Abstract: The present invention provides methods for the treatment of non-alcoholic steatohepatitis (NASH) including advanced fibrotic and/or cirrhotic stages of NASH. The methods include administration of a compound comprising a double stranded RNAi (dsRNAi) oligonucleotide, or a pharmaceutically acceptable salt thereof, to the patient. The dsRNAi oligonucleotide optionally contains an antisense strand and a sense strand, wherein the antisense strand and the sense strand form a duplex region, and wherein the antisense strand comprises a region of complementarity to a KHK mRNA target sequence.

Abstract: dsRNAi oligonucleotides can be used in methods for the treatment of NASH, preferably the advanced fibrotic and/or cirrhotic stages thereof, using dosage regimens comprising a loading phase followed by a maintenance phase.

Abstract: The present invention concerns a shoe upper, including (a) a first sheet, (b) a second sheet, (c) a connecting region in which the first sheet is connected to the second sheet, and (d) a first coating. The first coating is applied onto a first region of the first sheet, a second region of the second sheet, and a third region of the connecting region. The first region, the second region, and the third region are connected.

Abstract: An inspection apparatus includes an inspection signal source configured to irradiate a wafer with an inspection ray having a frequency in a range of 0.1 terahertz (THz) to 10 THz, a curved rail, a probe mount configured to move along the curved rail, and first and second probes coupled to the probe mount, wherein the first probe is configured to detect the inspection ray transmitted through the wafer, and the curved rail has a curved surface convex toward the first and second probes.

Abstract: The present disclosure provides a light detection and ranging (LIDAR) system, which comprises: a distance measuring unit configured to emit a plurality of first pulses towards an object located in a field of view (FOV), wherein the object is associated with one or more markers; and a detector configured to receive at least one second pulse from the one or more markers of the object, wherein each of the at least one second pulse indicates object information identifying the object.

Abstract: Some embodiments include an integrated structure having vertically-stacked conductive levels alternating with dielectric levels. A layer over the conductive levels includes silicon, nitrogen, and one or more of carbon, oxygen, boron and phosphorus. In some embodiments the vertically-stacked conductive levels are wordline levels within a NAND memory array. Some embodiments include an integrated structure having vertically-stacked conductive levels alternating with dielectric levels. Vertically-stacked NAND memory cells are along the conductive levels within a memory array region. A staircase region is proximate the memory array region. The staircase region has electrical contacts in one-to-one correspondence with the conductive levels. A layer is over the memory array region and over the staircase region. The layer includes silicon, nitrogen, and one or more of carbon, oxygen, boron and phosphorus.

Abstract: Exemplary support assemblies may include a top puck and a backing plate coupled with the top puck. The support assemblies may include a cooling plate coupled with the backing plate. The support assemblies may include a heater coupled between the cooling plate and the backing plate. The support assemblies may also include a back plate coupled with the backing plate about an exterior of the backing plate. The back plate may at least partially define a volume, and the heater and the cooling plate may be housed within the volume.

Abstract: Embodiments herein are directed to a pedal pad assembly. The pedal pad assembly includes an outer housing that has a cavity, an inner housing that has an outer surface and is slidably received within the cavity of the outer housing, a pedal pad coupled to the inner housing and is configured to translate the inner housing along a movement axis in response to a load applied to the pedal pad and a sensor assembly that includes a plurality of target members coupled to the outer surface of the inner housing and a sensor configured to sense a position of at least one target member. During a translation of the inner housing along the movement axis, at least one target member of the plurality of target members moves with the inner housing from a first position to a second position indicative of the movement of the inner housing within the cavity.

Abstract: Embodiments herein are directed to a pedal pad assembly. The pedal pad assembly includes an outer housing that has a cavity, an inner housing that has an outer surface and is slidably received within the cavity of the outer housing, a pedal pad coupled to the inner housing and is configured to translate the inner housing along a movement axis in response to a load applied to the pedal pad and a sensor assembly that includes a plurality of target members coupled to the outer surface of the inner housing and a sensor configured to sense a position of at least one target member. During a translation of the inner housing along the movement axis, at least one target member of the plurality of target members moves with the inner housing from a first position to a second position indicative of the movement of the inner housing within the cavity.

Abstract: A flight control apparatus for fixed-wing aircraft includes a first port wing and first starboard wing, a first port swash plate coupled between a first port rotor and first port electric motor, the first port electric motor coupled to the first port wing, and a first starboard swash plate coupled between a first starboard rotor and first starboard electric motor, the first starboard electric motor coupled to the first starboard wing.

Abstract: A flight control apparatus for fixed-wing aircraft includes a first port wing and first starboard wing, a first port swash plate coupled between a first port rotor and first port electric motor, the first port electric motor coupled to the first port wing, and a first starboard swash plate coupled between a first starboard rotor and first starboard electric motor, the first starboard electric motor coupled to the first starboard wing.

Abstract: A flight control apparatus for fixed-wing aircraft includes a first port wing and first starboard wing, a first port swash plate coupled between a first port rotor and first port electric motor, the first port electric motor coupled to the first port wing, and a first starboard swash plate coupled between a first starboard rotor and first starboard electric motor, the first starboard electric motor coupled to the first starboard wing.

Abstract: A flight control apparatus for fixed-wing aircraft includes a first port wing and first starboard wing, a first port swash plate coupled between a first port rotor and first port electric motor, the first port electric motor coupled to the first port wing, and a first starboard swash plate coupled between a first starboard rotor and first starboard electric motor, the first starboard electric motor coupled to the first starboard wing.

Abstract: A flight control apparatus for fixed-wing aircraft includes a first port wing and first starboard wing, a first port swash plate coupled between a first port rotor and first port electric motor, the first port electric motor coupled to the first port wing, and a first starboard swash plate coupled between a first starboard rotor and first starboard electric motor, the first starboard electric motor coupled to the first starboard wing.

Abstract: A flight control apparatus for fixed-wing aircraft includes a first port wing and first starboard wing, a first port swash plate coupled between a first port rotor and first port electric motor, the first port electric motor coupled to the first port wing, and a first starboard swash plate coupled between a first starboard rotor and first starboard electric motor, the first starboard electric motor coupled to the first starboard wing.

Abstract: A flight control apparatus for fixed-wing aircraft includes a first port wing and first starboard wing, a first port swash plate coupled between a first port rotor and first port electric motor, the first port electric motor coupled to the first port wing, and a first starboard swash plate coupled between a first starboard rotor and first starboard electric motor, the first starboard electric motor coupled to the first starboard wing.

Abstract: A flight control apparatus for fixed-wing aircraft includes a first port wing and first starboard wing, a first port swash plate coupled between a first port rotor and first port electric motor, the first port electric motor coupled to the first port wing, and a first starboard swash plate coupled between a first starboard rotor and first starboard electric motor, the first starboard electric motor coupled to the first starboard wing.

Abstract: A handheld gripping device provides a user with a point of stability in maneuvering in various indoor situations. In one aspect, the device includes a handle portion, a base from which the handle portion extends, one or more suction elements positioned relative to the base, and a cam driven mechanism coupled with each suction element and with the base. The cam driven mechanism selectively draws the respective suction element towards and away from the base.

Abstract: A pneumatic tire-type compacter is mounted to be towed behind a road maintainer to pack the road immediately after it is graded. A single hydraulic cylinder raises the packer unit for maneuvering the grader; also, the hydraulic cylinder provides means for transferring weight from the maintainer onto the packer. Links between the maintainer and compacter provide proper operation. A small moldboard is attached to the compacter in front of the compacter to handle the dirt rolled from the maintainer.