, 2020
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Kallanthottathil G. Rajeev, Tracy Zimmermann, Muthiah Manoharan, Martin Maier, Satyanarayana Kuchimanchi, Klaus Charisse
  • Publication number: 20200166553
    Abstract: A measurement system for matching and/or transmission measurements with respect to a device under test comprising an interface is provided. Said measurement system comprises at least one signal generator comprising at least one signal generator signal path, and at least one receiver comprising at least two receiver signal paths. In this context, a signal of a first signal generator signal path of the at least one signal generator signal path and/or a signal of a first receiver signal path of the at least two receiver signal paths is adaptively phase-shifted and/or amplitude-modified with respect to a signal of a second receiver signal path of the at least two receiver signal paths.
    Type: Application
    Filed: November 26, 2018
    Publication date: May 28, 2020
    Inventors: Martin BLOSS, Thomas MAIER
  • Patent number: 10652995
    Abstract: The invention relates to an electronic module (100) mounted on a transmission component (112). The electronic module (100) comprises a printed circuit board element (102) that has component side (104) with at least one electronic component (108) and a contact side (106) lying opposite the component side (104), and a heat conducting film (110) that is placed between a surface section of the contact side (106) lying opposite the component (108) and a surface section of the transmission component (112). The printed circuit board element (102) can be or is tightened to the transmission component (112) such that the heat conducting film (110) is pressed against the surface section of the contact side (106) and the surface section of the transmission component (112).
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: May 12, 2020
    Assignee: ZF Friedrichshafen AG
    Inventors: Hermann Josef Robin, Martin Hempen, Thomas Maier
  • Publication number: 20200144898
    Abstract: An EC motor for an electric hand tool having a stator in which a rotor is rotatably mounted, which comprises a rotor lamination stack, which has a passage opening and is formed of individual laminations, and a rotor shaft which is cast in the passage opening of the rotor lamination stack by means of a casting compound, and having a plurality of permanent magnets, which are received in the pockets formed in the rotor lamination stack. An annular channel, which is connected to the pockets in a fluid-conducting manner via radial channels, each of which is formed of a plurality of channel sections formed in adjacent laminations of the rotor lamination stack, is formed between the rotor shaft and the wall of the passage opening for supplying the casting compound from the annular channel to the pockets. A method is also provided for producing a rotor for an EC motor.
    Type: Application
    Filed: November 5, 2019
    Publication date: May 7, 2020
    Applicant: C. & E. Fein GmbH
    Inventors: Christoph MAIER, Martin ADAMCZYK, Thomas BURKHARDT