Abstract: The disclosure relates to antibodies and antigen-binding fragments thereof that bind to Stem Cell Factor (SCF). The antibodies and antigen-binding fragments thereof specifically bind to SCF248. The disclosure further relates to methods for making the antibodies, and to methods of use of the antibodies including methods of treatment for inflammatory and/or fibrotic diseases and disorders.

Abstract: The invention relates to a process for forming a pre-defined recess in a cured or cast explosive composition comprising the steps of: i) providing a female mould, ii) providing a male former, and locating said male former proximate to the female mould to create a gap between said male former and female mould, iii) forming an admixture of a curable/castable explosive composition, charging the gap with the admixture of explosive composition, causing the cure or cast of said curable/castable explosive composition, removing the male former to furnish a cured or cast explosive composition with a pre-defined recess.

Abstract: The invention relates to a process for forming a pre-defined recess in a cured or cast explosive composition comprising the steps of: i) providing a female mould, ii) providing a male former, and locating said male former proximate to the female mould to create a gap between said male former and female mould, iii) forming an admixture of a curable/castable explosive composition, charging the gap with the admixture of explosive composition, causing the cure or cast of said curable/castable explosive composition, removing the male former to furnish a cured or cast explosive composition with a pre-defined recess.

Abstract: Described is a shaft support system for a gas turbine engine comprising: a rotatable fan shaft; first and second support structures extending in parallel from the shaft to a load bearing structure to provide radial location of the shaft within an engine casing, wherein the first support and second support structures include first and second respective mechanical fusible joints; wherein the first fusible joint is a two-stage fuse which partially fails within a first predetermined load range, the second fusible joint fails within a second predetermined load range which is different to the first load range, and the first fusible joint fully fails only when the second fusible joint has failed.

Abstract: In managing the backlog of undelivered publications for durable subscriptions, a maximum quantity of publications stored in connection with a durable subscription to publications of a particular topic can be established on behalf of a particular subscribing end user. A new publication published for the particular topic subscribed to by the end user can be received and it can be determined if storing the new publication in connection with the durable subscription causes a quantity of publications stored in connection with the durable subscription to exceed the maximum quantity. The new publication can be stored in connection with the durable subscription; however, the oldest publication stored in connection with the durable subscription can be removed when it is determined that storing the new publication in connection with the durable subscription causes a quantity of publications stored in connection with the durable subscription to exceed the maximum quantity.

Abstract: The present invention features a composition comprising a first agent and a second agent for treating disorder associated with aberrant activity in the HPA axis like an addiction to a substance (e.g., cocaine, amphetamines, methamphetamine, methylphenidate, heroin, coedine, hydrocodone, nicotine, alcohol, prescription medication (e.g., Percodan®, Percoset®), marijuana, tobacco, methadone, food), addiction to an activity (e.g., gambling, sex, eating), substance use disorders, mood disorders, anxiety disorders, bipolar disorder, sleep disorders, insomnia, posttraumatic stress syndrome, borderline personality disorder, disruptive behavior disorders, ADHD, major depressive disorder, burnout, chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, eating disorders (e.g., Prader Willi Syndrome), obesity, depression, menopause, prementsrual syndrome (PMS), obsessive compulsive disorder (OCD), social anxiety, generalized anxiety disorder, dysthymia, or schizophrenia.

Abstract: The present invention features a composition comprising a first agent and a second agent for treating disorder associated with aberrant activity in the HPA axis like an addiction to a substance (e.g., cocaine, amphetamines, methamphetamine, methylphenidate, heroin, codeine, hydrocodone, nicotine, alcohol, prescription medication (e.g., Percodan®, Percoset®), marijuana, tobacco, methadone, food), addiction to an activity (e.g., gambling, sex, eating), substance use disorders, mood disorders, anxiety disorders, bipolar disorder, sleep disorders, insomnia, posttraumatic stress syndrome, borderline personality disorder, disruptive behavior disorders, ADHD, major depressive disorder, burnout, chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, eating disorders (e.g., Prader Willi Syndrome), obesity, depression, menopause, premenstrual syndrome (PMS), obsessive compulsive disorder (OCD), social anxiety, generalized anxiety disorder, dysthymia, or schizophrenia.

Abstract: A bypass system for a transmission is disclosed. A transmission casing defines a first aperture and a second aperture. A valve assembly includes a housing defining a first port and a second port. The housing defines an inlet in fluid communication with the first port for guiding a fluid into the transmission casing and an outlet in fluid communication with the second port for guiding the fluid out of the transmission casing. The valve assembly further includes an actuation device disposed in the housing. The housing is mounted to the transmission casing such that the first port and the first aperture cooperate with each other for routing the fluid into the transmission casing directly from the valve assembly, and the second port and the second aperture cooperate with each other for routing the fluid out of the transmission casing directly into the valve assembly.

