Abstract: Disclosed herein is a composition comprising at least one polymyxin or a salt thereof represented by formula (I) wherein R1 is an aliphatic linear or branched C6-C10 acyl group, or (I?) R5 is —CH(CH3)2, —CH2CH(CH3)2, —CH(CH3)CH2CH3, or —CH2C6H5; R6 is —CH(CH3)2, —CH2CH(CH3)2, or —CH(CH3)CH2CH3; each of R2, R3, R4, R7 and R8 is either —(CH2)xCH2NH2 or —(CH2)xCH2N(CH2SO3M)2; wherein x is 0 or 1; wherein M is a monovalent cation; and wherein at least three of R2, R3, R4, R7 and R8 are —(CH2)xCH2N(CH2SO3M)2.

Abstract: The present invention concerns 2-amino-3-methyl-hex-5-enoic acid, its use for the production of peptides such as bacitracins and a method for producing it.

Abstract: The present invention concerns 2-amino-3-mmethyl-hex-5-enoic acid, its use for the production of peptides such as bacitracins and a method for producing it.

Abstract: Disclosed herein is a composition comprising at least one polymyxin or a salt thereof represented by formula (I) wherein R1 is an aliphatic linear or branched C6-C10 acyl group, or (I?) R5 is —CH(CH3)2, —CH2CH(CH3)2, —CH(CH3)CH2CH3, or —CH2C6H5; R6 is —CH(CH3)2, —CH2CH(CH3)2, or —CH(CH3)CH2CH3; each of R2, R3, R4, R7 and R8 is either —(CH2)XCH2NH2 or —(CH2)xCH2N(CH2SO3M)2; wherein x is 0 or 1; wherein M is a monovalent cation; and wherein at least three of R2, R3, R4, R7 and R are —(CH2)xCH2N(CH2SO3M)2.

Abstract: The present invention relates to a process for purifying lipopeptides. More particular, the invention provides an improved method for purifying daptomycin.

Abstract: The present invention concerns a method of detecting the antifungal cyclic hexapeptides Pneumocandin B0 and/or Pneumocandin C0 specific fragment is/are detected using MS in negative mode.

Abstract: The invention concerns new Bacitracin compounds containing methylene-isoleucine.

Abstract: The invention concerns new Bacitracin compounds containing methylene-isoleucine.

Abstract: The present invention concerns 2-amino-3-methyl-hex-5-enoic acid, its use for the production of peptides such as bacitracins and a method for producing it.

Abstract: The present invention concerns a method of detecting the antifungal cyclic hexapeptides Pneumocandin B0 and/or Pneumocandin C0 specific fragment is/are detected using MS in negative mode.

Abstract: The present invention relates to a process for purifying lipopeptides. More particular, the invention provides an improved method for purifying daptomycin.

Abstract: The present invention relates to a lipopolysaccharide moiety comprising a conserved triheptosyl inner-core moiety of lipopolysaccharide substantially free of variable outer core oligosaccharide chain extension, and to vaccines obtaines therefrom which are cross-reactive for Haemophilus influenzae strains. The invention also relates to defined mutations in the biosynthetic machinery for lipopolysaccharide (LPS;) expression in Haemophilus influenzae useful to obtain the abovementioned moiety. The invention also relates to using conjugates of the LPS from the mutant strains so obtained to elicit a heterologous immune response against a wide range of disease-causing H. influenzae strains. More specifically, the invention relates to vaccines for prevention of bacterial infections comprising core lipopolysaccharide of Haemophilus influenzae.

Abstract: The present invention relates to a lipopolysaccharide moiety comprising a conserved triheptosyl inner-core moiety of lipopolysaccharide substantially free of variable outer core oligosaccharide chain extension, and to vaccines obtaines therefrom which are cross-reactive for Haemophilus influenzae strains. The invention also relates to defined mutations in the biosynthetic machinery for lipopolysaccharide (LPS;) expression in Haemophilus influenzae useful to obtain the abovementioned moiety. The invention also relates to using conjugates of the LPS from the mutant strains so obtained to elicit a heterologous immune response against a wide range of disease-causing H. influenzae strains. More specifically, the invention relates to vaccines for prevention of bacterial infections comprising core lipopolysaccharide of Haemophilus influenzae.

