Patents by Inventor Martin Missbach
Martin Missbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6353017Abstract: N-terminal substituted dipeptide nitriles as defined are useful as inhibitors of cysteine cathepsins, e.g. cathepsins B, K, L and S, and can be used for the treatment of cysteine cathepsin dependent diseases and conditions, including inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis, tumors (especially tumor invasion and tumor metastasis), coronary disease, atherosclerosis (including atherosclerotic plaque rupture and destabilization). Particular dipeptide nitriles are compounds of formula I, or physiologically-acceptable and -cleavable esters or a salts thereof wherein: the symbols are as defined. In particular it has been found that by appropriate choice of groups R, R2, R3, R4, R5, X1, Y and L, the relative selectivity of the compounds as inhibitors of the various cysteine cathepsin types, e.g. cathepsins B, K, L and S may be altered, e.g. to obtain inhibitors which selectively inhibit a particular cathepsin type or combination of cathepsin types.Type: GrantFiled: August 22, 2000Date of Patent: March 5, 2002Assignee: Novartis AGInventors: Eva Altmann, Claudia Betschart, Keigo Gohda, Miyuki Horiuchi, Rene Lattmann, Martin Missbach, Junichi Sakaki, Michihiro Takai, Naoki Teno, Scott Douglas Cowen, Paul David Greenspan, Leslie Wighton McQuire, Ruben Alberto Tommasi, John Henry van Duzer
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Publication number: 20010016207Abstract: Dipeptide nitrile Cathepsin K inhibitors of formula I, and pharmaceutically acceptable salts or esters thereof 1Type: ApplicationFiled: February 7, 2001Publication date: August 23, 2001Inventor: Martin Missbach
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Patent number: 6218359Abstract: The current invention concerns the use of a receptor from the RZR/ROR receptor family or of a functional fragment thereof in a test of a compound for anti-autoimmune, anti-arthritic, anti-tumor, melatonin-like and/or melatonin-antagonistic activity and the production of a receptor ligand complex comprising said receptor or a functional fragment thereof and a ligand of said receptor. Described is also a method for testing compounds for said activity (screening for ligands) and the active compounds identified therewith.Type: GrantFiled: June 29, 1999Date of Patent: April 17, 2001Assignee: Novartis CorporationInventors: Irmgard Wiesenberg, Martin Missbach
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Patent number: 5958683Abstract: The current invention concerns the use of a receptor from the RZR/ROR receptor family or a functional fragment thereof in a test of a compound for anti-autoimmune, anti-arthritic, anti-tumor, melatonin-like and or melatonin-antagonistic activity and the production of a receptor ligand complex comprising the receptor or a functional fragment thereof and a ligand of the receptor. Also described is a method for testing compounds for said activity (screening for ligands) and the active compounds identified therewith.Type: GrantFiled: August 22, 1996Date of Patent: September 28, 1999Assignee: Novartis CorporationInventors: Irmgard Wiesenberg, Martin Missbach
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Patent number: 5869485Abstract: The invention relates to the use of the compounds mentioned below in the therapeutic treatment of tumor diseases and other proliferative diseases, such as psoriasis, and to novel compounds of that type. The compounds are compounds of formula I ##STR1## wherein n is from 0 to 5 and, when n is not 0,R is one or more substituents selected from halogen, alkyl, trifluoromethyl and alkoxy; andR.sub.1 and R.sub.2 are each independently of the other alkyl, or phenyl that is unsubstituted or substituted by halogen, trifluoromethyl, alkyl or by alkoxy, it also being possible for one of the two radicals R.sub.1 and R.sub.2 to be hydrogen, or R1 and R2 together form an alkylene chain having from 2 to 5 carbon atoms that is unsubstituted or substituted by alkyl; or salts thereof. Compounds of formula I inhibit protein kinases, for example the tyrosine protein kinase of the receptor for the epidermal growth factor, EGF.Type: GrantFiled: March 19, 1997Date of Patent: February 9, 1999Assignee: Novartis Finance Corp.Inventor: Martin Missbach
