Abstract: A method and apparatus are provided for aligning optical elements or microbeads 8, wherein each microbead has an elongated body with a code embedded therein along a longitudinal axis thereof to be read by a code reading device. The microbeads 8 are aligned with a positioning device (or cell) 500 having a plate or platform 200, 1252 with grooves 205, 1258 so the longitudinal axis of the microbeads is positioned in a fixed orientation relative to the code reading device. The microbeads 8 are typically cylindrically shaped glass beads having a diffraction grating-based code embedded in the bead 8 disposed along an axis, which requires a predetermined alignment between the incident code readout laser beam and the code readout detector in two of three rotational axes. The geometry of the grooves 205 are designed to allow for easy loading and unloading of beads from a cell, and the grooves 205 may be straight or curved.

Abstract: A method for manufacturing a diffusion grating-based optical identification element is provided. The optical identification element includes a known optical substrate, having an optical diffraction grating disposed in the volume of the substrate. A large number of substrates or microbeads having unique identification codes can be manufactured by winding a substrate, such as a fiber, around a polygonal shaped cage/basket to form a fiber ribbon having flat sections. A grating writing station writes one or more gratings into each flat section to form a unique code to this section. Each flat section of fibers of the fiber ribbon is written with the same gratings to provide the same identification code, or alternatively each flat section may be have a different grating(s) written therein so that each section has a different identification code. The fiber ribbon is then removed from the cage and diced to form a groups of optical identification elements, each group having unique optical identification codes.

Abstract: An optical identification element for identifying an item comprises a binder material and one or more materials embedded in the binder material. The one or more materials provide an encoded composite X-ray diffraction pattern when illuminated by an X-ray beam. The encoded composite X-ray diffraction pattern is indicative of the item. The one or more materials are preferably powdered crystal materials. The optical identification element may be shaped as a microbead or a macrobead. Alternatively, the binder material may be in the form of a thread or fiber. The labeled item may be selected from the group, comprising: large or small objects, products, solids, powders, liquids, gases, plants, pharmaceuticals, currency, ID cards, minerals, cells and/or animals. The item may be a chemical or a DNA sequence.

Abstract: The present invention provides a method for making a multicore large diameter optical waveguide having a cross-section of at least about 0.3 millimeters, two or more inner cores, a cladding surrounding the two or more inner cores, and one or more side holes for reducing the bulk modulus of compressibility and maintaining the anti-buckling strength of the large diameter optical waveguide. The method features the steps of: assembling a preform for drawing a multicore large diameter optical waveguide having a cross-section of at least about 0.3 millimeters, by providing an outer tube having a cross-section of at least about 0.3 millimeters and arranging two or more preform elements in relation to the outer tube; heating the preform; and drawing the large diameter optical waveguide from the heated preform. In one embodiment, the method also includes the step of arranging at least one inner tube inside the outer tube.

Abstract: The present invention provides a new and unique method for increasing the photosensitivity of a large diameter optical waveguide having a cross-section of at least about 0.3 millimeters. The method features loading the large diameter optical waveguide with a photosensitizing gas at a pressure at least about 4000 pounds per square inch (PSI) at a temperature of at least about 250° Celsius. The photosensitizing gas may be hydrogen, Deuterium or other suitable gas. The method also includes the step of using a particular large diameter optical waveguide having a core more than 1000 microns from the surface thereof. The method may be used as part of a process for writing a Bragg grating in an inner core or a cladding of the large diameter optical waveguide.

Abstract: A large diameter optical waveguide, grating, and laser includes a waveguide 10 having at least one core 12 surrounded by a cladding 14, the core propagating light in substantially a few transverse spatial modes; and having an outer waveguide dimension d2 of said waveguide being greater than about 0.3 mm. At least one Bragg grating 16 may be impressed in the waveguide 10. The waveguide 10 may be axially compressed which causes the length L of the waveguide 10 to decrease without buckling. The waveguide 10 may be used for any application where a waveguide needs to be compression tuned, e.g., compression-tuned fiber gratings and lasers or other applications. Also, the waveguide 10 exhibits lower mode coupling from the core 12 to the cladding 14 and allows for higher optical power to be used when writing gratings 16 without damaging the waveguide 10. The shape of the waveguide 10 may have other geometries (e.g.