Abstract: A bypass system for a transmission is disclosed. A transmission casing defines a first aperture and a second aperture. A valve assembly includes a housing defining a first port and a second port. The housing defines an inlet in fluid communication with the first port for guiding a fluid into the transmission casing and an outlet in fluid communication with the second port for guiding the fluid out of the transmission casing. The valve assembly further includes an actuation device disposed in the housing. The housing is mounted to the transmission casing such that the first port and the first aperture cooperate with each other for routing the fluid into the transmission casing directly from the valve assembly, and the second port and the second aperture cooperate with each other for routing the fluid out of the transmission casing directly into the valve assembly.

Abstract: An attachable visor may include a block, wherein the block has a doughnut hole shaped cutout having an inner ring. The block may be made from a closed cell foam. The block may be of a circular shape with a diameter of approximately fifteen to sixteen inches in length. The block thickness may be reduced down to an approximately 0.25 inches. The doughnut hole shaped cutout may be approximately five and one-half inches in diameter. The attachable visor may be placed over a hat or helmet in order to provide additional protection from the weather elements.

Abstract: Harvesting articular chondrocyte cells from a non-critical location of a patient and growing additional cells for transplantation into a damaged or diseased disc of the patient.

Abstract: Seat belt web retractors and associated systems and methods are described herein. Web retractors assemblies configured in accordance with various embodiments of the present technology can include, for example, a frame having a first sidewall and a second sidewall opposite the first sidewall, and a spring-loaded shaft extending between the first and second sidewalls. The web retractor can further include a locking mechanism positioned proximate to the first sidewall of the frame and operably coupled to the shaft. The locking mechanism can include a vehicle inertia sensor and/or a web inertia sensor. A cover can enclose the locking mechanism such that the cover and the first sidewall form a liquid-sealed enclosure around the locking mechanism.

Abstract: A device (2) which can be formed into safety link comprising a flexible, longitudinally elongate member having engagable first and second portions (4, 6); the first end portion (4) including a recess (8) which is open-ended in the longitudinal direction and defined, at least in part, by a pair of opposed interior side walls (10, 12); the second end portion (6) having sidewalls (18, 20) that are complementary to the sidewalls (10, 12) of the recess (8) so that the second end portion (6) is a push-fit in the recess (8); at least one pair of the complementary side-walls being non-planar so as to retain the first end portion (4) in the recess (8) against a longitudinally applied force until it is sufficient to move the side-walls (10, 12) of the recess (8) apart to release the second end portion (6) from the recess.

Abstract: A door stay device for automatically locking a door in an open position includes a first component adapted to be attached to a stationary support, the first component including a plate having a curved cam edge with a radius matched to a swinging movement of the door between closed and open positions. The plate has a slot open at the cam edge at a location corresponding to the open position of the door. A second component is adapted to be secured at a lower or upper edge of a door, the second component having a locking member arranged to move into the slot when the locking member is aligned with the slot and the door is in the open position.

Abstract: In managing the backlog of undelivered publications for durable subscriptions, a maximum quantity of publications stored in connection with a durable subscription to publications of a particular topic can be established on behalf of a particular subscribing end user. A new publication published for the particular topic subscribed to by the end user can be received and it can be determined if storing the new publication in connection with the durable subscription causes a quantity of publications stored in connection with the durable subscription to exceed the maximum quantity. The new publication can be stored in connection with the durable subscription; however, the oldest publication stored in connection with the durable subscription can be removed when it is determined that storing the new publication in connection with the durable subscription causes a quantity of publications stored in connection with the durable subscription to exceed the maximum quantity.

Abstract: In one embodiment, an iceboard includes a plank having a first end and a second end and a first side and a second side. One or more supports are coupled to the first side of the plank and, one or more blades are coupled to the one or more supports, the blades operable to glide across an icy surface. The iceboard further includes a piece of frictional material coupled to the second side of the plank and operable to provide traction relative to the plank. The iceboard further includes a brake coupled to the first side of the plank adjacent a first end of the plank. In particular embodiments, the brake is operable to abrasively scrape the icy surface when applied to the icy surface.

Abstract: A musical instrument pick holder that provides convenient temporary storage of one or more picks. The pick holder provides a housing that is the same or substantially the same shape as the pick. The pick holder stores one or more picks therein and provides for quick and easy access to the picks. The pick holder has an internal biasing member that releasably retains the picks therein. The pick holder further provides one or more exterior surfaces that are suitable for placement of advertising or marketing indicia or graphical elements. The pick holder further comprises a key ring or other clasping element for releasable coupling with another items such as the garment of a musician.

Abstract: In one embodiment, an iceboard includes a plank having a first end and a second end and a first side and a second side. One or more supports are coupled to the first side of the plank and, one or more blades are coupled to the one or more supports, the blades operable to glide across an icy surface. The iceboard further includes a piece of frictional material coupled to the second side of the plank and operable to provide traction relative to the plank. The iceboard further includes a brake coupled to the first side of the plank adjacent a first end of the plank. In particular embodiments, the brake is operable to abrasively scrape the icy surface when applied to the icy surface.

Abstract: Modified human factor VIII cDNA wherein mutations are inserted either in the wild-type factor VIII cDNA or in a factor VIII cDNA in which the B-domain is partially or completely deleted and may be replaced by a DNA linker segment and