Patents by Inventor Martin Marek

Martin Marek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COELENTERAZINE-UTILIZING LUCIFERASES WITH STABLE GLOW-TYPE LIGHT EMISSION AND METHODS OF PRODUCING AND USING THEREOF
    Publication number: 20240279622
    Abstract: The present invention includes polynucleotides that encode novel coelenterazine-utilizing luciferases as well as fragments and mutants thereof having at least 85% sequence identity. The sequences were generated by ancestral sequence reconstruction combined with single-point mutations and transplantation of important regions from the related Renilla reniformis luciferase protein. The luciferases according to the present invention exhibit modulated properties including at least one of: increased bioluminescence emission stability and half-life; increased affinity towards substrate over the product (suppressed product inhibition); increased thermostability; increased glow-type effectivity; and modulated emission maximum.
    Type: Application
    Filed: August 16, 2022
    Publication date: August 22, 2024
    Applicants: MASARYKOVA UNIVERZITA, FAKULTINI NEMOCNICE U SV. ANNY V BRNE
    Inventors: Martin Toul, Andrea Smith, Martin Marek, Jose Gaspar Rangel Pamplona Pizarro Pinto, Joan Planas-Inglesias, Daniel Pluskal, Michal Vasina, David Bednar, Zbynek Prokop, Jiri Damborsky
  • Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions
    Patent number: 11236307
    Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with a reduced number of or without contaminating baculoviral virions.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: February 1, 2022
    Assignee: GENETHON
    Inventors: Otto-Wilhelm Merten, Martin Marek, Monique Van Oers
  • BACULOVIRUS-BASED PRODUCTION OF BIOPHARMACEUTICALS FREE OF CONTAMINATING BACULOVIRAL VIRIONS
    Publication number: 20200002683
    Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with a reduced number of or without contaminating baculoviral virions.
    Type: Application
    Filed: August 27, 2019
    Publication date: January 2, 2020
    Inventors: OTTO-WILHELM MERTEN, MARTIN MAREK, MONIQUE VAN OERS
  • Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions
    Patent number: 10428315
    Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with a reduced number of or without contaminating baculoviral virions.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: October 1, 2019
    Assignee: GENETHON
    Inventors: Otto-Wilhelm Merten, Martin Marek, Monique Van Oers
  • BACULOVIRUS-BASED PRODUCTION OF BIOPHARMACEUTICALS FREE OF CONTAMINATING BACULOVIRAL VIRIONS
    Publication number: 20180127728
    Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with a reduced number of or without contaminating baculoviral virions.
    Type: Application
    Filed: December 14, 2017
    Publication date: May 10, 2018
    Inventors: OTTO-WILHELM MERTEN, MARTIN MAREK, MONIQUE VAN OERS
  • Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions
    Patent number: 9862934
    Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with a reduced number of or without contaminating baculoviral virions.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: January 9, 2018
    Assignee: GENETHON
    Inventors: Otto-Wilhelm Merten, Martin Marek, Monique Van Oers
  • BACULOVIRUS-BASED PRODUCTION OF BIOPHARMACEUTICALS FREE OF CONTAMINATING BACULOVIRAL VIRIONS
    Publication number: 20150252335
    Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with a reduced number of or without contaminating baculoviral virions.
    Type: Application
    Filed: March 27, 2015
    Publication date: September 10, 2015
    Inventors: OTTO-WILHELM MERTEN, MARTIN MAREK, MONIQUE VAN OERS
  • Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions
    Patent number: 8993317
    Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with reduced or no contaminating baculoviral virions.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: March 31, 2015
    Assignee: Genethon
    Inventors: Otto-Wilhelm Merten, Martin Marek, Monique Van Oers
  • BACULOVIRUS-BASED PRODUCTION OF BIOPHARMACEUTICALS FREE OF CONTAMINATING BACULOVIRAL VIRIONS
    Publication number: 20120149010
    Abstract: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with reduced or no contaminating baculoviral virions.
    Type: Application
    Filed: August 5, 2010
    Publication date: June 14, 2012
    Applicant: Genethon
    Inventors: Otto-Wilhelm Merten, Martin Marek, Monique Van Oers