Patents by Inventor Martin Ostendorf

Martin Ostendorf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combined synthesis route for desogestrel and etonogestrel
    Patent number: 9464108
    Abstract: The present invention relates to a synthesis route and to steroid derivatives of general formula VI and VII useful in the synthesis of desogestrel and etonogestrel.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: October 11, 2016
    Assignee: Merck Sharp & Dohme B.V.
    Inventor: Martin Ostendorf
  • COMBINED SYNTHESIS ROUTE FOR DESOGESTREL AND ETONOGESTREL
    Publication number: 20150031875
    Abstract: The present invention relates to a synthesis route and to steroid derivatives of general formula VI and VII useful in the synthesis of desogestrel and etonogestrel.
    Type: Application
    Filed: March 13, 2013
    Publication date: January 29, 2015
    Inventor: Martin Ostendorf
  • Process for the preparation of estrone and/or estradiol-derivatives
    Patent number: 8273908
    Abstract: Process for the preparation of a compound of general formula (II) wherein R1 and R2 independently are hydrogen or a hydroxy- or hydrocarbyl group; or wherein R1 and R2 together are a double bonded oxygen; R3 is hydrogen; R?4 is a nitrobenzophenone group; and R5 and R6 independently are hydrogen or a hydroxy- or hydrocarbyl group; from a compound of general formula (I) wherein, R1, R2 R3, R5 and R6 are as defined above and R4 is hydrogen; wherein the compound of formula (I) is reacted under alkaline conditions with 2-chloro-5-nitrobenzophenone in the presence of an alkanolic solvent and the compound of formula (II) is directly crystallized from this alkanolic solvent. Complex of an alkanol and a compound of general formula (II) obtainable from the above process and processes wherein the above process or complex are used.
    Type: Grant
    Filed: August 22, 2005
    Date of Patent: September 25, 2012
    Assignee: MSD Oss B.V.
    Inventors: Lambertus Gerardus Maria Willems, Henricus Johannes Franciscus Maas, Martin Ostendorf
  • PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING TUBERCULOSIS
    Publication number: 20120058977
    Abstract: A pharmaceutical composition for the treatment of a disease caused by a bacterium that belongs to the group of nocardioform actinomycetes, said composition comprising an effective amount of a compound selected from compound I, (+)-compound II, (?)-compound II, compound III, or mixtures thereof.
    Type: Application
    Filed: February 23, 2010
    Publication date: March 8, 2012
    Applicant: Rijksuniversiteit Groningen
    Inventors: Robert Van Der Geize, Lubbert Dijkhuizen, Martin Ostendorf, Peter Van Der Meijden
  • Process For The Preparation of 7 alpha-Methylsteroids
    Publication number: 20100204497
    Abstract: The invention relates to a process for the preparation of 7?-methyl hydroxy steroids of the formula I wherein R1 is hydrogen, methyl or C?CH; R2 is (CH2)nOH, wherein n is 0, 1 or 2; by a copper mediated 1,6-conjugate addition of a Grignard reagent CH3MgX, X being a halogen, to the 4,6-unsaturated 3-ketosteroid of formula II, wherein R1 and R2 are as previously defined, comprising protecting the hydroxy group of the steroid of formula II with a trialkylsilyl group, followed by treating the hydroxy protected steroid with the Grignard reagent. The process of the invention is useful for the production of pharmacologically interesting steroids.
    Type: Application
    Filed: April 22, 2010
    Publication date: August 12, 2010
    Inventors: Patrick Arnoldus Maria Van Buggenum, Johannes Stoelwinder, Martin Ostendorf
  • Process for the Preparation of Estrone and/or Estradiol-Derivates
    Publication number: 20070299268
    Abstract: Process for the preparation of a compound of general formula (II) wherein R1 and R2 independently are hydrogen or a hydroxy- or hydrocarbyl group; or wherein R1 and R2 together are a double bonded oxygen; R3 is hydrogen; R?4 is a nitrobenzophenone none group; and R5 and R6 independently are hydrogen or a hydroxy- or hydrocarbyl group; from a compound of general formula (I) wherein, R1, R2 R3, R5 and R6 are as defined above and R4 is hydrogen; wherein the compound of formula (I) is reacted under alkaline conditions with 2-chloro-5-nitrobenzophenone in the presence of an alkanolic solvent and the compound of formula (II) is directly crystallized from this alkanolic solvent. Complex of an alkanol and a compound of general formula (II) obtainable from the above process and processes wherein the above process or complex are used.
    Type: Application
    Filed: August 22, 2005
    Publication date: December 27, 2007
    Applicant: N.V. Organon
    Inventors: Lambertus Gerardus Willems, Henricus Johannes Maas, Martin Ostendorf
  • Process for the preparation of 7alpha-methylsteroids
    Publication number: 20050090476
    Abstract: The invention relates to a process for the preparation of 7?-methyl hydroxy steroids of the formula I wherein R1 is hydrogen, methyl or C?CH; R2 is (CH2)nOH, wherein n is 0, 1 or 2; by a copper mediated 1,6-conjugate addition of a Grignard reagent CH3MgX, X being a halogen, to the 4,6-unsaturated 3-ketosteroid of formula II, wherein R1 and R2 are as previously defined, comprising protecting the hydroxy group of the steroid of formula II with a trialkylsilyl group, followed by treating the hydroxy protected steroid with the Grignard reagent. The process of the invention is useful for the production of pharmacologically interesting steroids.
    Type: Application
    Filed: January 14, 2003
    Publication date: April 28, 2005
    Inventors: Patrick, Arnoldus, Maria Van Buggenum, Johannes Stoelwinder, Martin Ostendorf