Patents by Inventor Martin Piest
Martin Piest has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250057938Abstract: The present invention relates to liquid vaccine composition comprising a live virus and a natural deep-eutectic solvent (NADES) as the carrier. The carrier additionally comprises an additive selected from methionine and (hydroxy) ectoine. The additive is able to reduce the loss of virus titre over time, upon storage in a NADES-based liquid vaccine composition having up to 50% w/w of water. Such compositions are less viscous which is favourable for the manufacture of the carrier, and the formulation and use of the liquid vaccine.Type: ApplicationFiled: December 22, 2022Publication date: February 20, 2025Applicant: INTERVET INC.Inventors: Edwin KETS, Martin PIEST, Paul VERMEIJ
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Publication number: 20250057934Abstract: The present invention relates to the field of vaccinology, more specifically of veterinary vaccinology. In particular, the invention relates to an adjuvant composition comprising an emulsion of water, tocopherol or a pharmaceutically acceptable ester thereof, and a polyethoxyethylene cetostearyl ether as an emulsifier. Said adjuvant composition can be used for formulating a vaccine, particularly an emulsion vaccine, comprising a bacterial, parasitic, or viral antigen. The resulting vaccine composition can be used in a method of protecting a human or animal target against infection and/or disease caused by a pathogen, particularly caused by a bacterium, parasite or virus. The invention further relates to methods for the manufacture of such adjuvant compositions and for the manufacture of such vaccine composition.Type: ApplicationFiled: December 23, 2022Publication date: February 20, 2025Applicant: INTERVET INC.Inventors: Martin PIEST, Marc THEELEN, Franciscus Gerardus Antonios MANDERS, Maarten Hendrik WITVLIET
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Patent number: 12214027Abstract: The present invention relates to a liquid composition of live Mollicutes bacteria and a stabiliser, whereby the stabiliser is a natural deep-eutectic solvent (NADES). In this liquid composition the live Mollicutes are stabilised without need for freezing or freeze-drying. This allows various advantageous uses in diagnostics and medicine, specifically as a liquid vaccine for use against infection or disease caused by Mollicutes bacteria, for human- or non-human animals.Type: GrantFiled: March 27, 2020Date of Patent: February 4, 2025Assignee: INTERVET INC.Inventors: Martin Piest, Edwin Kets, Paul Vermeij, Marian Anna Catharina Jozefina Heijnen, Nöel Dautzenberg
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Publication number: 20240165020Abstract: Described herein are oral pharmaceutical compositions suitable for chewing, sucking, or buccal dissolution comprising soft gel capsules and liquid fills, methods for making the same, and methods for treating subjects in need thereof with such capsules. In particular, oral pharmaceutical compositions comprising chewable, suckable, or dissolvable soft gel capsules with various flowable fill compositions are described.Type: ApplicationFiled: November 30, 2023Publication date: May 23, 2024Inventors: YinYan Zhao, Yunhua Hu, Mervin Williams, JR., Tatyana Dyakonov, Saujanya Gosangari, Chue Yang, Henricus Marinus, Gerardus, Maria Van Duijnhoven, Martin Piest, Aqeel A. Fatmi
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Patent number: 11872307Abstract: Described herein are oral pharmaceutical compositions suitable for chewing, sucking, or buccal dissolution comprising soft gel capsules and liquid fills, methods for making the same, and methods for treating subjects in need thereof with such capsules. In particular, oral pharmaceutical compositions comprising chewable, suckable, or dissolvable soft gel capsules with various flowable fill compositions are described.Type: GrantFiled: March 25, 2022Date of Patent: January 16, 2024Assignee: PATHEON SOFTGELS INC.Inventors: YinYan Zhao, Yunhua Hu, Mervin Williams, Jr., Tatyana Dyakonov, Saujanya Gosangari, Chue Yang, Henricus Marinus Gerardus Maria Van Duijnhoven, Martin Piest, Aqeel A. Fatmi
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Publication number: 20220323567Abstract: The present invention relates to the field of veterinary vaccinology, namely to combination vaccines for swine. In particular the invention relates to a combination vaccine for protection against a pathogenic infection with porcine circo vims type 2 (PCV2) and Mycoplasma hyopneumoniae (Mhyo) comprising non-replicating immunogen of PCV2 and non-replicating immunogen of Mhyo. The vaccine is characterized in that it is an oil-in-water emulsion comprising squalane, vitamin E-acetate and silica. In another embodiment, the invention relates to a combination vaccine for protection against a pathogenic infection with PCV2 and Mhyo by intradermal administration.Type: ApplicationFiled: September 11, 2020Publication date: October 13, 2022Inventors: Theodorus Jansen, Melanie SNO, Martin PIEST
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Publication number: 20220211616Abstract: Described herein are oral pharmaceutical compositions suitable for chewing, sucking, or buccal dissolution comprising soft gel capsules and liquid fills, methods for making the same, and methods for treating subjects in need thereof with such capsules. In particular, oral pharmaceutical compositions comprising chewable, suckable, or dissolvable soft gel capsules with various flowable fill compositions are described.Type: ApplicationFiled: March 25, 2022Publication date: July 7, 2022Inventors: YinYan Zhao, Yunhua Hu, Mervin Williams, JR., Tatyana Dyakonov, Saujanya Gosangari, Chue Yang, Henricus Marinus, Gerardus, Maria Van Duijnhoven, Martin Piest, Aqeel A. Fatmi
