Abstract: In one aspect, the present disclosure provides compounds which inhibit bromodomain testis (BRDT). In some embodiments, the compounds inhibit bromodomain-2 of BRDT. In another aspect, the present disclosure provides a method of inhibiting BRDT in a male subject, the method comprising administering to the male subject a therapeutically effective amount of a compound of the disclosure. In some embodiments, the method provides a contraceptive effect in the male subject.

Abstract: Computer systems, apparatuses, processors, and non-transitory computer-readable storage devices configured for executing a method for generating proactive advisor recommendation using artificial intelligence. The method has the steps of: partitioning a plurality of clients using a clustering model based on data of the plurality of clients for clustering the plurality of clients into a plurality of client clusters; classifying the clients of at least a first client cluster of the plurality of client clusters into a plurality of client classifications by using one or more random-forest classifiers; and generating financial recommendations for the clients of at least a first client classification of the plurality of client classifications.

Abstract: A method of selecting ions comprises selecting ions corresponding to a target ion of interest by separating analyte ions according to their ion mobility, isolating first ions of the analyte ions, separating the first ions according to their ion mobility, and isolating second ions of the first ions. Preferably, the separation is accomplished by using a cyclic or closed-loop separator.

Abstract: Tubular bait fish retrieval apparatuses comprise a generally cylindrically-shaped or prism-shaped body comprising an opening on a first end thereof configured to allow passage of a bait fish therethrough, and a generally closed second end having at least one aperture configured to fill the body with water when disposed within the water and for draining the water from the body when removed from the water. Methods of using the same are further provided.

Abstract: An electric machine is described together with a stator. The electric machine comprises a stator, said stator comprising a cylindrical stator core having an end face; slots provided on the end face, each slot running through the stator core; a plurality of conductor bars disposed within the slots; and an end face assembly electrically connecting at least two of the conductor bars; a rotor having a plurality of magnetic pole pairs; and a controller electrically connected to said stator for regulating an excitation current supplied to or from the conductor bars, wherein the controller regulates an amplitude of the excitation current independently of a frequency of the excitation current. This arrangement simplifies stator construction and allows for optimisation of the electric machine.

Abstract: A composite material which is elastic, which exhibits a resistive load under deformation which increases with the rate of deformation, which is unfoamed or foamed, comminuted or uncomminuted and which comprises i) a first polymer-based elastic material and ii) a second polymer-based material, different from i), which exhibits dilatancy in the absence of i) wherein ii) is entrapped in a solid matrix of i), the composite material being unfoamed or, when foamed, preparable by incorporating ii) with i) prior to foaming.

Abstract: An electric machine is described together with a stator. The electric machine comprises a stator, said stator comprising a cylindrical stator core having an end face; slots provided on the end face, each slot running through the stator core; a plurality of conductor bars disposed within the slots; and an end face assembly electrically connecting at least two of the conductor bars; a rotor having a plurality of magnetic pole pairs; and a controller electrically connected to said stator for regulating an excitation current supplied to or from the conductor bars, wherein the controller regulates an amplitude of the excitation current independently of a frequency of the excitation current. This arrangement simplifies stator construction and allows for optimisation of the electric machine.

Abstract: A composite material which is elastic, which exhibits a resistive load under deformation which increases with the rate of deformation, which is unfoamed or foamed, comminuted or uncomminuted and which comprises i) a first polymer-based elastic material and ii) a second polymer-based material, different from i), which exhibits dilatancy in the absence of i) wherein ii) is entrapped in a solid matrix of i), the composite material being unfoamed or, when foamed, preparable by incorporating ii) with i) prior to foaming.

Abstract: A composite material which is elastic, which exhibits a resistive load under deformation which increases with the rate of deformation, which is unfoamed or foamed, comminuted or uncomminuted and which comprises i) a first polymer-based elastic material and ii) a second polymer-based material, different from i), which exhibits dilatancy in the absence of i) wherein ii) is entrapped in a solid matrix of i), the composite material being unfoamed or, when foamed, preparable by incorporating ii) with i) prior to foaming.

Abstract: A composite material which is elastic, which exhibits a resistive load under deformation which increases with the rate of deformation, which is unfoamed or foamed, comminuted or uncomminuted and which comprises i) a first polymer-based elastic material and ii) a second polymer-based material, different from i), which exhibits dilatancy in the absence of i) wherein ii) is entrapped in a solid matrix of i), the composite material being unfoamed or, when foamed, preparable by incorporating ii) with i) prior to foaming.

Abstract: A self-supporting energy absorbing composite includes: i) a solid foamed synthetic polymer matrix; ii) a polymer-based dilatant, different from i) distributed through the matrix and incorporated therein during manufacture of i); and iii) a fluid distributed through the matrix. In another embodiment, a self-supporting energy absorbing composite includes: iv) a solid, closed cell foam matrix; v) a polymer-based dilatant, different from i), distributed through the matrix; and vi) a fluid distributed through the matrix. In both embodiments, the combination of matrix, dilatant and fluid is such that the composite is resiliently compressible.

Abstract: A self-supporting energy absorbing composite includes: i) a solid foamed synthetic polymer matrix; ii) a polymer-based dilatant, different from i) distributed through the matrix and incorporated therein during manufacture of i); and iii) a fluid distributed through the matrix. In another embodiment, a self-supporting energy absorbing composite includes: iv) a solid, closed cell foam matrix; v) a polymer-based dilatant, different from i), distributed through the matrix; and vi) a fluid distributed through the matrix. In both embodiments, the combination of matrix, dilatant and fluid is such that the composite is resiliently compressible.

Abstract: A self-supporting energy absorbing composite includes: i) a solid foamed synthetic polymer matrix; ii) a polymer-based dilatant, different from i) distributed through the matrix and incorporated therein during manufacture of i); and iii) a fluid distributed through the matrix. In another embodiment, a self-supporting energy absorbing composite includes: iv) a solid, closed cell foam matrix; v) a polymer-based dilatant, different from i), distributed through the matrix; and vi) a fluid distributed through the matrix. In both embodiments, the combination of matrix, dilatant and fluid is such that the composite is resiliently compressible.

Abstract: An emulsion explosive composition is especially suited to being pneumatically loaded into a blasthole. The emulsion explosive composition includes a base emulsion phase which has a continuous fuel phase and a discontinuous oxidiser phase, wherein the viscosity of the base emulsion phase is less than 2000 cP (Brookfleld viscosity #4 spindle at 50 rpm) at 25°C.

Abstract: An emulsion explosive composition comprising a base emulsion phase which comprises a continuous fuel phase and a discontinuous oxidiser phase, wherein the viscosity of the base emulsion phase is less than 2000 cP (Brookfield viscosity #4 spindle at 50 rpm) at 25° C.

Abstract: An apparatus and process for the production of any emulsion explosives composition and loading it into a blast hole (7) which utilize a loading conduit (4) having a shear inducing means (5) and a liquid lubrication source (b) adapted to provide a layer of liquid lubricant between the conduit (4) and emulsion explosives composition being pumped through the loading conduit (4). The conduit also comprises a mixing means (8) located at or near the outlet of the conduit (4), the mixing means (8) incorporates at least some of the liquid layer into the emulsion explosives composition.