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Patent number: 5641776Abstract: The present invention relates to novel substituted thiosemicarbazone derivatives of formula (I) wherein R.sub.1 is lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, or aryl-lower alkyl, R.sub.2 is hydrogen, lower alkyl, aryl, aryl-lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, unsaturated or saturated heterocyclyl-lower alkyl, lower alkoxycarbonyl-lower alkyl or the group --C(.dbd.O)--R.sub.3, wherein R.sub.3 is lower alkyl, aryl, aryl-lower alkyl, aryl-lower alkenyl, heteroaryl (betaryl), aryloxy, aryl-lower alkoxy or lower alk-2-en-1-yloxy, and the salts thereof, to a process for the preparation of said compounds, to pharmaceutical compositions containing them, and to the use thereof as medicaments.Type: GrantFiled: July 25, 1995Date of Patent: June 24, 1997Assignee: Ciba-Geigy CorporationInventor: Martin Missbach
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Patent number: 5633253Abstract: The present invention relates to novel substituted thiosemicarbazonic acid esters of formula I ##STR1## wherein R.sub.1 is lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, or aryl-lower alkyl, R.sub.2 is hydrogen, lower alkyl, aryl, aryl-lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, unsaturated or saturated heterocyclyl-lower alkyl, lower alkoxycarbonyl-lower alkyl or the group --C(.dbd.O)-R.sub.3, wherein R.sub.3 is lower alkyl, aryl, aryl-lower alkyl, aryl-lower alkenyl, heteroaryl (hetaryl), aryloxy, aryl-lower alkoxy or lower alk-2-en-1-yloxy, and R.sub.4 is lower alkyl, lower alkoxy, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, aryl-lower alkyl, aryl-lower alkenyl, or also lower alkoxycarbonyl-lower alkyl, and the salts thereof, to a process for the preparation of said compounds, to pharmaceutical compositions containing them, and to the use thereof as medicaments.Type: GrantFiled: July 25, 1995Date of Patent: May 27, 1997Assignee: Ciby-Geigy CorporationInventor: Martin Missbach
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Patent number: 5627180Abstract: The present invention relates to novel substituted thiosemicarbazonethiones containing 6-ring members of formula I ##STR1## wherein R.sub.1 is lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, or aryl-lower alkyl, R.sub.2 is hydrogen, lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, aryl, aryl-lower alkyl, unsaturated or saturated heterocyclyl-lower alkyl, lower alkoxycarbonyl-lower alkyl or a group --C(.dbd.O)-R.sub.3 or --C(.dbd.S)-R.sub.3, wherein R.sub.3 is lower alkyl, aryl, aryl-lower alkyl, aryl-lower alkenyl, heteroaryl (hetaryl), aryloxy, aryl-lower alkoxy or lower alk-2-en-1-yloxy, and the salts thereof, to a process for the preparation of said compounds, to pharmaceutical compositions containing them, and to the use thereof as medicaments.Type: GrantFiled: July 25, 1995Date of Patent: May 6, 1997Assignee: Ciba-Geigy CorporationInventor: Martin Missbach
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Patent number: 5491158Abstract: The invention relates to novel thiosemicarbazonethiones of formula (I) wherein R.sub.1 is lower alkyl, lower alk-2-en-1-yl or also lower alk-2-yn-1-yl, R.sub.2 and R.sub.3 are each independently of the other hydrogen or lower alkyl or, taken together, are lower alkylidene, R.sub.4 is hydrogen, lower alkyl, lower alkoxy, aryl or aryl-lower alkyl, R.sub.5 is lower alkyl, aryl, aryl-lower alkyl, unsaturated or saturated heterocyclyl-lower alkyl, or is also lower alkyloxycarbonyl-lower alkyl, and the salts thereof, to a process for the preparation of these compounds, to pharmaceutical compositions containing them, and to the use thereof as medicaments.Type: GrantFiled: May 16, 1994Date of Patent: February 13, 1996Assignee: Ciba-Geigy CorporationInventor: Martin Missbach
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Patent number: 5399576Abstract: Novel thiazoles of formula I ##STR1## wherein R.sub.1 and R.sub.4 are lower alkyl, lower alk-2-en-1-yl or lower alk-2-yn-1-yl,R.sub.2 and R.sub.3 are each independently of the other hydrogen or lower alkyl or together form lower alkylidene, andR.sub.5 and R.sub.6 are each hydrogen or lower alkyl or together form oxo, andR.sub.5 ' and R.sub.6 ' have the same definitions as R.sub.5 and R.sub.6,with the proviso that at least one of the substituent pairs R.sub.5 and R.sub.6 or R.sub.5 ' and R.sub.6 ' together form oxo, and salts thereof, processes for the preparation of the said compounds, pharmaceutical compositions comprising them and the use thereof as medicinal active ingredients.Type: GrantFiled: February 25, 1994Date of Patent: March 21, 1995Assignee: Ciba-Geigy CorporationInventor: Martin Missbach