Abstract: The present invention comprises an apparatus in a power plant having a combustion chamber for combustion of a fuel at overpressure, a turbine driven by generated combustion gases, a compressor driven by the turbine for compression of combustion air, a generator driven by the turbine and a gas conduit for transfer of combustion gases from the combustion chamber to the turbine, the apparatus including at least two start-up combustors located radially around the gas conduit, the start-up combustors being supplied upon the start-up with fuel and with combustion air from the compressor which in turn is rotated by the generator switched into motor operation. The start-up combustors deliver combustion gases to the turbine which, in turn, supplies power to the compressor.

Abstract: A method and a device for controlling the blade tip clearance in a rotating machine where the machine comprises a turbine part and a compressor part separate from the turbine part and the stator housing of the turbine part is formed with a stator cone. The invention is characterized in that one or more bladed turbine discs during a non-steady operation, such as start-up, stop and load changes, are moved out of the stator cone whereby the blade tip clearance is increased and that the turbine discs during continuous operation are moved into the stator cone such that the blade top clearance is reduced.

Abstract: A power plant utilizing combustion of fuel in a fluidized bed contains a particulate sulfur-absorbing material. A discharge device for bed material and ashes includes a crusher which breaks down the material so that it can be transported away or so that unconsumed absorbent in the bed material is exposed for reuse in the bed. The crusher has a stationary grinding portion and a rotating grinding portion receiving bed material. Scrapers selectively scrape off layers of material during rotation of the rotating grinding portion thus distributing the material around the periphery of the grinding portions.

Abstract: The bed depth in a power plant burning sulfur-containing fuel in a fluidized bed of material which constitutes a sulfur absorbent in a combustion chamber is controlled on the basis of plant power output. A plurality of sensors connected to the combustion chamber determine the existing bed depth. A bed material mill grinds material removed from the bed prior to returning it to the bed, the rate at which the mill operates being controlled by the extent to which the actual bed depth differs from the desired bed depth. The mill grinds some bed material to small enough size for it to be carried from the combustion chamber with the combustion gases.

Abstract: A plant for combustion of a particulate fuel in a fluidized bed in a combustion chamber has the fuel supplied into the bottom of the combustion chamber by means of a pneumatic transportation system via nozzles. Fuel for the plurality of nozzles is transported through a duct to a distributor and from there via individual conduits to the nozzles of the combustion chamber. These conduits include flow-inhibiting, pressure-drop generating means, by means of which a pressure drop is generated between the distributor and the combustion chamber. These pressure-drop inducing means influence the velocity of flow and hence the transport capacity of the transport gas so that a desired, normally uniform, distribution of fuel to the bed is secured.

Abstract: A gas turbine plant having an ignition combustion chamber for applying heated gas to heat the fluidized bed material to ignition temperature. In starting up the plant, a starter motor is employed to rotate a turbine and thereby to cause a compressor to produce compressed air. Liquid or gaseous fuel is applied to the ignition combustion chamber and is ignited within the chamber to heat compressed air from the compressor. The compressed air is passed through the fluidized bed combustor to heat the bed material up to ignition temperature. During the start-up operation, bed material in the fluidized bed combustor is reduced to reduce the pressure requirements for the heated compressed air.

Abstract: Combustion system for gas turbines and the like, comprising an outer shell connected to a source of pressurized air and surrounding a flame tube which comprises a combustion chamber and a mixing chamber defined within a double wall construction comprising an outer wall and an inner wall forming an annular cooling jacket axially surrounding the mixing chamber. A portion of the pressurized air is directed radially into the mixing chamber through a plurality of nozzles which are spaced about the cooling jacket, while another portion of the air is passed into said annular jacket through apertures in the outer wall alternating with and spaced a distance from said nozzles to produce a plurality of diverging high velocity peripheral streams which sweep and cool the walls of the jacket preliminary to being passed into the mixing chamber through apertures in the inner wall which are aligned with said nozzles.