Abstract: Present invention concerns the use of Cathepsin H. Other aspects of the invention concern methods for screening pharmaceuticals, for diagnosing pain susceptibility and for the treatment of pain.

Abstract: The present invention relates to nucleic acid arrays used to detect genes which are up or down regulated following a pain stimulus in a mammal. It further relates to the use of GPR151 in methods to detect pain or evaluate the effect of a compound on the level of pain in a mammal. Other aspects of the invention concern a method for screening pharmaceuticals, methods for the treatment of pain and a pharmaceutical composition comprising a GPR151 modulator for the treatment of pain.

Abstract: Use of PAM or functional fragments or derivatives thereof for the preparation of pharmaceutical compounds.

Abstract: Present invention concerns the use of Cathepsin C. Other aspects of the invention concern methods for screening pharmaceuticals, for diagnosing pain susceptibility and for the treatment of pain.

Abstract: The present invention relates to the use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides of the formula I, wherein A and R1 to R6 have the meanings indicated in the claims, for treating pain and for manufacturing a medicament for the treatment of pain.

Abstract: The invention relates to a condensation product obtainable by reaction of a1) at least one bicyclic or polycyclic aromatic or heteroaromatic, where the bicyclic or polycyclic aromatic or heteroaromatic is substituted by at least one carboxyl group (—COOH), and where the carboxyl group can be present in salt form, a2) at least one carbonyl compound, a3) if appropriate at least one sulfonating agent, a4) at least one urea derivative, and a5) if appropriate at least one further aromatic or heteroaromatic, or a physiologically tolerable salt thereof.

Abstract: Methods for alleviating pain comprising administering to a subject sphingosine-1-phosphate, functional fragments and derivatives thereof, and other compounds, and assays for identifying such compounds.

Abstract: Methods for alleviating pain comprising administering to a subject sphingosine-1-phosphate, functional fragments and derivatives thereof, and other compounds, and assays for identifying such compounds.

Abstract: Nanoparticles, the particle matrix of which is based on at least one protein and has at least one active agent embedded therein and methods of producing the nanoparticles with at least one active agent embedded in the protein matrix are disclosed. The use of the nanoparticles for the treatment of tumours, in particular for the treatment of tumours which are resistant to chemical medicaments is also disclosed.

Abstract: The present invention relates to a method for the prophylaxis or treatment of pain using compounds of formula I, in which R, R2, R3, R4 and R5 have the meanings indicated in the specification.

Abstract: The present invention relates to the use of I?B-kinase Inhibitors and methods for the prophylaxis and therapy for treating pain comprising administering such compounds.

Abstract: Peptides having bradykinin-antagonistic action are suitable for the production of pharmaceuticals for the prophylaxis and therapy of diseases in whose course an increased activity of matrix metalloproteinases is involved. These include diseases such as degenerative joint diseases, for example osteoarthrosis, spondylosis and chondroporosis after joint trauma or relatively long immobilization of a joint after meniscus or patella injuries or torn ligaments. The invention therefore relates to the use of a compound of the formula I, A-B-X-E-F-K-(D)-TIC-G-M-F?-I??(I) for the production of pharmaceuticals for the treatment of degenerative joint diseases, wherein A, B, X, E, F, K, (D)-TIC, G, M, F? and I are as defined herein.

Abstract: The present invention relates to the use of I?B-kinase Inhibitors and methods for the prophylaxis and therapy for treating pain comprising administering such compounds.

Abstract: The invention relates to a sole for a footwear item. The invention essentially comprises a sock lining (1), an insole (2) and an outsole (3) as well as a shock-absorbing device (4). The inventive sole is characterised in that the aforementioned shock-absorbing device is an elastically-deformable element or insert (4) which is inserted into the sole in the form of a moulded body (4) comprising mutually-spaced tubular pieces (4?) having one closed end and one open end which is connected to a common base (4?).

Abstract: The invention relates to a sole for a footwear item. The invention essentially comprises a sock lining (1), an insole (2) and an outsole (3) as well as a shock-absorbing device (4).

Abstract: The invention relates to a reference mark, a method for recognizing reference marks and a method for object measuring. According to the invention, the object is fitted with coded reference marks. Said marks are automatically recognized and decoded by the inventive method for reference mark recognition, whereupon a three-dimensional representation of the object is realized. According to the invention, the method compensates automatically for geometrical and radiometric interferences and generates at least one quality measurement to evaluate the quality of recognition and decoding. The invention particularly enables fast recognition and decoding of large numbers of reference marks and fast measuring of objects.

Abstract: Use of PAM or functional fragments or derivatives thereof for the preparation of pharmaceutical compounds.

Abstract: Methods for alleviating pain comprising administering to a subject sphingosine-1-phosphate, functional fragments and derivatives thereof, and other compounds, and assays for identifying such compounds.

Abstract: The invention relates to the use of calpain or functional fragments or derivatives thereof for the preparation of pharmaceutical compounds that modulate pain, and the use of calpain or functional fragments of derivatives thereof for identifying such compounds, and a method of screening pharmaceuticals useful for modulating and/or preventing pain.

Abstract: The present invention relates to a method for the prophylaxis or treatment of pain using compounds of formula I, 1