Patents by Inventor Martin Putala

Martin Putala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of sartan derivatives and intermediates useful in such process
    Patent number: 7868180
    Abstract: The invention provides a process for the preparation of a sartan derivative of formula (I) (formula as filed in paper form) (I) wherein the substituents have the meaning indicated in the description, or a pharmaceutically acceptable salt thereof, comprising reacting 2-cyanophenylboronic acid or a derivative thereof with a p-halobenzyl-1H-imidazole derivative of formula (VI), (formula as filed in paper form) (VI) wherein (part of formula as filed in paper form), X, Y, R1 and R2 are as defined above, and Z is I, Br or Cl, in the presence of a transition metal catalyst and an inorganic or organic base. The invention also provides new intermediates of formula (V), (formula as filed in paper form) (V) wherein M is an alkali metal or an NR4R5R6R7 group; and of formula (II) (formula as filed in paper form) (II).
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: January 11, 2011
    Assignee: KRKA, d.d. Novo mesto
    Inventors: Miroslav Veverka, Martin Putala, Heinrich Brath, Silvo Zuppancic
  • Process For the Preparation of Sartan Derivatives and Intermediates Useful in Such Process
    Publication number: 20080312451
    Abstract: The invention provides a process for the preparation of a sartan derivative of formula (I) (formula as filed in paper form) (I) wherein the substituents have the meaning indicated in the description, or a pharmaceutically acceptable salt thereof, comprising reacting 2-cyanophenylboronic acid or a derivative thereof with a p-halobenzyl-1H-imidazole derivative of formula (VI), (formula as filed in paper form) (VI) wherein (part of formula as filed in paper form), X, Y, R1 and R2 are as defined above, and Z is I, Br or Cl, in the presence of a transition metal catalyst and an inorganic or organic base.
    Type: Application
    Filed: September 20, 2006
    Publication date: December 18, 2008
    Applicant: KRKA, d.d. Novo mesto
    Inventors: Miroslav Veverka, Martin Putala, Heinrich Brath, Silvo Zuppancic