Abstract: A method for mapping cancer includes inputting data elements from medical images, biopsy, and biopsy pathology labels into a machine learning model estimating the likelihood of clinically significant cancer in a patient and outputting, via the machine learning model, an estimate of the clinically significant cancer likelihood at each voxel of a three-dimensional image

Abstract: The present invention provides methods of determining cancer margins indicating the location and breadth of treatment necessary for the elimination of cancerous tissue during focal laser therapy. The present invention also provides systems and devices for focal laser therapy, and methods for using the same. The present invention does not rely on MRI thermometry, improving accuracy of treatment while also reducing treatment time and cost.

Abstract: A process for the manufacture of quaternized diaminoanthraquinones by reacting alpha-nitro-anthraquinone with an amine of the formula ##STR1## to give 1-aminoanthraquinone (B), halogenating, preferably brominating the compound (B) to give 1-amino-4-halogeno- or 1-amino-2,4-dihalogeno-anthraquinone (C), condensing the compound (C) with a diamine of the formula ##STR2## or with an amine of the formula HNR.sub.3 R.sub.7 to give 1,4-diaminoanthraquinone (D) and subsequently quaternizing compound (D) to give the corresponding quaternized anthraquinone compound (E) which process comprises carrying out the condensation of compound (C) with the amine to form compound (D) and subsequent quaternization steps in one single operation without isolation of the intermediate (D).

Abstract: A process for the manufacture of 1,4-diamino anthraquinone or quaternized -1,4-diamino-anthraquinone; and by reacting .alpha.-nitro-anthraquinone with an amine of the formula ##STR1## to give 1-aminoanthraquinone (B), halogenating, preferably brominating, the compound (B) to give 1-amino-4-halogeno- or 1-amino-2,4-dihalogeno-anthraquinone (C), condensing the compound (C) with a diamine of the formula ##STR2## or with an amine of the formula HN--R.sub.3 R.sub.7 to give 1,4-diamino-anthraquinone (D) and optionally subsequently quaternizing the compound (D) to give a quaternized anthraquinone compound which process comprises carrying out the reaction from A to E or A to D in one single operation without isolation of the intermediates.