Patents by Inventor Martin Neitzel

Martin Neitzel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-substituted benzene sulfonamides
    Publication number: 20120270902
    Abstract: The invention provides N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. Compounds of particular interest are defined by Formula (I), wherein R1, R2, R3, R4, and R3?, are as described in the specification. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders, including Alzheimer's disease using compounds of Formula (I).
    Type: Application
    Filed: February 13, 2012
    Publication date: October 25, 2012
    Applicant: ELAN PHARMACEUTICALS, INC.
    Inventors: Martin Neitzel, Jennifer Marugg
  • N-substituted benzene sulfonamides
    Patent number: 8193389
    Abstract: The invention provides N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. Compounds of particular interest are defined by Formula (I), wherein R1, R2, R3, R4, and R3?, are as described in the specification. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders, including Alzheimer's disease using compounds of Formula (I).
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: June 5, 2012
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Martin Neitzel, Jennifer Marugg
  • N-Substituted Benzene Sulfonamides
    Publication number: 20110212920
    Abstract: Disclosed are N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. In Formula (I), R1, R2, R3, R4, R3?, R10 and R11 are as described herein. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).
    Type: Application
    Filed: May 9, 2011
    Publication date: September 1, 2011
    Inventors: Martin Neitzel, Michael S. Dappen, Jennifer Marugg
  • N-substituted benzene sulfonamides
    Patent number: 7939657
    Abstract: Disclosed are N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. In Formula (I), R1, R2, R3, R4, R3?, R10 and R11 are as described herein. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).
    Type: Grant
    Filed: April 23, 2007
    Date of Patent: May 10, 2011
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Martin Neitzel, Michael S. Dappen, Jennifer Marugg
  • Piperidinyl Cyclic Amido Antiviral Agents
    Publication number: 20100272680
    Abstract: Provided are compounds of Formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).
    Type: Application
    Filed: February 9, 2010
    Publication date: October 28, 2010
    Inventors: Subramanian Baskaran, Jack Maung, Martin Neitzel, Rai Roopa, Christopher Roberts, Vincent Tai
  • Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists
    Patent number: 7635775
    Abstract: Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists.
    Type: Grant
    Filed: May 5, 2006
    Date of Patent: December 22, 2009
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Francine S. Grant, Sarah Bartulis, Louis Brogley, Michael S. Dappen, Ramesh Kasar, Mohammed A. Khan, Martin Neitzel, Michael A. Pleiss, Eugene D. Thorsett, John Tucker, Michael Ye, Jon E. Hawkinson
  • N-substituted heterocyclic sulfonamides
    Patent number: 7569562
    Abstract: The invention provides N-substituted heterocyclic-sulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. Compounds of particular interest are defined by Formula (I), wherein R1, R2, Z and n are as described in the specification. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).
    Type: Grant
    Filed: January 18, 2006
    Date of Patent: August 4, 2009
    Assignee: Elan Pharmaceuticals, Inc.
    Inventor: Martin Neitzel
  • Substituted pyrazole derivatives and related compounds as bradykinin Breceptor antagonists
    Patent number: 7432379
    Abstract: Disclosed are compounds that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: October 7, 2008
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Jay S. Tung, Albert W. Garofalo, Michael A. Pleiss, Jing Wu, David W. G. Wone, Ashley C. Guinn, Darren B. Dressen, R. Jeffrey Neitz, Jennifer Marugg, Martin Neitzel
  • 4-bromo-5-(2-chloro-benzoylamino)-1H-pyrazole-3-carboxylic acid amide derivatives and related compounds as bradykinin Breceptor antagonists for the treatment of inflammatory diseases
    Patent number: 7417152
    Abstract: Disclosed are compounds of formula I and II that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: August 26, 2008
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Jay S. Tung, Albert W. Garofalo, Michael A. Pleiss, Jing Wu, David W. G. Wone, Ashley C. Guinn, Darren B. Dressen, R. Jeffrey Neitz, Jennifer Marugg, Martin Neitzel
  • Bridged N-Cyclic Sulfonamido Inhibitors of Gamma Secretase
    Publication number: 20080090817
    Abstract: The invention provides N-cyclic sulfonamido compounds and salts of Formula I: wherein A is as described in the specification and R1 and R2 combine to form a [3.3.1] or a [3.2.1] ring system, where the nitrogen is attached to the two bridgehead carbons, and the [3.3.1] or [3.2.1] ring systems are optionally fused with an heteroaryl or heterocycloalkyl ring. Compounds of Formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's Disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I, methods of treating cognitive disorders, such as Alzheimer's disease, and the intermediates useful in preparing the compounds of Formula I.
    Type: Application
    Filed: December 5, 2007
    Publication date: April 17, 2008
    Inventors: Simeon Bowers, Albert Garofalo, Roy Hom, Andrei Konradi, Matthew Mattson, Martin Neitzel, Christopher Semko, Anh Truong, Jing Wu, Ying-zi Xu
  • Fused, Tricyclic Sulfonamide Inhibitors of Gamma Secretase
    Publication number: 20080021056
    Abstract: The invention provides compounds of formula I: or pharmaceutically salts thereof where R1, R2, and the A, B, and C-rings are as defined herein. Compounds of formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's disease. The invention also encompasses pharmaceutical compositions comprising compounds or salts of formula I, methods of preparing the desired compounds, and methods of treating cognitive disorders, such as Alzheimer's disease, using the compounds or salts of formula I.