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Publication number: 20220175902Abstract: The present invention relates to a liquid composition of live Mollicutes bacteria and a stabiliser, whereby the stabiliser is a natural deep-eutectic solvent (NADES). In this liquid composition the live Mollicutes are stabilised without need for freezing or freeze-drying. This allows various advantageous uses in diagnostics and medicine, specifically as a liquid vaccine for use against infection or disease caused by Mollicutes bacteria, for human- or non-human animals.Type: ApplicationFiled: March 27, 2020Publication date: June 9, 2022Applicant: Intervet Inc.Inventors: Martin Piest, Edwin Kets, Paul Vermeij, Marian Anna Catharina Jozefina Huijnen, Noel Dautzenberg
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Patent number: 11344617Abstract: The present invention describes a liquid vaccine composition of a live enveloped virus and a pharmaceutically acceptable carrier, whereby the carrier is a natural deep-eutectic solvent (NADES), and the vaccine has a water activity of less than about 0.8. The NADES provides a stabilisation of the sensitive virus for prolonged time and at ambient temperature. In general, the liquid vaccine compositions according to the invention, in different compositions for the various enveloped viruses, show remarkable capabilities of stabilisation. This overcomes the need for lyophilisation, a great economic benefit. Also the liquid nature of the vaccines facilitates administration to human or animal targets.Type: GrantFiled: December 21, 2018Date of Patent: May 31, 2022Assignee: Intervet Inc.Inventors: Paul Vermeij, Edwin Kets, Chris Dirks, Martin Piest
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Publication number: 20210353573Abstract: The present invention is directed to a suspension-based liquid fill formulation for a capsule comprising ibuprofen lysine and a medium chain triglyceride (MCT). More particularly, the present invention is directed to a soft-gel capsule containing suspension-based fill formulation ibuprofen lysine, medium chain triglyceride (MCT) and lecithin, method of manufacture and use thereof.Type: ApplicationFiled: October 3, 2019Publication date: November 18, 2021Inventors: Michael Hilary BURKE, Helena Maria de Albuquerque Ferreira TELES, Martin PIEST
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Publication number: 20200368346Abstract: The present invention describes a liquid vaccine composition of a live enveloped virus and a pharmaceutically acceptable carrier, whereby the carrier is a natural deep-eutectic solvent (NADES), and the vaccine has a water activity of less than about 0.8. The NADES provides a stabilisation of the sensitive virus for prolonged time and at ambient temperature. In general, the liquid vaccine compositions according to the invention, in different compositions for the various enveloped viruses, show remarkable capabilities of stabilisation. This overcomes the need for lyophilisation, a great economic benefit. Also the liquid nature of the vaccines facilitates administration to human or animal targets.Type: ApplicationFiled: December 21, 2018Publication date: November 26, 2020Applicant: Intervet Inc.Inventors: Paul Vermeij, Edwin Kets, Chris Dirks, Martin Piest
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Publication number: 20200121595Abstract: Described herein are oral pharmaceutical compositions suitable for chewing, sucking, or buccal dissolution comprising soft gel capsules and liquid fills, methods for making the same, and methods for treating subjects in need thereof with such capsules. In particular, oral pharmaceutical compositions comprising chewable, suckable, or dissolvable soft gel capsules with various flowable fill compositions are described.Type: ApplicationFiled: December 20, 2019Publication date: April 23, 2020Inventors: YinYan Zhao, Yunhua Hu, Mervin Williams, JR., Tatyana Dyakonov, Saujanya Gosangari, Chue Yang, Henricus Marinus, Gerardus, Maria Van Duijnhoven, Martin Piest, Aqeel A. Fatmi
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Patent number: 10555901Abstract: Described herein are oral pharmaceutical compositions suitable for chewing, sucking, or buccal dissolution comprising soft gel capsules and liquid fills, methods for making the same, and methods for treating subjects in need thereof with such capsules. In particular, oral pharmaceutical compositions comprising chewable, suckable, or dissolvable soft gel capsules with various flowable fill compositions are described.Type: GrantFiled: October 27, 2017Date of Patent: February 11, 2020Assignee: PATHEON SOFTGELS INCInventors: YinYan Zhao, Yunhua Hu, Mervin Williams, Jr., Tatyana Dyakonov, Saujanya Gosangari, Chue Yang, Henricus Marinus Gerardus Maria Van Duijnhoven, Martin Piest, Aqeel A Fatmi
