Publication number: 20060100431
Abstract: Compounds of general formula (I) wherein Z=CR3R4, where R3 and R4 are independently chosen from C0-7-alkyl P1=CR5R6, P2=O, CR7R8 or NR9, Y=CR10R11—C(O) or CR10R11—C(S) or CR10R11—S(O) or CR10R11—SO2(X)0=.CR16R17 (W)n=0, S, C(O), S(O) or S(O)2— or NR18(V)m=C(O), C(S), S(O), S(O)2, S(O)2NH, OC(O), NHC(O), NHS(O), NHS(O)2, OC(O)NH, C(O)NH or CR19R20, C?N—C(O)—OR19 or C?N?C(O)—NHR19, U=a stable. 5- to 7 membered monocyclic or a stable 8- to 11-membered bicyclic ring which is either saturated or unsaturated, and which includes zero to four heteroatoms and their sales, hydrates, solvates, complexes and prodruges are inhibitors of cathepsin K and other cysteine protease inhibitors and are useful as therapeutic agents, for example in osteoporosis, Paget's disease gingival diseases such as gingivitis and periodontis, hypercalaemia of malignancy, metabolic bone disease, diseases involving matrix or cartilage degradation, in particular osteoarthitis and rheumatoid arthritis and neoplastic diseases.
Type:
Application
Filed:
July 15, 2003
Publication date:
May 11, 2006
Applicant:
Amura Therapeutics Limited
Inventors:
Martin Quibell, Peter Ray, John Watts