Patents by Inventor Martin Nazzaro
Martin Nazzaro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11819454Abstract: Assemblies for and methods of intraocular injection. An injector assembly includes a housing defining an internal chamber and having a slot on an external surface thereof; a cannula needle having a lumen and a cutout on an outer surface; a flexible arm having a proximal end affixed to the outer surface of the cannula needle and a distal end having a hook such that the hook is disposed within the cutout; a pushrod slidably disposed within the lumen; and a latch slidably disposed in the slot of the housing, the latch coupled to the pushrod such that translation of the latch causes translation of the pushrod to thereby eject an implant disposed within the lumen between the hook and pushrod.Type: GrantFiled: October 8, 2021Date of Patent: November 21, 2023Assignee: Inflammasome Therapeutics, Inc.Inventor: Martin Nazzaro
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Publication number: 20220226544Abstract: Provided herein are devices and methods for treating inflammation and pain of articular joints (e.g., the knee). An implantable device includes an elongate body extending from a proximal end to a distal end, a flange disposed at the proximal end, a bore extending from an opening at the proximal end into the elongate body, one or more fixation members disposed on an outer surface of the elongate body, and a payload (e.g., a drug-polymer core) having a therapeutic agent disposed within the bore. The payload has a substantially constant surface area on an exposed portion throughout elution of the therapeutic agent after the implantable device is implanted in a body. The therapeutic agent is configured to elute using zero-order kinetics, constantly and continuously at an amount that is above a predetermined lower threshold and does not exceed a predetermined upper threshold unlike a pulse-dose injection.Type: ApplicationFiled: January 14, 2022Publication date: July 21, 2022Inventors: Robert N. Hotchkiss, Paul Ashton, Martin Nazzaro
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Publication number: 20220168141Abstract: Provided herein are assemblies for and methods of intraocular injection. An injector assembly includes a housing defining an internal chamber and having a slot on an external surface thereof; a cannula needle having a lumen and a cutout on an outer surface; a flexible arm having a proximal end affixed to the outer surface of the cannula needle and a distal end having a hook such that the hook is disposed within the cutout; a pushrod slidably disposed within the lumen; and a latch slidably disposed in the slot of the housing, the latch coupled to the pushrod such that translation of the latch causes translation of the pushrod to thereby eject an implant disposed within the lumen between the hook and pushrod.Type: ApplicationFiled: October 8, 2021Publication date: June 2, 2022Inventor: Martin Nazzaro
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Patent number: 10363163Abstract: The devices and methods described herein relate to injector devices for delivering payloads to a tissue.Type: GrantFiled: September 10, 2015Date of Patent: July 30, 2019Assignee: EYEPOINT PHARMACEUTICALS, INC.Inventors: Martin Nazzaro, Josh York, Ron Leblanc
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Publication number: 20160074213Abstract: The devices and methods described herein relate to injector devices for delivering payloads to a tissue.Type: ApplicationFiled: September 10, 2015Publication date: March 17, 2016Inventors: Martin Nazzaro, Josh York, Ron Leblanc
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Publication number: 20140309610Abstract: This application provides a device for delivering a beneficial substance to a patient. The device comprises a shell enclosing a plurality of carrier particles. The carrier particles are porous, and a beneficial substance, such as a drug, is disposed in the pores. The drug can diffuse out of the pores, into the interior of the device, and then through at least one permeable portion of the shell. This application also provides methods of making and using these devices.Type: ApplicationFiled: March 12, 2014Publication date: October 16, 2014Applicant: pSivida Corp.Inventors: Leigh T. Canham, Hong Guo, Martin Nazzaro, Christian Barnett
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Patent number: 8790293Abstract: Disclosed herein is an injector device for delivering an implant, the device including a retracting element, a cannula needle, and a plunger. The device may comprise an latch that, when actuated by a user, causes the retracting element to move the cannula needle away from the delivery site, allowing the plunger to eject the implant into the site. The device may be configured for intraocular drug delivery.Type: GrantFiled: February 8, 2013Date of Patent: July 29, 2014Assignee: pSivida US, Inc.Inventors: Martin Nazzaro, Josh York, Ron LeBlanc