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Patent number: 10357467Abstract: Described herein are soft capsules and enteric soft capsules comprising cationic Type A gelatin and acid insoluble enteric polymers. In particular, the compositions and methods for manufacturing all-natural enteric soft capsules comprising Type A gelatin and matrix fills are described. In one embodiment, the enteric soft capsules comprise active ingredients such as non-steroidal anti-inflammatory drugs (NSAIDs). In another embodiment, the enteric soft capsule comprises matrix fills of omega-3 fatty acids.Type: GrantFiled: May 30, 2018Date of Patent: July 23, 2019Assignee: Patheon Softgels, Inc.Inventors: Yunhua Hu, Martin Piest, Qi Fang, Henricus M. G. M. van Duijnhoven
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Publication number: 20180271817Abstract: Described herein are soft capsules and enteric soft capsules comprising cationic Type A gelatin and acid insoluble enteric polymers. In particular, the compositions and methods for manufacturing all-natural enteric soft capsules comprising Type A gelatin and matrix fills are described. In one embodiment, the enteric soft capsules comprise active ingredients such as non-steroidal anti-inflammatory drugs (NSAIDs). In another embodiment, the enteric soft capsule comprises matrix fills of omega-3 fatty acids.Type: ApplicationFiled: May 30, 2018Publication date: September 27, 2018Inventors: Yunhua HU, Martin PIEST, Qi FANG, Henricus M.G.M. van Duijnhoven
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Patent number: 9987240Abstract: Described herein are soft capsules and enteric soft capsules comprising cationic Type A gelatin and acid insoluble enteric polymers. In particular, the compositions and methods for manufacturing all-natural enteric soft capsules comprising Type A gelatin and matrix fills are described. In one embodiment, the enteric soft capsules comprise active ingredients such as non-steroidal anti-inflammatory drugs (NSAIDs). In another embodiment, the enteric soft capsule comprises matrix fills of omega-3 fatty acids.Type: GrantFiled: September 28, 2017Date of Patent: June 5, 2018Assignee: Patheon Softgels, Inc.Inventors: Yunhua Hu, Martin Piest, Qi Fang, Henricus M. G. M. van Duijnhoven
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Patent number: 9901554Abstract: A special class of drug-depot forming triblock copolymers which are very suitable for the loading, containment and releasing of sensitive drugs such as proteins from biodegradable, injectable drug depots. How to visualize these depots for various imaging related purposes is described. A composition comprising a tri-block copolymer according to formula 1 B-A-B (1), wherein A stands for a linear poly-(ethylene glycol) block and wherein B stands for wherein B stands for a poly(lactide-co-?-caprolactone) block, wherein the hydroxyl end-groups of the tri-block copolymer are at least partially acylated with an optionally substituted acyl having 2 to 12 C-atoms, C-atoms of the substituents included; an active ingredient, preferably a pharmaceutically active ingredient and a solvent, wherein the block ratio of the tri-block copolymer, which ratio is defined as the ratio between the sum of the average molecular weight of the B-blocks and the sum of the average molecular weight of the A-block ranges from 1.4 to 3.5.Type: GrantFiled: April 2, 2012Date of Patent: February 27, 2018Assignee: INGELL TECHNOLOGIES HOLDING B.V.Inventors: Peter Bruin, Audrey Petit, Mike De Leeuw, Martin Piest, Ronald Meijboom
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Publication number: 20180049979Abstract: Described herein are oral pharmaceutical compositions suitable for chewing, sucking, or buccal dissolution comprising soft gel capsules and liquid fills, methods for making the same, and methods for treating subjects in need thereof with such capsules. In particular, oral pharmaceutical compositions comprising chewable, suckable, or dissolvable soft gel capsules with various flowable fill compositions are described.Type: ApplicationFiled: October 27, 2017Publication date: February 22, 2018Inventors: YinYan Zhao, Yunhua Hu, Mervin Williams, Tatyana Dyakonov, Saujanya Gosangari, Chue Yang, Henricus Marinus, Gerardus, Maria Van Duijnhoven, Martin Piest, Aqeel A. Fatmi
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Publication number: 20180015059Abstract: Described herein are soft capsules and enteric soft capsules comprising cationic Type A gelatin and acid insoluble enteric polymers. In particular, the compositions and methods for manufacturing all-natural enteric soft capsules comprising Type A gelatin and matrix fills are described. In one embodiment, the enteric soft capsules comprise active ingredients such as non-steroidal anti-inflammatory drugs (NSAIDs). In another embodiment, the enteric soft capsule comprises matrix fills of omega-3 fatty acids.Type: ApplicationFiled: September 28, 2017Publication date: January 18, 2018Inventors: Yunhua HU, Martin PIEST, Qi FANG, Henricus M.G.M. van Duijnhoven
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Patent number: 9867779Abstract: Described herein are oral pharmaceutical compositions suitable for chewing, sucking, or buccal dissolution comprising soft gel capsules and liquid fills, methods for making the same, and methods for treating subjects in need thereof with such capsules. In particular, oral pharmaceutical compositions comprising chewable, suckable, or dissolvable soft gel capsules with various flowable fill compositions are described.Type: GrantFiled: March 25, 2016Date of Patent: January 16, 2018Assignee: Patheon Softgels Inc.Inventors: Yinyan Zhao, Yunhua Hu, Mervin Williams, Tatyana Dyakonov, Saujanya Gosangari, Chue Yang, Henricus Marinus Gerardus Maria Van Duijnhoven, Martin Piest, Aqeel A Fatmi