Abstract: Provided herein are APP RNAi agents and compositions comprising an APP RNAi agent. Also provided herein are methods of using the APP RNAi agents or compositions comprising an APP RNAi agent in reducing APP expression and/or treating APP associated neurological diseases.

Abstract: A turbine engine includes, in a serial flow relationship, an axially oriented compressor, a combustion section, a turbine section, and an exhaust section. An air flowpath extends from an inlet duct to the exhaust section such that the compressor, combustion section, turbine, and the exhaust section are in fluid communication. The inlet duct is positioned upstream of the compressor and defines an inlet portion of the air flowpath. The inlet duct is generally radially oriented. A variable inlet guide vane extends at least partially through the inlet duct.

Abstract: A separate heat absorbing mass is secured in co-planar abutment with a bimetal strip controlling a fireplace damper to absorb heat from the flue gases. The mass transfers heat to the bimetal strip during the OFF cycle thereby delaying the opening of the damper and increasing the heat retention and efficiency of the fireplace.

Abstract: An apparatus and method for mounting a turbine engine to an aircraft can include an engine core for the turbine engine including a compressor section, a combustor section, and a turbine section in flow arrangement. At least one strut couples to the engine core about a single mount plane. A structural wall at least partially defining a mainstream flow path couples to the at least one strut and passes through the compressor section and the turbine section.

Abstract: An apparatus and method for mounting a turbine engine to an aircraft can include an engine core for the turbine engine including a compressor section, a combustor section, and a turbine section in flow arrangement. At least one strut couples to the engine core about a single mount plane. A structural wall at least partially defining a mainstream flow path couples to the at least one strut and passes through the compressor section and the turbine section.

Abstract: A separate heat absorbing mass is secured in co-planar abutment with a bimetal strip controlling a fireplace damper to absorb heat from the flue gases. The mass transfers heat to the bimetal strip during the OFF cycle thereby delaying the opening of the damper and increasing the heat retention and efficiency of the fireplace.

Abstract: A damper mechanism restricting combustion and exhaust air flow in response to temperature changes in a direct vent sealed combustion gas fireplace is provided. The mechanism allows the fireplace to have unrestricted air flow when the fireplace is not on and to restrict the air flow when the fireplace is on. A bi-metallic temperature responsive element is used to move a restrictor element to restrict air flow allowing maximum air displacement during cold ignition and enhancing operating efficiency when the fireplace is on.

Abstract: A turbine engine includes, in a serial flow relationship, an axially oriented compressor, a combustion section, a turbine section, and an exhaust section. An air flowpath extends from an inlet duct to the exhaust section such that the compressor, combustion section, turbine, and the exhaust section are in fluid communication. The inlet duct is positioned upstream of the compressor and defines an inlet portion of the air flowpath. The inlet duct is generally radially oriented. A variable inlet guide vane extends at least partially through the inlet duct.

Abstract: A gas turbine engine includes a compressor section and turbine section. The gas turbine engine of the present disclosure is a relatively small gas turbine engine, configured to generate less than 2,000 horsepower during peak operations. The compressor section defines an overall compressor ratio of at least 15:1 in order to increase in overall efficiency of the gas turbine engine.

Abstract: A computer-implemented technique for generating a visual display illustrating the flow of user content in a social network is described. The technique can include determining a user content associated with a plurality of users. The technique can further include generating a visual display that includes a region for each user of the plurality of users. The technique can also include generating arranging the regions in the visual display according to a set of layout rules, and aligning a directional indicator in the visual display. The technique can include providing the visual display to a user via a display.

Abstract: A method and computer program product for generating a data visualization based, at least in part, upon a data set. A first user is allowed to add an annotation to at least a portion of the data visualization. A determination is made concerning whether the annotation is associatable with any portion of the data set.

Abstract: A computer-implemented technique for generating a visual display illustrating the flow of user content in a social network is described. The technique can include determining a user content associated with a plurality of users. The technique can further include generating a visual display that includes a region for each user of the plurality of users. The technique can also include generating arranging the regions in the visual display according to a set of layout rules, and aligning a directional indicator in the visual display. The technique can include providing the visual display to a user via a display.

Abstract: A computer-implemented technique for generating a visual display illustrating the flow of user content in a social network is described. The technique can include determining a user content associated with a plurality of users. The technique can further include generating a visual display that includes a region for each user of the plurality of users. The technique can also include generating arranging the regions in the visual display according to a set of layout rules, and aligning a directional indicator in the visual display. The technique can include providing the visual display to a user via a display.

Abstract: Whilst partaking in a traditional electronic questionnaire survey, responses given by any one respondent are almost always influenced by that person's emotional state due to the survey format. This emotional content skews the results thus obtained making them inaccurate, so that statistical methods become necessary to interpret the results. Such a statistical analyses requires not only a minimum sample size but also to be interpreted, which can also lead to false, non repeatable results. However, by structuring the system and method of the electronic questionnaire survey in accordance with a strict set of guidelines, it is possible to measure a respondent's views on any subject matter both emotionally and rationally, together with the respondent's level of conviction. By comparing the emotional responses with the rational responses, a truly quantifiable and repeatable measure of respondent satisfaction towards the subject matter can be achieved, which also allows benchmarking as an added benefit.

Abstract: A computer-implemented technique for generating a visual display illustrating the flow of user content in a social network is described. The technique can include determining a user content associated with a plurality of users. The technique can further include generating a visual display that includes a region for each user of the plurality of users. The technique can also include generating arranging the regions in the visual display according to a set of layout rules, and aligning a directional indicator in the visual display. The technique can include providing the visual display to a user via a display.

Abstract: Described is a method for visualization of attributes of workflow weblogs. A group of workflow weblogs is searched to find weblogs that have an attribute that satisfies a search condition. The group of workflow weblogs can include instantiations of a single workflow. Attributes are displayed for each of the weblogs found by the search. An attribute is displayed using a modified graphical parameter if the attribute satisfies a predefined condition for the attribute type. The modified graphical parameter can include modified text or a modified graphical structure.

Abstract: The invention provides an insert assembly to convert an existing fireplace hearth into a gas burning fireplace and a method for installing the insert assembly while conveying the appearance of a wood burning fireplace. The insert assembly comprises legs removably attachable to the base of the firebox for allowing the insert to be installed higher into the hearth. The inner walls of the firebox are colored so as to camouflage the structure of the assembly in the hearth and a decorative fender mimics a wood burning grill. Where the insert includes a heat exchanger, a guide plate is provided at the top of the insert to ensure that air exiting the heat exchange outlet at the top of the insert is directed into the room.

Abstract: A damper mechanism restricting combustion and exhaust air flow in response to temperature changes in a direct vent sealed combustion gas fireplace is provided. The mechanism allows the fireplace to have unrestricted air flow when the fireplace is not on and to restrict the air flow when the fireplace is on. A bi-metallic temperature responsive element is used to move a restrictor element to restrict air flow allowing maximum air displacement during cold ignition and enhancing operating efficiency when the fireplace is on.

Abstract: The visibility of a treemap is improved by offsetting the area of a parent node relative to a bounding box containing all of its child nodes while constructing the treemap, so that a part of the bounding box lies outside the area of the parent node, and the area of each child node in the bounding box is located entirely or partially within the area of the parent node. The present invention highlights the parent-child relationships in the treemap with a cascading effect to make the structural information therein more apparent and easier to recognize.

Abstract: A method and computer program product for generating a data visualization based, at least in part, upon a data set. A first user is allowed to add an annotation to at least a portion of the data visualization. A determination is made concerning whether the annotation is associatable with any portion of the data set.