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Publication number: 20130267931Abstract: Disclosed herein is an injector device for delivering an implant, the device including a retracting element, a cannula needle, and a plunger. The device may comprise an latch that, when actuated by a user, causes the retracting element to move the cannula needle away from the delivery site, allowing the plunger to eject the implant into the site. The device may be configured for intraocular drug delivery.Type: ApplicationFiled: February 8, 2013Publication date: October 10, 2013Applicant: PSIVIDA US, INC.Inventors: Martin Nazzaro, Josh York, Ron LeBlanc
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Publication number: 20120238994Abstract: The invention provides a drug delivery device for latanoprost or latanoprost acid. The device has a core of latanoprost or latanoprost acid which is surrounded by an internal and external sheath. The external sheath has a first cap that is permeable to latanoprost or latanoprost acid. The first cap may comprise polyvinyl alcohol (PVA), and the PVA may be heat cured. In certain aspects, there are one or more additional caps on the ends of the sheaths formed from one or more polymers. In certain aspects, one or more portions of the drug delivery device is substantially impermeable to latanoprost or latanoprost acid. In certain aspects, the latanoprost or latanoprost acid elutes through the first cap into a biological environment. The invention further provides methods for manufacturing the drug delivery device.Type: ApplicationFiled: December 21, 2011Publication date: September 20, 2012Inventors: Martin Nazzaro, Josh York, Paul Ashton
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Publication number: 20120238993Abstract: The invention provides a drug delivery device for one or more drugs. The device has a drug core which is surrounded by an internal and external sheath. The external sheath has a first cap that is permeable to at least one drug in the core. The first cap may comprise polyvinyl alcohol (PVA), and the PVA may be heat cured. In certain aspects, there are one or more additional caps on the ends of the sheaths formed from one or more polymers. In certain aspects, one or more portions of the drug delivery device are substantially impermeable to one or more drugs in the drug core. In certain aspects, the drug elutes through the first cap into a biological environment. The invention further provides methods for manufacturing the drug delivery device.Type: ApplicationFiled: December 21, 2011Publication date: September 20, 2012Inventors: Martin Nazzaro, Josh York, Paul Ashton
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Patent number: 8192408Abstract: The invention provides a trocar assembly for delivering a payload into tissue, such as an eye, comprising a primary housing, a cannula, a payload, an actuator and a trocar.Type: GrantFiled: February 10, 2010Date of Patent: June 5, 2012Assignee: pSivida US, Inc.Inventors: Martin Nazzaro, Hong Guo, Ron LeBlanc, Josh York
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Patent number: 7998108Abstract: Disclosed herein is an injector device including an inserter element, a head element, an implant and a set of detachable protector elements for secured device handling. The device comprises a stop that controls the penetration depth of the device during injection. The device may comprise a removable catch that prevents the implant from exiting the device due to the advancement of its inserter element. The device may comprise a disengageable block that prevents the implant from exiting the device from its head element. The device may be configured for intraocular drug delivery.Type: GrantFiled: September 12, 2007Date of Patent: August 16, 2011Assignee: pSivida US, Inc.Inventors: Martin Nazzaro, Hong Guo, Ron LeBlanc, Josh York
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Publication number: 20100234817Abstract: The invention provides a trocar assembly for delivering a payload into tissue, such as an eye, comprising a primary housing, a cannula, a payload, an actuator and a trocar.Type: ApplicationFiled: February 10, 2010Publication date: September 16, 2010Applicant: pSivida Inc.Inventors: Martin Nazzaro, Hong Guo, Ron LeBlanc, Josh York
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Publication number: 20080071246Abstract: Disclosed herein is an injector device including an inserter element, a head element, an implant and a set of detachable protector elements for secured device handling. The device comprises a stop that controls the penetration depth of the device during injection. The device may comprise a removable catch that prevents the implant from exiting the device due to the advancement of its inserter element. The device may comprise a disengageable block that prevents the implant from exiting the device from its head element. The device may be configured for intraocular drug delivery.Type: ApplicationFiled: September 12, 2007Publication date: March 20, 2008Applicant: pSivida Inc.Inventors: Martin Nazzaro, Hong Guo, Ron LeBlanc, Josh York
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Patent number: D851755Type: GrantFiled: October 22, 2015Date of Patent: June 18, 2019Assignee: EyePoint Pharmaceuticals US, Inc.Inventors: Martin Nazzaro, Josh York, Ron Leblanc