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Patent number: 5378719Abstract: Novel imidazoles of formula I ##STR1## wherein R.sub.1 and R.sub.4 are lower alkyl, lower alk-2-en-1-yl or lower alk-2-yn-1-yl,R.sub.2 and R.sub.3 are each independently of the other hydrogen or lower alkyl or together form lower alkylidene, andR.sub.5 and R.sub.6 are each hydrogen or lower alkyl or together form oxo, andR.sub.5 ' and R.sub.6 ' have the same definitions as R.sub.5 and R.sub.6,with the proviso that at least one of the substituent pairs R.sub.5 and R.sub.6 or R.sub.5 ' and R.sub.6 ' together form oxo, and salts thereof, processes for the preparation of the said compounds, pharmaceutical compositions comprising them and the use thereof as medicinal active ingredients.Type: GrantFiled: February 15, 1994Date of Patent: January 3, 1995Assignee: Ciba-Geigy CorporationInventor: Martin Missbach
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Patent number: 5344842Abstract: The invention relates to novel thiosemicarbazones of formula I ##STR1## wherein R.sub.1 is lower alkyl, lower alk-2-en-1-yl or lower alk-2-yn-1-yl,R.sub.2 and R.sub.3 independently of one another are hydrogen or lower alkyl, or R.sub.2 and R.sub.3 together are lower alkylidene,R.sub.4 is hydrogen, lower alkyl, lower alkoxy, aryl or aryl-lower alkyl, or the group --C(.dbd.O)--R.sub.6 wherein R.sub.6 is lower alkyl, aryl, heteroaryl, aryloxy, aryl-lower alkoxy or lower alk-2-en-1-yloxy,R.sub.5 is aryl, aryl-lower alkyl, unsaturated or saturated heterocyclyl-lower alkyl, lower alkoxycarbonyl-lower alkyl or the group --C(.dbd.O)--R.sub.7 wherein R.sub.7 is lower alkyl, aryl, aryl-lower alkyl, aryl-lower alkenyl, heteroaryl, aryloxy, aryl-lower alkoxy or lower alk-2-en-1-yloxy, or, when R.sub.4 is other than hydrogen, R.sub.Type: GrantFiled: May 24, 1993Date of Patent: September 6, 1994Assignee: Ciba-Geigy CorporationInventor: Martin Missbach
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Patent number: 5338746Abstract: The invention relates to novel thiosemicarbazonic acid esters of formula I ##STR1## wherein R.sub.1 and R.sub.5 are lower alkyl, lower alk-2-en-1-yl or lower alk-2-yn-l-yl,R.sub.2 and R.sub.3 independently of one another are hydrogen or lower alkyl or together are lower alkylidene, andR.sub.4 is lower alkyl, lower alkoxy, lower alk-2-en-1-yl, lower alk-2-yn-l-yl, aryl-lower alkyl, aryl-lower alkenyl or lower alkoxycarbonyl-lower alkyl, and to the salts and tautomeric compounds and double-bond isomers thereof, to processes for the preparation of the said compounds, to pharmaceutical compositions comprising them and to their use in the treatment of rheumatoid type diseases.Type: GrantFiled: September 15, 1993Date of Patent: August 16, 1994Assignee: Ciba-Geigy CorporationInventor: Martin Missbach
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Patent number: 5229405Abstract: Compounds of the formula I ##STR1## in which R.sub.1 is lower alk-2-en-1-yl, lower alk-3-en-2-yl, lower alk-2-yn-1-yl or lower alkyl substituted in the 2,3-position by radicals which can be eliminated to give a double bond, R.sub.2 is hydrogen and R.sub.3 is methyl which is unsubstituted or substituted by radicals which can be eliminated together with hydrogen R.sub.2 to give a double bond or R.sub.2 and R.sub.3 are both hydrogen or lower alkyl or are together methylene and R.sub.4 is a group of the formula Ia, Ib or Ic ##STR2## in which R.sub.5 is hydrogen, lower alkyl, lower alk-2-en-1-yl or lower alk-2-yn-1-yl and R.sub.6 is a group of the formula Id or Ie ##STR3## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.5 are as defined, and their pharmaceutically acceptable salts can be used in a novel manner for the treatment of diseases of the rheumatoid type.Type: GrantFiled: April 10, 1992Date of Patent: July 20, 1993Assignee: Ciba-Geigy CorporationInventors: Ulrich Feige, Irmgard Wiesenberg, Leo Widler, Pier G. Ferrini, Martin Missbach
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Patent number: 5177091Abstract: Compounds of formula I ##STR1## wherein X and Y are each independently of the other thio or sulfynyl, R.sub.1 is lower alk-2-en-1-yl, lower alk-3-en-2-yl, lower alk-2--yn-1-yl, or lower alkyl that is substituted in the 2,3-position by radicals that can be eliminated to form a double bond, R.sub.2 is hydrogen and R.sub.3 is unsubstituted methyl or methyl substituted by a radical that can be eliminated together with hydrogen Rhd 2 to form a double bond, or R.sub.2 and R.sub.3 are each hydrogen or lower alkyl or together are methylene, R.sub.4 is free or protected hydroxy, or hydrogen, and R.sub.5 is hydrogen, lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, or lower alkyl that is substituted in the 2,3-position by radicals that can be eliminated to form a double bond, and their pharmaceutically acceptable salts may be used in a novel manner for the treatment of disorders of the rheumatoid type.Type: GrantFiled: November 20, 1991Date of Patent: January 5, 1993Assignee: Ciba-Geigy CorporationInventors: Ulrich Feige, Irmgard Wiesenberg, Leo Widler, Pier G. Ferrini, Martin Missbach