Abstract: A method and apparatus are provided for aligning optical elements or microbeads, wherein each microbead has an elongated body with a code embedded therein along a longitudinal axis thereof to be read by a code reading device. The microbeads are aligned with a positioning device so the longitudinal axis of the microbeads is positioned in a fixed orientation relative to the code reading device. The microbeads are typically cylindrically shaped glass beads between 25 and 250 microns (?m) in diameter and between 100 and 500 ?m long, and have a holographic code embedded in the central region of the bead, which is used to identify it from the rest of the beads in a batch of beads with many different chemical probes. A cross reference is used to determine which probe is attached to which bead, thus allowing the researcher to correlate the chemical content on each bead with the measured fluorescence signal.

Abstract: The present invention provides a filament with an easily removable protective coating as well as a method and apparatus for applying the protective coating to the filament during a draw process that can be easily removed with a reasonably benign solvent such as water, or if necessary, acetone or ethanol. The protective coating is water-soluble and can be easily dissolved in-line with a spooling process. The coating material may include a water-soluble “wax-like” material called Aquabond 65, distributed by Aquabond Technologies, as well as other grades of Aquabond such Aquabond 55 and Aquabond 85, which behave essentially the same but are dissolved at different temperatures.

Abstract: A method and apparatus is provided for writing a code on an optical element, wherein the code is written on the optical element in the form of a holographic image of an n-dimensional code generated by an interference pattern between a reference beam and a signal beam reflected off a spatial light modulation device having the n-dimensional code configured thereon. The method includes steps of generating the interference pattern between the reference beam and the signal beam reflected off the spatial light modulation device having the n-dimensional code thereon; as well as writing the interference pattern on the optical element as a holographic image of the n-dimensional code.

Abstract: An assay stick 7 includes a transparent reaction vessel or tube 14 having one or more microbeads 8 disposed therein. The microbeads 8 have a plurality of unique identification digital codes based on a diffraction grating 12 disposed therein that are detected when illuminated by incident light 24. The incident light 24 may be directed transversely onto the side or onto an end of the tube 14 with a narrow band (single wavelength) or multiple wavelength source, in which case the code is represented by a spatial distribution of light or a wavelength spectrum, respectively. The assay stick 7 may be reused or disposed upon completion of the assay. Alternatively, the beads may be attached to a strip or planar surface. The encoded beads can also provide traceability, quality-control, and authenticity of each bead 8 to its source and/or to the chemistry on each bead 8. Also, the low sample volume of the assay stick allows for faster reactions and better sensitivity.

Abstract: An optical reader system 7 for diffraction grating-based encoded microbeads (or bead reader system), comprises a reader box 100, which accepts a bead cell (or cuvette) 102 that holds the microbeads 8, having an embedded code therein. The reader box 100 interfaces along lines 103 with a known computer system 104. The reader box 100 interfaces with a stage position controller 112 and the controller 112 interfaces along a line 115 with the computer system 104 and a manual control device (or joy stick) 116 along a line 117. The reader interrogates the microbeads to determine the embedded code and/or the fluorescence level on the beads. The reader provides information similar to a bead flow cytometer but in a planar format, i.e., a virtual cytometer.

Abstract: A method and apparatus are provided for aligning optical elements or microbeads 8, wherein each microbead has an elongated body with a code embedded therein along a longitudinal axis thereof to be read by a code reading device. The microbeads 8 are aligned with a positioning device (or cell) 500 having a plate or platform 200, 1252 with grooves 205, 1258 so the longitudinal axis of the microbeads is positioned in a fixed orientation relative to the code reading device. The microbeads 8 are typically cylindrically shaped glass beads having a diffraction grating-based code embedded in the bead 8 disposed along an axis, which requires a predetermined alignment between the incident code readout laser beam and the code readout detector in two of three rotational axes. The geometry of the grooves 205 are designed to allow for easy loading and unloading of beads from a cell, and the grooves 205 may be straight or curved.

Abstract: The present invention generally provides multicomponent articles of manufacture and methods of making them. In its broadest aspect, the invention provides a multicomponent article that includes a diffraction grating-based encoded element, wherein the encoded element includes an optical substrate having at least one surface, and an optical coding element; and a substance disposed on at least a portion of the surface of the substrate. The optical substrate may be made from a wide variety of materials. Importantly the multicomponent article may be a reagent particle wherein the substance includes a reagent. The reagent may be chosen from a wide range of biological macromolecules and oligomeric molecules, from any organic chemical or inorganic chemical compound including pharmaceutical agents and candidate pharmaceutical agents, modifications of any of them, and from any microbiological entity, a cell, and similar entities.

