Abstract: The present invention concerns antigen binding proteins specifically binding melanoma associated antigen A (MAGE-A) protein-derived antigens. The invention in particular provides antigen binding proteins which specifically bind to the MAGE-A antigenic peptide comprising or consisting of SEQ ID NO: 1 in a complex with a major histocombatibility (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said MAGE-A peptide/MHC complex. The antigen binding proteins of the invention are of use for the diagnosis, treatment and prevention of MAGE-A expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: A hybrid transmission for a vehicle includes a transmission input shaft extending in a transverse direction, at least one countershaft arranged parallel to the transmission input shaft, a clutch device arranged coaxially with respect to the transmission input shaft and which has at least one clutch, and a differential having a differential input gear. A rotational axis of the differential input gear is arranged parallel to the transmission input shaft. The transmission also includes an electric machine having a rotor with a rotor rotational axis arranged parallel to the transmission input shaft and a transmission control device. As viewed in a longitudinal direction perpendicular to the transverse direction, the differential input gear, the transmission input shaft, and a transmission controller including the transmission control device are arranged in succession in the sequence specified.

Abstract: The present invention concerns antigen binding proteins directed against PRAME protein-derived antigens. The invention in particular provides antigen binding proteins which are specific for the tumor expressed antigen PRAME, wherein the tumor antigen comprises or consists of SEQ ID NO: 50 and is in a complex with a major histocompatibility complex (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said PRAME peptide. The antigen binding proteins of the invention are for use in the diagnosis, treatment and prevention of PRAME expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising said nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: The present invention pertains to antigen recognizing constructs against COL6A3 antigens. The invention in particular provides novel engineered T cell receptor (TCR) based molecules which are selective and specific for the tumor expressing antigen COL6A3. The TCR of the invention, and COL6A3 antigen binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of COL6A3 expressing cancerous diseases. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.

Abstract: A hybrid transmission for a vehicle includes a transmission input shaft extending in a transverse direction, at least one countershaft arranged parallel to the transmission input shaft, a clutch device arranged coaxially with respect to the transmission input shaft and which has at least one clutch, and a differential having a differential input gear. A rotational axis of the differential input gear is arranged parallel to the transmission input shaft. The transmission also includes an electric machine having a rotor with a rotor rotational axis arranged parallel to the transmission input shaft and a transmission control device. As viewed in a longitudinal direction perpendicular to the transverse direction, the differential input gear, the transmission input shaft, and a transmission controller including the transmission control device are arranged in succession in the sequence specified.

Abstract: A hybrid transmission for a vehicle includes a transmission input shaft extending in a transverse direction, at least one countershaft arranged parallel to the transmission input shaft, a clutch device arranged coaxially with respect to the transmission input shaft and which has at least one clutch, and a differential having a differential input gear. A rotational axis of the differential input gear is arranged parallel to the transmission input shaft. The transmission also includes an electric machine having a rotor with a rotor rotational axis arranged parallel to the transmission input shaft and a transmission control device. As viewed in a longitudinal direction perpendicular to the transverse direction, the differential input gear, the transmission input shaft, and a transmission controller including the transmission control device are arranged in succession in the sequence specified.

Abstract: A method for forming a wellbore in an earth formation includes positioning a drill string in a wellbore; the drill string including a bottom hole assembly (BHA) that includes a steering unit, one or more sensors responsive to one or more formation properties, and one or more sensors responsive to the current orientation of the BHA in a wellbore. The method also includes receiving information from the BHA related to the formation properties and information related to a current orientation of the BHA in the wellbore and processing the information using computing device that is either a programmable optical computing device or a quantum computing device. The computing device calculates the position of formation features with respect to current wellbore position in real time and compare the current position to a prescribed path.

Abstract: A method for forming a wellbore in an earth formation includes positioning a drill string in a wellbore; the drill string including a bottom hole assembly (BHA) that includes a steering unit, one or more sensors responsive to one or more formation properties, and one or more sensors responsive to the current orientation of the BHA in a wellbore. The method also includes receiving information from the BHA related to the formation properties and information related to a current orientation of the BHA in the wellbore and processing the information using computing device that is either a programmable optical computing device or a quantum computing device. The computing device calculates the position of formation features with respect to current wellbore position in real time and compare the current position to a prescribed path.