    Type: Application
    Filed: June 1, 2007
    Publication date: January 24, 2008
    Inventors: Andrei Konradi, Gary Probst, Danielle Aubele, Albert Garofalo, Roy Hom, Martin Neitzel, Christopher Semko, Anh Truong
  • N-Substituted Benzene Sulfonamides
    Publication number: 20070191341
    Abstract: Disclosed are N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. In Formula (I), R1, R2, R3, R4, R3?, R10 and R11 are as described herein. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).
    Type: Application
    Filed: April 23, 2007
    Publication date: August 16, 2007
    Inventors: Martin Neitzel, Michael Dappen, Jennifer Marugg
  • 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carboxylic acid (1-aminocarbonyl)eth-1-yl) amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases
    Publication number: 20070161633
    Abstract: Disclosed are compounds of formulae (I) and (II) that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action. Wherein Z is selected from O, S and NH; Q of formula (III) and the other substituents are as defined in claim 1.
    Type: Application
    Filed: April 30, 2004
    Publication date: July 12, 2007
    Applicant: Elan Pharmaceuticals, Inc.
    Inventors: Jay Tung, Albert Garofalo, Michael Pleiss, Jing Wu, David Wone, Ashley Guinn, Darren Dressen, Jennifer Marugg, Martin Neitzel
  • 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carboxylic acid (phenyl) amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases
    Publication number: 20070123531
    Abstract: Disclosed are compounds that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.
    Type: Application
    Filed: April 30, 2004
    Publication date: May 31, 2007
    Inventors: Albert Garofalo, Jay Tung, Michael Pleiss, Jing Wu, David Wone, Ashley Guinn, Darren Dressen, Jennifer Marugg, Martin Neitzel
  • N-substituted benzene sulfonamides
    Patent number: 7208488
    Abstract: Disclosed are N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. In Formula (I), R1, R2, R3, R4, R3?, R10 and R11 are as described herein. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: April 24, 2007
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Martin Neitzel, Michael S. Dappen, Jennifer Marugg
  • Bridged N-Cyclic Sulfonamido Inhibitors of Gamma Secretase
    Publication number: 20070049612
    Abstract: The invention provides N-cyclic sulfonamido compounds and salts of Formula I: wherein A is as described in the specification and R1 and R2 combine to form a [3.3.1] or a [3.2.1] ring system, where the nitrogen is attached to the two bridgehead carbons, and the [3.3.1] or [3.2.1] ring systems are optionally fused with an heteroaryl or heterocycloalkyl ring. Compounds of Formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's Disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I, methods of treating cognitive disorders, such as Alzheimer's disease, and the intermediates useful in preparing the compounds of Formula I.
    Type: Application
    Filed: August 18, 2006
    Publication date: March 1, 2007
    Inventors: Simeon Bowers, Albert Garofalo, Roy Hom, Andrei Konradi, Matthew Mattson, Martin Neitzel, Christopher Semko, Anh Truong, Jing Wu, Ying-zi Xu
  • Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists
    Patent number: 7183281
    Abstract: Disclosed are sulfonylquinoxalone derivatives of the general formula: These compounds are useful as bradykinin antagonists.
    Type: Grant
    Filed: May 2, 2003
    Date of Patent: February 27, 2007
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Francine S. Grant, Sarah Bartulis, Louis Brogley, Michael S. Dappen, Ramesh Kasar, Mohammed A. Khan, Martin Neitzel, Michael A. Pleiss, Eugene D. Thorsett, John Tucker, Michael Ye, Jon E. Hawkinson
  • Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists
    Publication number: 20060293332
    Abstract: Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists.
    Type: Application
    Filed: May 5, 2006
    Publication date: December 28, 2006
    Inventors: Francine Grant, Sarah Bartulis, Louis Brogley, Michael Dappen, Ramesh Kasar, Mohammed Khan, Martin Neitzel, Michael Pleiss, Eugene Thorsett, John Tucker, Michael Ye, Jon Hawkinson
  • 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carvoxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases
    Publication number: 20060281733
    Abstract: Disclosed are compounds of formula I and II that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.
    Type: Application
    Filed: April 30, 2004
    Publication date: December 14, 2006
    Inventors: Jay Tung, Albert Garofalo, Michael Pleiss, Jing Wu, David Wone, Ashley Guinn, Darren Dressen, R. Jeffrey Neitz, Jennifer Marugg, Martin Neitzel
  • N-substituted heterocyclic sulfonamides
    Publication number: 20060270657
    Abstract: The invention provides N-substituted heterocyclic-sulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. Compounds of particular interest are defined by Formula (I), wherein R1, R2, Z and n are as described in the specification. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).
    Type: Application
    Filed: January 18, 2006
    Publication date: November 30, 2006
    Inventor: Martin Neitzel