Abstract: A method and apparatus for drug product tracking (or other pharmaceutical, health care or cosmetics products, and/or the packages or containers they are supplied with) using diffraction grating-based encoded optical identification elements 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 has one or more colocated pitches ? which represent a unique identification digital code that is detected when illuminated by incident light 24. The incident light 24 may be directed transversely from the side of the substrate 10 (or from an end) with a narrow band (single wavelength) or multiple wavelength source, and the code is represented by a spatial distribution of light or a wavelength spectrum, respectively, or a combination thereof. The encoded element 8 may be used to label any desired item, such as drugs or medicines, or other pharmaceutical or health care products or cosmetics.

Abstract: An optical identification element 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 has a one or more of collocated pitches ? which represent a unique identification N bit digital code that is detected when illuminated by incident light 24. The incident light 24 may be directed transversely onto the side or onto an end of the substrate 10 with a narrow band (single wavelength) or multiple wavelength source, in which case the code is represented by a spatial distribution of light or a wavelength spectrum, respectively. The element 8 can provide a large number of unique codes, e.g., greater than 67 million codes, and can withstand harsh environments. The element 8 can be used in any application that requires sorting, tagging, tracking or identification, and can be made on a micron scale “microbeads” if desired, or larger “macro-elements” for larger applications. The code may be digital binary or may be other numerical bases.

Abstract: An optical identification element 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 has a one or more of collocated pitches A which represent a unique identification N bit digital code that is detected when illuminated by incident light 24. The incident light 24 may be directed transversely onto the side or onto an end of the substrate 10 with a narrow band (single wavelength) or multiple wavelength source, in which case the code is represented by a spatial distribution of light or a wavelength spectrum, respectively. The element 8 can provide a large number of unique codes, e.g., greater than 67 million codes, and can withstand harsh environments. The element 8 can be used in any application that requires sorting, tagging, tracking or identification, and can be made on a micron scale “microbeads” if desired, or larger “macro-elements” for larger applications. The code may be digital binary or may be other numerical bases.

Abstract: The present invention provides methods and compositions directed toward assays of a broad range of analytes using specific targeting chemicals that bind to the analytes. The assays are founded on the use of coded assay articles to which the targeting chemicals are attached. Additionally the codes are such that they are interrogated and determined in real time. The target is analyzed as to identity, presence and quantity in real time. The methods and compositions of the invention are highly suitable for use in high-complexity multiplexed assay systems. All the methods and compositions are based on assay article that includes an optical substrate to which the chemical is bound, and in which is disposed at least one diffraction grating. The grating provides an output optical signal when illuminated by an incident light signal which is indicative of the code in the substrate.

Abstract: An optical identification element (also known herein as a microbead) is provided made from pieces of an optical fiber or substrate that includes an inner core or region being surrounded by an outer cladding region, the optical fiber or substrate having an identification code imparted therein containing coded information. The identification code may be in the form of a Bragg grating inscribed or written in either the inner core or outer cladding. The optical identification element may be microscopic in size having a length in a range of 1-1,000 microns or smaller; or for larger applications may have a length of 1.0-1,000 millimeters or more. The outer diameter may be as small as less than 1,000 microns, as well as in a range of 1.0 to 1,000 millimeters for larger applications.

Abstract: An optical sensing device including a force-applying assembly for providing a force and a Fabry-Perot (FP) element including a large-diameter waveguide having a core and having a cavity in line with the core, the cavity having reflective surfaces and having an optical path length related to the distance between the reflective surfaces, the FP element being coupled to the force so that the optical path length changes according to the force, the FP element for providing an output optical signal containing information about a parameter that relates to the force. Sometimes the large-diameter waveguide is formed by collapsing a glass tube, having a bore and having an outer diameter of about one millimeter, onto a pair of optical fibers arranged in tandem in the bore and separated by a predetermined distance, and respective end faces of the optical fibers form the cavity and are coated with a wholly or partially reflective material.

Abstract: A fluid diffusion resistant tube-encased fiber grating pressure sensor includes an optical fiber 10 having a Bragg grating 12 impressed therein which is encased within a sensing element, such as a glass capillary shell 20. A fluid blocking coating 30 is disposed on the outside surface of the capillary shell to prevent the diffusion of fluids, such as water molecules from diffusing into the shell. The fluid diffusion resistant fiber optic sensor reduces errors caused by the diffusion of water into the shell when the sensor is exposed to harsh conditions.