Abstract: An embodiment of a system for estimating a parameter of an earth formation includes at least one formation parameter sensor disposed at a first downhole component and configured to measure a parameter of an earth formation to generate formation parameter data, and one or more processors in operable communication with the at least one formation parameter sensor. The one or more processors are configured to perform: generating a mechanics model of at least one of the first downhole component and a second downhole component, the mechanics model based on geometrical data representing at least one of the first downhole component and the second downhole component; estimating a misalignment of the at least one formation parameter sensor by using the mechanics model; and correcting the formation parameter data based on the misalignment.

Abstract: The invention relates to a disk blank (18) for producing commutator bars of a disk commutator as well as to a commutator bar and a disk commutator realized as having such commutator bars, said disk blank (18) being realized as a multi-layered body and having a carbon mold body having a continuous first layer and having a contact arrangement which forms a second layer disrupted by transition areas in such a manner that the transition areas do not comprise any contact material.

Abstract: A method for inverting dielectric logging tool measurement data to estimate an electrical characteristic of an earth formation includes: receiving measurement data from the logging tool having a transmitter antenna and receiver antennas spaced known distances from the transmitter antenna; establishing an equation relating magnetic field measurements made by the receiver antennas to the distances and a wave vector; establishing an error equation that quantifies a difference between the magnetic field measurements made by the receiver antennas to magnetic field measurements made by the receiver antennas that would be obtained with an estimated formation electrical characteristic; calculating an error using the error equation for an initial estimated value of the wave vector that comprises a term having a first number multiplied times a second number of radians to provide a plurality of calculated errors; and determining a minimum error from the plurality of calculated errors to estimate the electrical character

Abstract: The invention relates to the use of a carbon composite material for manufacturing electrical contact elements of a fuel pump operated in a fuel environment, the contact elements being designed as carbon molds, wherein, in addition to carbon, the carbon composite material comprises a thermosetting or thermoplastic binder and a metal content that amounts to more than 0.5% and less than 25% of the total mass of the carbon composite material.

Abstract: A device for grilling and cooking food. The device should be easy to produce and safe to handle. The device includes a pan made of steel with lateral walls and a heating surface for cooking food, which heating surface is disposed largely horizontal, optionally with a slight incline inwards, and which is connected to the lateral walls. The pan includes a grate-like intermediate base disposed parallel to the heating surface, with the heating surface disposed at least along one of the lateral walls of the pan.

Abstract: A method for forming a wellbore in an earth formation includes positioning a drill string in a wellbore; the drill string including a bottom hole assembly (BHA) that includes a steering unit, one or more sensors responsive to one or more formation properties, and one or more sensors responsive to the current orientation of the BHA in a wellbore. The method also includes receiving information from the BHA related to the formation properties and information related to a current orientation of the BHA in the wellbore and processing the information using computing device that is either a programmable optical computing device or a quantum computing device. The computing device calculates the position of formation features with respect to current wellbore position in real time and compare the current position to a prescribed path.

Abstract: An embodiment of a system for estimating a parameter of an earth formation includes at least one formation parameter sensor disposed at a first downhole component and configured to measure a parameter of an earth formation to generate formation parameter data, and one or more processors in operable communication with the at least one formation parameter sensor. The one or more processors are configured to perform: generating a mechanics model of at least one of the first downhole component and a second downhole component, the mechanics model based on geometrical data representing at least one of the first downhole component and the second downhole component; estimating a misalignment of the at least one formation parameter sensor by using the mechanics model; and correcting the formation parameter data based on the misalignment.

Abstract: A device for grilling and cooking food. The device should be easy to produce and safe to handle. The device includes a pan made of steel with lateral walls and a heating surface for cooking food, which heating surface is disposed largely horizontal, optionally with a slight incline inwards, and which is connected to the lateral walls. The pan includes a grate-like intermediate base disposed parallel to the heating surface, with the heating surface disposed at least along one of the lateral walls of the pan.

Abstract: A preferably air-tight and liquid-tight collapsible container comprises a container body (5) formed of a sheet material, said sheet material having two thermoplastic surfaces (2, 3), said sheet material comprising a preferably fluid-tight carrier foil (1) provided at least on and preferably on both sides (2, 3), with a thermoplastic semi-rigid or rigid layer material, preferably a polyester based material said sheet material being folded to a container-like body and sealed in the overlapping edge regions (6, 7) to form a container-like body, said container-like body being coated with a sheathing (9) of elastomeric thermoplastic material of the same kind or type as the foil material to form a container body (5), said container body (5) being provided at one open end (5a) with a container head formed from thermoplastic material of the same kind or type as the foil material.