Abstract: Compounds of Formula (I): wherein R1, R3, R11, R12, X, Y1, Y2, Y3, Y4 and are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring anti-apoptotic inhibitors.

Abstract: The present disclosure relates to non-surgical methods for delivery of an agent to the respiratory system of a subject, methods of treatment using delivery of agents to the respiratory system, devices for delivery of agents to the respiratory system, and use of such devices to deliver agents to the respiratory system. In certain embodiments, the present disclosure provides a provide a non-surgical method of delivering an agent to the respiratory system of a subject. The method comprises in vivo perturbation of the airway surface in one or more parts of the respiratory system in the subject and exposing the perturbed surface of the airway to the agent, thereby delivering the agent to the respiratory system of the subject.

Abstract: A load-restraining barrier net for use in a motor vehicle capable of securing cargo within the trunk area of a vehicle in accordance with established safety requirements. The barrier net includes a body primarily made up of diamond/square or hexagon shaped netting, frame strap webbings around the perimeter of the net, and at least two horizontal and at least two vertical central strap webbings across the center of the net. The net is securely affixed on one side through a first set of attachments including oval rings bolted to the vehicle. These attachments prevent the cargo from slipping below the net to an unsecured position. Further, corner oval rings act as the joint attachment for the vertical and horizontal frame strap webbings, allowing the barrier net to withstand angular momentum from inertial forces. A second, releasable, set of attachments including hooks and/or D-ring connections that attach to D-rings and/or fasteners pre-installed in the vehicle.